633 research outputs found
LHC Signature of Mirage Mediation
We study LHC phenomenology of mirage mediation scenario in which anomaly and
modulus contributions to soft SUSY breaking terms are comparable to each other.
A Monte Carlo study of mirage mediation, with model parameters , GeV, , and , is presented. It is
shown that masses of supersymmetric particles can be measured in a model
independent way, providing information on SUSY breaking sector. In particular,
the mass ratio of gluino to the lightest neutralino for the benchmark scenario
is determined to be 1.9 \lesssim m_{\tildeg}/m_{\tilde\chi_1^0} \lesssim 3.1,
well reproducing theoretical input value of which is quite distinctive from the predictions of other SUSY scenarios in which gaugino
masses are unified at the GUT scale. The model parameters of mirage mediation
can be also determined from various kinematic distributions
TeV scale partial mirage unification and neutralino dark matter
We study the TeV scale partial mirage unification scenario, where the gluino
and wino masses are degenerate around a TeV scale, but the bino mass is not
degenerate. This scenario has phenomenologically interesting aspects. First,
because of the degeneracy between the gluino and wino masses, this scenario
does not have the little hierarchy problem, that is, the higgisino mass is
around 150 GeV. The lightest superparticle is a mixture of the bino and
higgsino, and can lead to a right amount of thermal relic density as a dark
matter candidate
Singlet fermionic dark matter
We propose a renormalizable model of a fermionic dark matter by introducing a
gauge singlet Dirac fermion and a real singlet scalar. The bridges between the
singlet sector and the standard model sector are only the singlet scalar
interaction terms with the standard model Higgs field. The singlet fermion
couples to the standard model particles through the mixing between the standard
model Higgs and singlet scalar and is naturally a weakly interacting massive
particle (WIMP). The measured relic abundance can be explained by the singlet
fermionic dark matter as the WIMP within this model. Collider implication of
the singlet fermionic dark matter is also discussed. Predicted is the elastic
scattering cross section of the singlet fermion into target nuclei for a direct
detection of the dark matter. Search of the direct detection of the dark matter
provides severe constraints on the parameters of our model.Comment: 12 pages, 7 figure
Circulating endothelial cells demonstrate an attenuation of endothelial damage by minimizing the extracorporeal circulation
ObjectiveDetachment of endothelial cells may represent serious injury of the endothelium after cardiopulmonary bypass. We investigated whether the extent of endothelial injury is related to the type of cardiopulmonary bypass system used (conventional or minimized) and determined circulating endothelial cells as well as von Willebrand factor and soluble thrombomodulin.MethodsTwenty patients scheduled for elective coronary bypass grafting were randomly assigned to either the minimal extracorporeal circulation system or the standard cardiopulmonary bypass. Ten healthy volunteers served as controls. Circulating endothelial cells per milliliter of full blood were perioperatively determined by immunomagnetic cell separation technique. Endothelial plasma markers were measured by enzyme-linked immunosorbent assay.ResultsPreoperative circulating endothelial cell numbers did not differ between the experimental groups, but were significantly higher than in the healthy controls (18.6 ± 5.6 vs 7.2 ± 3.8, P < .001). At 6 hours, circulating endothelial cell numbers increased significantly compared with baseline in both experimental groups and peaked at 12 hours after cardiopulmonary bypass initiation, each time with significantly lower values in the minimal extracorporeal circulation group (6 hours: 44.0 ± 9.9 vs 29.6 ± 9.8, P = .007; 12 hours: 48.1 ± 6.8 vs 31.8 ± 7.1, P < .001). Likewise, von Willebrand factor and soluble thrombomodulin postoperatively increased in both groups with a tendency toward lower levels in the minimal extracorporeal circulation group. Although circulating endothelial cells gradually declined, continually with lower numbers in the minimal extracorporeal circulation group, the endothelial plasma markers remained elevated during observation time.ConclusionsCirculating endothelial cells represent a novel marker of the intrinsic endothelial damage caused by cardiopulmonary bypass. Its analysis facilitates the evaluation of cardiopulmonary bypass modifications as the minimal extracorporeal circulation system could be proven to be less injurious to endothelium and myocardium
