Prompt Injection: Parameterization of Fixed Inputs

Recent works have shown that attaching prompts to the input is effective at conditioning Language Models (LM) to perform specific tasks. However, prompts are always included in the input text during inference, thus incurring substantial computational and memory overhead. Also, there is currently no straightforward method of utilizing prompts that are longer than the maximum input length of the LMs without incurring additional costs during inference. We propose Prompt Injection (PI), a novel formulation of injecting the prompt into the parameters of an LM to be an efficient alternative to attaching fixed prompts to the input. We show that in scenarios with long fixed prompts, PI can be up to 280 times more efficient in terms of total FLOPs than previous approaches. We further explore methodologies for PI and show promising results in persona-dependent conversation, semantic parsing, and zero-shot learning with task instructions. Through these explorations, we show that PI can be a promising direction for conditioning language models, especially in scenarios with long and fixed prompts.Comment: PING results in Table 2 updated (bug fixed

Relationship between core self-evaluation and innovative work behavior: mediating effect of affective organizational commitment and moderating effect of organizational learning capacity

Focusing on employees, this study examined the respective mediating and moderating effects of affective organizational commitment and organizational learning capacity in the relationship between core self-evaluation and innovation work behavior. We collected data via an online survey from 330 office workers at midsize and large companies in a metropolitan area of South Korea. The results of analyzing the data using PROCESS macro were as follows: (1) core self-evaluation was positively related to innovative work behavior; (2) the relationship was mediated by affective organizational commitment; (3) the relationship was buffered by organizational learning capacity, such that a higher level of organizational learning capacity diminished the impact of core self-evaluation on innovative wok behavior; and (4) the conditional effect of core self-evaluation on innovative work behavior existed only in the group of a low level of organizational learning capacity. Based on these findings, we suggested implications for theory building, research, and practice

Outcomes after the surgery for acquired nonaccommodative esotropia

Abstract Background To analyze the surgical outcomes for patients diagnosed with acquired nonaccommodative esotropia (ANAET). Methods In this retrospective study, the medical records of 35 patients who had undergone the surgery for ANAET with a postoperative follow-up period of 6 months or more were reviewed. The main outcome measures were postoperative esodeviation angle, final success rate, and factors affecting surgical outcome. Surgical success was considered to be an alignment within 8 prism diopters (PD) at distance and near. Results The preoperative mean esodeviation angles were 37.3 ± 13.7 PD at distance and 38.6 ± 16.6 PD at near. The postoperative mean esodeviation angles at distance were as follows: 4.2 PD at day 1, 4.0 PD at month 1, 3.9 PD at month 3, 4.9 PD at month 6, 4.7 PD at year 1, and 4.8 PD at final follow-up. There was no statistically significant difference in angle of esodeviation between the initial postoperative period (day 1 to month 6) and the final follow-up day (p > 0.05). The surgical success rate at final follow-up was 65.7% (23/35). Among the 12 patients for whom the surgery failed, 9 (24.3%) showed esotropia and 3 (8.1%) exotropia of more than 8 PD. Six patients (16.2%) underwent reoperation (4 for esotropia and 2 for exotropia). There was no factor influencing surgical outcome (p > 0.05). Conclusions The surgical outcome in patients with ANAET was relatively favorable: the final success rate was 65.7% and the reoperation rate was 17.1%

Alteration of metabolic profiles in Lemna paucicostata culture and enhanced production of GABA and ferulic acid by ethephon treatment.

