Voicing Back: The Poetics and Politics of Ping Chong's Ethno-Historiographic Fables

In spite of Ping Chong¡¯s reputation in the American theatre scene, little has been done to explore his artistic works from a fully theorized perspective. In this dissertation, I propose a category of ¡°cultural narrative texts¡± to investigate cultural and historical themes of ¡°culture and the other¡± in Chong¡¯s fascinating ethno-historiographic fables. The poetics and politics of Chong¡¯s narrative texts are the subject of this dissertation. The frames of myth and narratology in their constructive aspects (how the mythic narratives are expressed) provide the poetics part. I adopt the literary approaches of Northrop Frye and Kenneth Burke for their intense studies on image (narrative unit), rhetoric (narrative signification), and emplotment (narrative sequence). In a connective linkage from poetics, the politics part engages the cultural and historical thematics through which I read what is expressed in Chong¡¯s (counter-) myths on people, cultures, and histories. For this complex thematic part, I construe a theoretical bricolage of a broad range of disciplines and methodologies, from psychoanalysis, cognitive science, anthropology, historiography, sociology, to poststructuralism, postcolonialism, and feminism.This dissertation deals with Chong¡¯s ethno-historiographic fables throughout his theatrical career over three decades, examining how his deconstructive myth-making wrestles with the problematic notion of ¡°the other¡± in both local (national) and global aspects. Borrowing Julia Kristeva¡¯s socially informed psychoanalysis, I approach Chong¡¯s concept of ¡°the other¡± as ¡°social abject¡± inhibiting at the margins. I argue that through Chong¡¯s (counter-) myth-making which destabilizes the authority of hegemonic narratives of the incompatible split between the self and the other, multiple voices of the marginalized return, and the monologue of the hegemonic culture is interrupted. In this dissertation, I demonstrate how the performance of Chong¡¯s (counter-) narratives, what I call ¡°voicing back,¡± resist the silence, enabling the marginalized abject to become the subjects of their own desires and histories. This ¡°voicing back¡± in its shared political languages of respect, equality, and justice (toward the others) prepares for the performance of a democracy which is based on the complete modes of speech acts, speaking and listening

Combined impact of elevated arterial stiffness and left ventricular filling pressure on outcomes after off-pump coronary artery bypass grafting

Abstract Background Brachial-ankle pulse wave velocity (baPWV) and early diastolic transmitral flow velocity to mitral annular tissue velocity (E/e′)—which are markers of arterial stiffness and left ventricular (LV) filling pressure, respectively—have been associated with morbidity and mortality. We investigated their combined impact on postoperative complications and long-term survival of patients undergoing off-pump coronary artery bypass grafting (OPCAB). Methods A cohort of 164 patients were divided into four groups: baPWV ≤ 19m/s and E/e′ ≤ 15 (reference), baPWV > 19m/s and E/e′ ≤ 15 (high-PWV-only), baPWV ≤ 19m/s and E/e′ > 15 (high-E/e′-only), and baPWV > 19m/s and E/e′ > 15 (high-PWV-and-E/e′). After inverse probability treatment weighting adjustment, each group was compared with the reference group to analyze the odds ratios of postoperative complications and the Kaplan–Meier survival curves, and to identify the group representing an independent prognostic predictor. Results The median age and follow-up duration were 69years and 57.2months, respectively. Both postoperative acute kidney injury (POAKI) and atrial fibrillation (POAF) were higher in the high-PWV-and-E/e′ group (adjusted odds ratio (OR) = 89.5; 95% confidence interval (CI), 8.5–942.3; p < 0.001 and OR = 12.5; CI, 2.5–63.8; p = 0.002, respectively). Compared to the reference group, only the high-PWV-and-E/e′ group showed significantly lower survival rate (91.0%; CI, 82.8–100% vs. 44.8%; CI, 21.2–94.6%) and a higher hazard for all-cause mortality after adjustment for covariates (hazard ratio = 6.1; p = 0.002). Conclusion Concurrent elevation in PWV and E/e′ may independently affect not only the rates of POAKI and POAF but also long-term survival after OPCAB