Di-(2 ethylhexyl) phthalate and flutamide alter gene expression in the testis of immature male rats
We previously demonstrated that the androgenic and anti-androgenic effects of endocrine disruptors (EDs) alter reproductive function and exert distinct effects on developing male reproductive organs. To further investigate these effects, we used an immature rat model to examine the effects of di-(2 ethylhexyl) phthalate (DEHP) and flutamide (Flu) on the male reproductive system. Immature male SD rats were treated daily with DEHP and Flu on postnatal days (PNDs) 21 to 35, in a dose-dependent manner. As results, the weights of the testes, prostate, and seminal vesicle and anogenital distances (AGD) decreased significantly in response to high doses of DEHP or Flu. Testosterone (T) levels significantly decreased in all DEHP- treated groups, whereas luteinizing hormone (LH) plasma levels were not altered by any of the two treatments at PND 36. However, treatment with DEHP or Flu induced histopathological changes in the testes, wherein degeneration and disorders of Leydig cells, germ cells and dilatation of tubular lumen were observed in a dose-dependent manner. Conversely, hyperplasia and denseness of Leydig, Sertoli and germ cells were observed in rats given with high doses of Flu. The results by cDNA microarray analysis indicated that 1,272 genes were up-regulated by more than two-fold, and 1,969 genes were down-regulated in response to DEHP, Flu or both EDs. These genes were selected based on their markedly increased or decreased expression levels. These genes have been also classified on the basis of gene ontology (e.g., steroid hormone biosynthetic process, regulation of transcription, signal transduction, metabolic process, biosynthetic process...). Significant decreases in gene expression were observed in steroidogenic genes (i.e., Star, Cyp11a1 and Hsd3b). In addition, the expression of a common set of target genes, including CaBP1, Vav2, Plcd1, Lhx1 and Isoc1, was altered following exposure to EDs, suggesting that they may be marker genes to screen for the anti-androgenic or androgenic effects of EDs. Overall, our results demonstrated that exposure to DEHP, Flu or both EDs resulted in a alteration of gene expression in the testes of immature male rats. Furthermore, the toxicological effects of these EDs on the male reproductive system resulted from their anti-androgenic effects. Taken together, these results provide a new insight into the molecular mechanisms underlying the detrimental impacts of EDs, in regards to anti-androgenic effects in humans and wildlife
Measuring superparticle masses at hadron collider using the transverse mass kink
We present a detailed study of the collider observable applied for
pair-produced superparticles decaying to visible particles and a pair of
invisible lightest supersymmetric particles (LSPs). Analytic expressions of the
maximum of over all events () are derived. It is
noticed that if the decay product of each superparticle involves more than one
visible particles, being a function of the {\it trial} LSP
mass has a kink structure at true LSP mass, which can be
used to determine the mother superparticle mass and the LSP mass
simultaneously. To see how well can be constructed from
collider data, a Monte-Carlo analysis of the gluino is performed for
some superparticle spectra.Comment: Typos corrected. A few references added. Figures update
Neutralino Dark Matter in Mirage Mediation
We study the phenomenology of neutralino dark matter (DM) in mirage mediation
scenario of supersymmetry breaking which results from the moduli stabilization
in some string/brane models. Depending upon the model parameters, especially
the anomaly to modulus mediation ratio determined by the moduli stabilization
mechanism, the nature of the lightest supersymmetric particle (LSP) changes
from Bino-like neutralino to Higgsino-like one via Bino-Higgsino mixing region.