Lemna species have been used in the food, feed, and pharmaceutical industries, as they are inexpensive sources of proteins, starches, and fatty acids. In this study, we treated L. paucicostata with different concentrations (0.05, 0.1, 0.2, 0.5, or 1 mM) of ethephon. The total dry weight decreased in all ethephon-treated groups compared to the control group. We also investigated the alteration of metabolic profiles induced by ethephon treatment by using gas chromatography-mass spectrometry. This analysis identified 48 metabolites, and the relative levels of most of alcohols, amino acids, fatty acids, and phenols increased by the ethephon treatment, whereas levels of organic acids and sugars decreased. Among these, the highest production of γ-aminobutyric acid (GABA, 5.041 ± 1.373 mg/L) and ferulic acid (0.640 ± 0.071 mg/L) was observed in the 0.5 mM and the 0.2 mM ethephon treatment groups, respectively. These results could be useful for large-scale culture of L. paucicostata with enhanced GABA and ferulic acid content for utilization in the food, feed, cosmetic, and pharmaceutical industries

Optimization Framework for Temporal Interference Current Tibial Nerve Stimulation in Tibial Nerves Based on In-Silico Studies

Compared to the existing noninvasive methods, temporal interference (TI) current stimulation is an emerging noninvasive neuromodulation technique that can improve the ability to focus an electrical field on a target nerve. Induced TI field distribution depends on the anatomical structure of individual neurons, and thus the electrode and current optimization to enhance the field focus must reflect these factors. The current study presents a TI field optimization framework for focusing the stimulation energy on the target tibial nerve through extensive electrical simulations, factoring in individual anatomical differences. We conducted large-scale in-silico experiments using realistic models based on magnetic resonance images of human subjects to evaluate the effectiveness of the proposed methods for tibial nerve stimulation considering overactive bladder (OAB) treatment. The electrode position and current intensity were optimized for each subject using an automated algorithm, and the field-focusing performance was evaluated based on the maximum intensity of the electric fields induced at the target nerve compared with the electric fields in the neighboring tissues. Using the proposed optimization framework, the focusing ability increased by 12% when optimizing the electrode position. When optimizing both the electrode position and current, this capability increased by 11% relative to electrode position optimization alone. These results suggest the significance of optimizing the electrode position and current intensity for focusing TI fields at the target nerve. Our electrical simulation-based TI optimization framework can be extended to enable personalized peripheral nerve stimulation therapy to modulate peripheral nerves.11Ysciescopu

GSK-3α Inhibition in Drug-Resistant CML Cells Promotes Susceptibility to NK Cell-Mediated Lysis in an NKG2D- and NKp30-Dependent Manner

Natural killer (NK) cells are innate cytotoxic lymphocytes that provide early protection against cancer. NK cell cytotoxicity against cancer cells is triggered by multiple activating receptors that recognize specific ligands expressed on target cells. We previously demonstrated that glycogen synthase kinase (GSK)-3β, but not GSK-3α, is a negative regulator of NK cell functions via diverse activating receptors, including NKG2D and NKp30. However, the role of GSK-3 isoforms in the regulation of specific ligands on target cells is poorly understood, which remains a challenge limiting GSK-3 targeting for NK cell-based therapy. Here, we demonstrate that GSK-3α rather than GSK-3β is the primary isoform restraining the expression of NKG2D ligands, particularly ULBP2/5/6, on tumor cells, thereby regulating their susceptibility to NK cells. GSK-3α also regulated the expression of the NKp30 ligand B7-H6, but not the DNAM-1 ligands PVR or nectin-2. This regulation occurred independently of BCR-ABL1 mutation that confers tyrosine kinase inhibitor (TKI) resistance. Mechanistically, an increase in PI3K/Akt signaling in concert with c-Myc was required for ligand upregulation in response to GSK-3α inhibition. Importantly, GSK-3α inhibition improved cancer surveillance by human NK cells in vivo. Collectively, our results highlight the distinct role of GSK-3 isoforms in the regulation of NK cell reactivity against target cells and suggest that GSK-3α modulation could be used to enhance tumor cell susceptibility to NK cells in an NKG2D- and NKp30-dependent manner

Enrichment of infection-associated bacteria in the low biomass brain bacteriota of Alzheimer's disease patients.