Zero-frequency Bragg gap by spin-harnessed metamaterial

The Bragg gap that stops wave propagation may not be formed from zero or a very low frequency unless the periodicity of a periodic system is unrealistically large. Accordingly, the Bragg gap has been considered to be inappropriate for low frequency applications despite its broad bandwidth. Here, we report a new mechanism that allows formation of the Bragg gap starting from a nearly zero frequency. The mechanism is based on the finding that if additional spin motion is coupled with the longitudinal motion of a mass of a diatomic mechanical periodic system, the Bragg gap starting from a nearly zero frequency can be formed. The theoretical analysis shows that the effective mass and stiffness at the band gap frequencies are all positive, confirming that the formed stop band is a Bragg gap. The periodic system is realized by a spin-harnessed metamaterial which incorporates unique linkage mechanisms. The numerical and experimental validation confirmed the formation of the low-frequency Bragg gap. The zero-frequency Bragg gap is expected to open a new way to control hard-to-shield low-frequency vibration and noise

IRT5 Probiotics Changes Immune Modulatory Protein Expression in the Extraorbital Lacrimal Glands of an Autoimmune Dry Eye Mouse Model

PURPOSE. While the association between the gut microbiome and the immune system has been studied in autoimmune disorders, little is known about ocular disease. Previously we reported that IRT5, a mixture of five probiotic strains, could suppress autoimmune dry eye. In this study, we investigated the mechanism by which IRT5 performs its immunomodulatory function in a mouse model of autoimmune dry eye. METHODS. NOD.B10.H2b mice were used as an autoimmune dry eye model. Either IRT5 or PBS was gavaged orally for 3 weeks, with or without 5 days of antibiotic pretreatment. The effects on clinical features, extraorbital lacrimal gland and spleen proteins, and fecal microbiota were analyzed. RESULTS. The ocular staining score was lower, and tear secretion was higher, in the IRT5-treated groups than in the PBS-treated groups. After IRT5 treatment, the downregulated lacrimal gland proteins were enriched in the biological processes of defense response and immune system process. The relative abundances of 33 operational taxonomic units were higher, and 53 were lower, in the feces of the IRT5-treated groups than in those of the PBS-treated groups. IRT5 administration without antibiotic pretreatment also showed immunomodulatory functions with increases in the Lactobacillus helveticus group and Lactobacillus hamsteri. Additional proteomic assays revealed a decrease of proteins related to antigen-presenting processes in the CD11b(+) and CD11c(+) cells of spleen in the IRT5-treated groups. CONCLUSIONS. Changes in the gut microbiome after IRT5 treatment improved clinical manifestations in the autoimmune dry eye model via the downregulation of antigen-presenting processes in immune networks.11Ysciescopu

Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation

The chronic low-grade inflammation in adipose tissue plays a causal role in obesity-induced insulin resistance and its associated pathophysiological consequences. In this study, we investigated the effects of extracts of Broussonetia papyrifera root bark (PRE) and its bioactive components on inflammation and insulin sensitivity. PRE inhibited TNF-alpha-induced NF-kappa B transcriptional activity in the NF-kappa B luciferase assay and pro-inflammatory genes&apos; expression by blocking phosphorylation of I kappa B and NF-kappa B in 3T3-L1 adipocytes, which were mediated by activating AMPK. Ten-week-high fat diet (HFD)-fed C57BL6 male mice treated with PRE had improved glucose intolerance and decreased inflammation in adipose tissue, as indicated by reductions in NF-kappa B phosphorylation and pro-inflammatory genes&apos; expression. Furthermore, PRE activated AMP-activated protein kinase (AMPK) and reduced lipogenic genes&apos; expression in both adipose tissue and liver. Finally, we identified broussoflavonol B (BF) and kazinol J (KJ) as bioactive constituents to suppress pro-inflammatory responses via activating AMPK in 3T3-L1 adipocytes. Taken together, these results indicate the therapeutic potential of PRE, especially BF or KJ, in metabolic diseases such as obesity and type 2 diabetes