For the Bino-like LSP, the standard thermal production mechanism can give a
right amount of relic DM density through the stop/stau-neutralino
coannihilation or the pseudo-scalar Higgs resonance process. We also examine
the prospect of direct and indirect DM detection in various parameter regions
of mirage mediation. Neutralino DM in galactic halo might be detected by near
future direct detection experiments in the case of Bino-Higgsino mixed LSP. The
gamma ray flux from Galactic Center might be detectable also if the DM density
profile takes a cuspy shape.Comment: One reference adde
The mu problem and sneutrino inflation
We consider sneutrino inflation and post-inflation cosmology in the singlet
extension of the MSSM with approximate Peccei-Quinn(PQ) symmetry, assuming that
supersymmetry breaking is mediated by gauge interaction. The PQ symmetry is
broken by the intermediate-scale VEVs of two flaton fields, which are
determined by the interplay between radiative flaton soft masses and higher
order terms. Then, from the flaton VEVs, we obtain the correct mu term and the
right-handed(RH) neutrino masses for see-saw mechanism. We show that the RH
sneutrino with non-minimal gravity coupling drives inflation, thanks to the
same flaton coupling giving rise to the RH neutrino mass. After inflation,
extra vector-like states, that are responsible for the radiative breaking of
the PQ symmetry, results in thermal inflation with the flaton field, solving
the gravitino problem caused by high reheating temperature. Our model predicts
the spectral index to be n_s\simeq 0.96 due to the additional efoldings from
thermal inflation. We show that a right dark matter abundance comes from the
gravitino of 100 keV mass and a successful baryogenesis is possible via
Affleck-Dine leptogenesis.Comment: 27 pages, no figures, To appear in JHE
Pharmacokinetic study of meropenem in healthy beagle dogs receiving intermittent hemodialysis
Meropenem, a second carbapenem antimicrobial agent with a broad spectrum of activity, is used to treat sepsis and resistant-bacterial infections in veterinary medicine. The objective of this study was to identify the pharmacokinetics of meropenem in dogs receiving intermittent hemodialysis (IHD) and to determine the proper dosing in renal failure patients receiving IHD. Five healthy beagle dogs were given a single i.v. dose of 24 mg/kg of meropenem and received IHD. The blood flow rate, dialysate flow, and ultrafiltration rate were maintained at 40 mL/min, 300 mL/min, and 40 mL/h, respectively. Blood samples were collected for 24 h from the jugular vein and from the extracorporeal arterial and venous line. Urine samples and dialysate were also collected. The concentrations of meropenem were assayed using HPLC/MS/MS determination. The peak plasma concentration was 116 +/- 37 mu g/mL at 15 min. The systemic clearance was 347 +/- 117 mL/h/kg, and the steady-state volume of distribution was 223 +/- 67 mL/kg. Dialysis clearance was 71.1 +/- 34.3 mL/h/kg, and the extraction ratio by hemodialysis was 0.455 +/- 0.150. The half-life (T-1/2) in dogs with IHD decreased compared with those without IHD, and the reduction in T1/2 was greater in renal failure patients than in normal patients. Sixty-nine percent and 21% of the administered drug were recovered by urine and dialysate in the unchanged form, respectively. In conclusion, additional dosing of 24 mg/kg of meropenem after dialysis could be necessary according to the residual renal function of the patient based on the simulated data.OAIID:RECH_ACHV_DSTSH_NO:T201621129RECH_ACHV_FG:RR00200001ADJUST_YN:EMP_ID:A003050CITE_RATE:1.279FILENAME:Byun_et_al-2016-Journal_of_Veterinary_Pharmacology_and_Therapeutics.pdfDEPT_NM:수의학과EMAIL:[email protected]_YN:YFILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/eb2b2d93-6cb2-4420-a374-90eb43215957/linkCONFIRM:
Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice
Abstract
Ketamine, a non-competitive antagonist of the N-methyl-d-aspartate receptor (NMDAR), generates a rapidly-acting antidepressant effect. It exerts psychomimetic effects, yet demands a further investigation of its mechanism. Previous research showed that ketamine did no longer promote hyperlocomotion in GluN2D knockout (KO) mice, which is a subunit of NMDAR. In the present study, we tested whether GluN2D-containing NMDARs participate in the physiological changes in the medial prefrontal cortex (mPFC) triggered by ketamine. Sub-anesthetic dose of ketamine (25mg/kg) elevated the frequency of spontaneous excitatory postsynaptic currents (sEPSC) in wild-type (WT) mice, but not in GluN2D KO mice, 1h after the injection. The amplitude of sEPSC and paired-pulse ratio (PPR) were unaltered by ketamine in both WT and GluN2D KO mice. These findings suggest that GluN2D-containing NMDARs might play a role in the ketamine-mediated changes in glutamatergic neurons in mPFC and, presumably, in ketamine-induced hyperlocomotion
- …