Alzheimer's disease (AD) is a neurodegenerative disease accompanied by neuroimmune inflammation in the frontal cortex and hippocampus. Recently, the presence of bacteria in AD-affected brains has been documented, prompting speculation about their potential role in AD-associated neuroinflammation. However, the characterization of bacteriota in human brains affected by AD remains inconclusive. This study aimed to investigate potential associations between specific bacteria and AD pathology by examining brain tissues from AD-associated neurodegenerative regions (frontal cortex and hippocampus) and the non-AD-associated hypothalamus. Employing 16S rRNA gene sequencing, 30 postmortem brain tissue samples from four individuals with normal brain histology (N) and four AD patients were analyzed, along with three blank controls. A remarkably low biomass characterized the brain bacteriota, with their overall structures delineated primarily by brain regions rather than the presence of AD. While most analyzed parameters exhibited no significant distinction in the brain bacteriota between the N and AD groups, the unique detection of Cloacibacterium normanense in the AD-associated neurodegenerative regions stood out. Additionally, infection-associated bacteria, as opposed to periodontal pathogens, were notably enriched in AD brains. This study's findings provide valuable insights into potential link between bacterial infection and neuroinflammation in AD

Achieving outstanding Li+-ORR and -OER activities via edge- and corner-embedded bimetallic nanocubes for rechargeable Li-O-2 batteries

The shape of catalysts has been regarded as a crucial physical factor to determine its catalytic activity in various applications. However, very little is known about the catalyst shape dependent activities for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) in the cathode of Li-O-2 battery. Hence, we synthesized Pt3Co nanocube (NC) for the comparison with Pt3Co nanoparticle (NP) by regulating the ratio of reducer (hexadecanediol; HDD) amount. Consequently, we could report on very high capacity (10,000 mA h g(carbon)(-1)), superb rate capability (3500 mA h g(caribon)(-1) at 2000 mA g(caribon)(-1)) and high reversibility of Lithium-O-2 batteries using Pt3Co NC catalysts. Particularly, the Pt3Co NCs catalyst exhibited a low OER potential of 3.1 V, providing the highest round trip efficiency of similar to 86.5% at a current density of 200 mA g(caribon)(-1) which is much superior to NPs catalyst. (C) 2015 Elsevier Ltd. All rights reserved.

Application of Bottom Ash as Filter Media for Construction Site Runoff Control

The potential application of bottom ash (BA) for construction site runoff control as an alternative filter media with high removal efficiency of total suspended solids (TSS) and longer operation period were evaluated. Both lab-scale single-layer and pilot-scale multi-layer filtration experiments were performed using BA filter media with different particle sizes and various volumetric flow rates. Due to the mesoporous, irregular, and spherical shape of gravel-size BA filter media used in this study, relatively low surface area, negligible pore volume, and greater pore size were observed. Both TSS removal efficiencies and clogging of BA filter media were a complex function of particle size of BA filter media and loading rate of TSS. Incoming TSS particles did not significantly penetrate beyond 46-cm BA filter media depth, accumulating on the upper layers and gradually forming a clogging layer to critical thickness, and finally the clogging filtration mechanism dominated the overall removal efficiency of TSS. Accumulation of TSS on BA filter media can be explained by the lumped sigmoidal empirical model, and an exponential decline in accumulation of TSS with depth results in minimal accumulation beneath the clogging layer. As practical implications, BA filter media depth of less than 46 cm is recommended with dual- or multi-media filters using mixtures of gravel-size BA and silt-size fine media, and a combination of detention basins can reduce frequent periodic de-clogging operation and management

Developing a Computational Model of Renal Nerves and Surgical System for Laparoscopic Renal Denervation

The sympathetic nervous system was known to play an important role in resistant hypertension. Surgical sympathectomy for renal sympathetic nerve removal were performed since the 1930s. Although effective, it had many serious side effects and complications due to non-selective property. Recently, catheter based RDN system using radiofrequency (RF) ablation was developed and considered promising, however, it failed in sham controlled trial. Therefore, there are needs for safe and effective RDN strategies considering the anatomical structure of the renal arteries and sympathetic nerves. In this paper, we propose a novel surgical instruments for laparoscopic renal denervation (RDN) to treat of resistant hypertension through a 3D realistic model using nephrectomy tissues. Laparoscopic RDN is a new surgical approach to remove renal sympathetic nerves.1