Decaffeinated Green Coffee Bean Extract Attenuates Diet-Induced Obesity and Insulin Resistance in Mice

This study investigated whether decaffeinated green coffee bean extract prevents obesity and improves insulin resistance and elucidated its mechanism of action. Male C57BL/6N mice (N=48) were divided into six dietary groups: chow diet, HFD, HFD-supplemented with 0.1%, 0.3%, and 0.9% decaffeinated green coffee bean extract, and 0.15% 5-caffeoylquinic acid. Based on the reduction in HFD-induced body weight gain and increments in plasma lipids, glucose, and insulin levels, the minimum effective dose of green coffee bean extract appears to be 0.3%. Green coffee bean extract resulted in downregulation of genes involved in WNT10b- and galanin-mediated adipogenesis and TLR4-mediated proinflammatory pathway and stimulation of GLUT4 translocation to the plasma membrane in white adipose tissue. Taken together, decaffeinated green coffee bean extract appeared to reverse HFD-induced fat accumulation and insulin resistance by downregulating the genes involved in adipogenesis and inflammation in visceral adipose tissue

Numerical model of journal bearing lubrication considering a bending stiffness effect

An analysis for operating characteristics of journal bearing lubrication system is performed based on the numerical model. Dynamic bearing lubrication characteristics such as oil film pressure and thickness distribution can be analyzed through a numerical model with an integration of elastohydrodynamics and multi-flexible-body dynamics (MFBD). In particular, the oil film thickness variation by elastic deformation is considered in the elastohydrodynamic analysis by applying the bending stiffness effect of journal. And the oil film thickness variation by the bending stiffness effect is applied to the fluid governing equations to calculate the oil film pressure in the elastohydrodynamic lubrication region. A series of process proposed in this study is available for the analysis of realistic elastohydrodynamic lubrication phenomenon. Also, a numerical example for the journal bearing lubrication system is demonstrated and compared with the experimental results. The numerical results considering the bending stiffness effect show a good agreement with the experimental results