Neuromuscular Electrical Stimulation of Abdominal Muscles to Improve Standing Balance

Background: Neuromuscular electrical stimulation (NMES) is used for muscle strengthening. While voluntary muscle contraction follows Henneman et al.’s size principle, the NMES-in-duced muscle training disrespects the neurophysiology, which may lead to unwanted changes (i.e., declined balance ability).Objects: We examined how the balance was affected by abdominal muscle training with the NMES.Methods: Fifteen young adults (10 males and 5 females) aged between 21 and 30 received abdominal muscle strengthening with NMES for 23 minutes. Before and after the training, participants’ balance was measured through one leg standing on a force plate with eyes open or closed. Outcome variables included mean distance (MDIST), root mean square dis-tance (RDIST), total excursion (TOTEX), mean velocity (MVELO), and 95% confidence circle area (AREA) of center of pressure data. Two-way repeated measures analysis of variance was used to test if these outcome variables were associated with time (pre and post) and vision.Results: All outcome variables were not associated with time (p > 0.05). However, all out-come variables were associated with vision (p = 0.0001), and MVELO and TOTEX were 52.4% (45.5 mm/s versus 95.6 mm/s) and 52.4% (364.1 mm versus 764.5 mm) smaller, respectively, in eyes open than eyes closed (F = 55.8, p = 0.0005; F = 55.8, p = 0.0005). Furthermore, there was no interaction between time and vision (F = 0.024, p = 0.877).Conclusion: Despite the different neurophysiology of muscle contraction, abdominal muscle strengthening with NMES did not affect balance

River Stage Modeling by Combining Maximal Overlap Discrete Wavelet Transform, Support Vector Machines and Genetic Algorithm

This paper proposes a river stage modeling approach combining maximal overlap discrete wavelet transform (MODWT), support vector machines (SVMs) and genetic algorithm (GA). The MODWT decomposes original river stage time series into sub-time series (detail and approximation components). The SVM computes daily river stage values using the decomposed sub-time series. The GA searches for the optimal hyperparameters of SVM. The performance of MODWT–SVM models is evaluated using efficiency and effectiveness indices; and compared with that of a single model (multilayer perceptron (MLP) and SVM), discrete wavelet transform (DWT)-based models (DWT–MLP and DWT–SVM) and MODWT–MLP models. The conjunction of MODWT, SVM and GA improves the performance of the SVM model and outperforms the single models. The MODWT–based models using the SVM model enhance model performance and accuracy compared to those of using MLP model. Also, hybrid models coupling MODWT, SVM and GA improve model performance and accuracy in daily river stage modeling as compared with those combined with DWT. The MODWT–SVM model using the Coiflet 12 (c12) mother wavelet, MODWT–SVM-c12, produces the best efficiency and effectiveness among all models. Therefore, the conjunction of MODWT, SVM and GA can be an efficient and effective approach for modeling daily river stages

Breakup Mechanism of a Jet in the L-Shape Crossflow of a Gas Turbine Combustor

Experimental investigations are conducted to determine the mechanism and characteristics of a jet in an L-shape crossflow simulating the radial swirl injector of a lean premixed-prevaporized (LPP) combustor. To simplify the radial flow of the actual injector while ignoring the centrifugal effect, the L-shaped 2D-channel is used for the crossflow, and water is used as a fuel simulant. The jet breakup is captured using a high-speed camera, and the density gradient magnitude is post-processed to clarify the spray. The Sauter mean diameter (SMD) of the spray is measured via a laser diffraction method with a helium–neon laser optical system (HELOS). The characteristics of the jet in the L-shape crossflow are compared with the characteristics of the jet in a typical crossflow through the flat channel. The results for different outlet heights of the L-shape channel (H/d0) and different injector positions (L/d0) are presented. A dimensionless number (τ) consisting of a time ratio is introduced to describe the jet characteristics. In a previous work, the spraying tendency was demonstrated for different injector positions. In addition, the effect of the recirculation area on H/d0 was empirically shown. H/d0 determines the size of the recirculation area, and the range of τ determines the jet breakup mechanism inside the L-shape channel. The results of this study present the breakup mechanism of the jet in the L-shape channel flow, which simulates a jet in a radial swirler injector for gas turbine engines. It is expected that these results can be used to assist in designing gas turbine engines with more combustion efficiency

Breakup Mechanism of a Jet in the L-Shape Crossflow of a Gas Turbine Combustor

Experimental investigations are conducted to determine the mechanism and characteristics of a jet in an L-shape crossflow simulating the radial swirl injector of a lean premixed-prevaporized (LPP) combustor. To simplify the radial flow of the actual injector while ignoring the centrifugal effect, the L-shaped 2D-channel is used for the crossflow, and water is used as a fuel simulant. The jet breakup is captured using a high-speed camera, and the density gradient magnitude is post-processed to clarify the spray. The Sauter mean diameter (SMD) of the spray is measured via a laser diffraction method with a helium–neon laser optical system (HELOS). The characteristics of the jet in the L-shape crossflow are compared with the characteristics of the jet in a typical crossflow through the flat channel. The results for different outlet heights of the L-shape channel (H/d0) and different injector positions (L/d0) are presented. A dimensionless number (τ) consisting of a time ratio is introduced to describe the jet characteristics. In a previous work, the spraying tendency was demonstrated for different injector positions. In addition, the effect of the recirculation area on H/d0 was empirically shown. H/d0 determines the size of the recirculation area, and the range of τ determines the jet breakup mechanism inside the L-shape channel. The results of this study present the breakup mechanism of the jet in the L-shape channel flow, which simulates a jet in a radial swirler injector for gas turbine engines. It is expected that these results can be used to assist in designing gas turbine engines with more combustion efficiency

Optimal Implementation Parameters of a Nonlinear Electrical Impedance Tomography Method Using the Complete Electrode Model

This study discusses a nonlinear electrical impedance tomography (EIT) technique under different analysis conditions to propose its optimal implementation parameters. The forward problem for calculating electric potential is defined by the complete electrode model. The inverse problem for reconstructing the target electrical conductivity profile is presented based on a partial-differential-equation-constrained optimization approach. The electrical conductivity profile is iteratively updated by solving the Karush–Kuhn–Tucker optimality conditions and using the conjugate gradient method with an inexact line search. Various analysis conditions such as regularization scheme, number of electrodes, current input patterns, and electrode arrangement were set differently, and the corresponding results were compared. It was found from this study that the proposed EIT method yielded appropriate inversion results with various parameter settings, and the optimal implementation parameters of the EIT method are presented. This study is expected to expand the utility and applicability of EIT for the non-destructive evaluation of structures

Hardware Performance Monitoring Methodology at Near-Threshold Computing and Advanced Technology Nodes: From Design to Postsilicon

Near-threshold computing is essential for energy-efficient operation of VLSI systems, but wide performance variation and nonlinearity to process variations block the proliferation. To cope with this, in this article, we propose a holistic hardware performance monitoring methodology for accurate timing prediction in a near-threshold voltage regime. Precisely, 1) we formulate the problem of finding an efficient configuration of monitoring circuits into an instance of optimal experiment design problem and 2) propose a new timing prediction flow, consisting of statistical estimation of FEOL and BEOL process variations and a neural network-based timing inference model. For accurate control of timing margin and overcoming simulation-silicon discrepancies, 3) we introduce uncertainty learning in the prediction model construction and calibrate it through transfer learning. Furthermore, 4) we avoid time-consuming SPICE simulations in our methodology by employing efficient but accurate surrogate models. Through simulations using a 28-nm industry PDK and DK characterized at 0.6-V operation, it is shown that our methodology is highly effective, reducing the average prediction pessimism of maximum delay by 77.9% over conventional signoff results while respecting target prediction yield. Besides, for test chips fabricated using a 10-nm process, we demonstrated that our holistic approach from design to postsilicon phase in conjunction with adaptive voltage scaling reduces dynamic power consumption by 28.2 %-28.8% on average, in comparison with typical supply voltage operation.N

Translocation of the conus medullaris during dynamic lumbosacral magnetic resonance imaging in dogs

OBJECTIVE To investigate the change in the lumbosacral angle (Delta LSA) and conus medullaris (CM) displacement in healthy dogs undergoing dynamic MRI with changes in the posture of their pelvic limbs from neutral posture to flexion or extension posture and to evaluate for potential correlation between Delta LSA and CM displacement. ANIMALS 9 healthy adult Beagles. PROCEDURES Dogs underwent dynamic MRI with their pelvic limbs positioned in neutral, flexion, and extension postures. From T2-weighted sagittal midline plane MRI images, 2 observers measured the lumbosacral angle and CM location in duplicate for each posture for each dog. Intra- and interobserver agreement was assessed, and the Spearman rank correlation coefficient (rho) was used to assess for potential correlation between Delta LSA and CM displacement for changes in pelvic limb posture from neutral to flexion or extension. RESULTS Overall, the mean Delta LSA and CM displacement for changes in posture were 23 degrees and 9.09 mm (caudal displacement) for the change from neutral to flexion posture, 8.4 degrees and -2.5 mm (cranial displacement) for the change from neutral to extension posture, and 32.2 degrees and 11.64 mm (caudal displacement) for the change from extension to flexion posture. The Delta LSA strongly correlated (p = 0.705: 95% CI, 0.434 to 0.859) with displacement of the CM. CONCLUSIONS AND CLINICAL RELEVANCE The use of dynamic MR1, compared with conventional MRI, will better help to characterize clinically normal and abnormal features of the lumbosacral region of the vertebral column and associated spinal cord during postural changes. Further, when limited translocation of the CM is evident on dynamic MRI, veterinarians should suspect underlying lumbosacral pathophysiologic processes or anatomic abnormalities.Y

ADAM10 Is Involved in Cell Junction Assembly in Early Porcine Embryo Development.

ADAM10 (A Disintegrin and Metalloprotease domain-containing protein 10) is a cell surface protein with a unique structure possessing both potential adhesion and protease domains. However, the role of ADAM10 in preimplantation stage embryos is not clear. In this study, we examined the expression patterns and functional roles of ADAM10 in porcine parthenotes during preimplantation development. The transcription level of ADAM10 dramatically increased from the morula stage onward. Immunostaining revealed that ADAM10 was present in both the nucleus and cytoplasm in early cleavage stage embryos, and localized to the apical region of the outer cells in morula and blastocyst embryos. Knockdown (KD) of ADAM10 using double strand RNA did not alter preimplantation embryo development until morula stage, but resulted in significantly reduced development to blastocyst stage. Moreover, the KD blastocyst showed a decrease in gene expression of adherens and tight junction (AJ/TJ), and an increase in trophectoderm TJ permeability by disrupting TJ assembly. Treatment with an ADAM10 specific chemical inhibitor, GI254023X, at the morula stage also inhibited blastocyst development and led to disruption of TJ assembly. An in situ proximity ligation assay demonstrated direct interaction of ADAM10 with coxsackie virus and adenovirus receptor (CXADR), supporting the involvement of ADAM10 in TJ assembly. In conclusion, our findings strongly suggest that ADADM10 is important for blastocyst formation rather than compaction, particularly for TJ assembly and stabilization in preimplantation porcine parthenogenetic development

Evaluation of a dual-purpose contrast medium for radiography and ultrasonography of the small intestine in dogs

OBJECTIVE To evaluate a contrast medium that could be used for radiographic and ultrasonographic assessment of the small intestine in dogs. ANIMALS 8 healthy adult Beagles. PROCEDURES Carboxymethylcellulose (CMC; 0.5% solution) was combined with iohexol (300 mg of iodine/mL) to yield modified contrast medium (MCM). Dogs were orally administered the first of 3 MC Ms (10 mL/kg [9.5 mL of CMC/kg plus 0.5 mL of iohexol/kg]). Radiographic and ultrasonographic assessment of the small intestine followed 10 minutes after administration and every 10 minutes thereafter, until MCM was seen within the ascending colon. Minimally, 1 week elapsed between dosing of subsequent MCMs (10 mL/kg [9 mL of CMC/kg plus I mL of iohexol/kg and 8.5 mL of CMC/kg plus 1.5 mL of iohexol/kg]) and repeated radiography and ultrasonography. RESULTS Radiographic contrast enhancement of the small intestine was best with MCM that combined 8.5 mL of CMC/kg and 1.5 mL of iohexol/kg. Mean small intestinal transit time for all MCMs was 86 minutes. All MCMs did not interfere with ultrasonographic assessment of the small intestine and may have improved visualization of the far-field small intestinal walls. CONCLUSIONS AND CLINICAL RELEVANCE An MCM that combined 8.5 mL of 0.5% CMC/kg and 1.5 mL of iohexol/kg could be an alternative to barium or iohexol alone for contrast small intestinal radiography in dogs, especially when abdominal ultrasonography is to follow contrast radiography.N