The Mx/G/1 queue with queue length dependent service times

We deal with the MX/G/1 queue where service times depend on the queue length at the service initiation. By using Markov renewal theory, we derive the queue length distribution at departure epochs. We also obtain the transient queue length distribution at time t and its limiting distribution and the virtual waiting time distribution. The numerical results for transient mean queue length and queue length distributions are given.Bong Dae Choi, Yeong Cheol Kim, Yang Woo Shin, and Charles E. M. Pearc

Analytical model of IEEE 802.15.4 non-beacon mode with download traffic by the piggyback method

Abstract. We analyze the MAC performance of the IEEE 802.15.4 LR-WPAN non-beacon mode with the piggyback method in non-saturated condition. Our approach is to model a stochastic behavior of one device as a discrete time Markov chain. We propose an analytical model describing the download behavior of a device using piggyback method. We obtain the performance measures such as throughput, packet delay, energy consumption and packet loss probability of a device. Numerical results and simulation results show that the piggyback method which removes a backoff procedure in the backoff method can reduce the delay, loss probability and energy consumption compared with backoff method. Our results can be used to find the optimal number of devices with some constraints on packet delay and packet loss probability

An optimal admission control protocol for heterogeneous multicast streaming services

We investigate optimal call admission control (CAC) policy for multicast streaming services (MSS) in 3rd generation (3G) and beyond wireless mobile networks. Several MSS sessions are supported simultaneously in a bandwidth-limited network. Active sessions are those that are currently serving some users, and inactive sessions are those that are currently not serving any users. An admission decision in MSS is required only when an inactive session is requested, unlike in unicasting. For this reason, if a user request for an inactive MSS session arrives, we should make an admission decision in anticipation of (i) the possible reward earned based on users served during a session active time generated by accepting it, and (ii) the influence of the session active time upon the future status of network bandwidth and admission decisions. Our objective is to determine when to admit or block a user asking an inactive MSS session to achieve the optimality in rewards. We formulate this problem as a semi-Markov decision process (SMDP), and a value iteration algorithm is used to obtain an optimal stationary deterministic policy. We also derive the user blocking probability of the optimal policy by analyzing an embedded Markov chain induced by it.http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=26hb201

Performance Analysis of IEEE 802.15.4 with Non-beacon enabled CSMA/CA

Abstract. This paper proposes an analytical model of IEEE 802.15.4, which is a standard toward low complexity, low power consumption and low data rate wireless data connectivity. In this paper, we concentrate on the MAC performance of the IEEE 802.15.4 LR-WPAN in a star topology with unslotted CSMA/CA channel access mechanism under non-saturated modes. Our approach is to model stochastic behavior of one device as a discrete time Markov chain model. We believe that many WSN applications would benefit from our analytical model because many applications in WSN generate traffic in non-saturated mode. We obtain five performance measures : throughput, packet delay, number of backoff, energy consumption and packet loss probability. Our results are used to find optimal number of devices satisfying some QoS requirements

Mst1-FoxO Signaling Protects Naïve T Lymphocytes from Cellular Oxidative Stress in Mice

Background: The Ste-20 family kinase Hippo restricts cell proliferation and promotes apoptosis for proper organ development in Drosophila. InC. elegans, Hippo homolog also regulates longevity. The mammalian Ste20-like protein kinase, Mst1, plays a role in apoptosis induced by various types of apoptotic stress. Mst1 also regulates peripheral naïve T cell trafficking and proliferation in mice. However, its functions in mammals are not fully understood. Methodology/Principal Findings: Here, we report that the Mst1-FoxO signaling pathway plays a crucial role in survival, but not apoptosis, of naïve T cells. In Mst1 2/2 mice, peripheral T cells showed impaired FoxO1/3 activation and decreased FoxO protein levels. Consistently, the FoxO targets, Sod2 and catalase, were significantly down-regulated in Mst1 2/2 T cells, thereby resulting in elevated levels of intracellular reactive oxygen species (ROS) and induction of apoptosis. Expression of constitutively active FoxO3a restored Mst1 2/2 T cell survival. Crossing Mst1 transgenic mice (Mst1 Tg) with Mst1 2/2 mice reduced ROS levels and restored normal numbers of peripheral naïve T cells in Mst1 Tg;Mst1 2/2 progeny. Interestingly, peripheral T cells from Mst1 2/2 mice were hypersensitive to c-irradiation and paraquat-induced oxidative stresses, whereas those from Mst1 Tg mice were resistant. Conclusions/Significance: These data support the hypothesis that tolerance to increased levels of intracellular RO

Interferometric detection of prostate specific antigen based on enzyme immunoassay

AbstractInterferometric detection of Prostate-specific antigen (PSA) based on enzyme immunoassay are investigated. Refractive index changes of substrate are measured for PSA detection. Michelson scheme of optical interferometer was used so as to be applicable to a disposable fluidic chip. When interferometer is used for the measurements of refractive index changes, the detection is over 8 times more sensitive than that of absorbance changes for the same amount of target protein

Grand Rounds: An Outbreak of Toxic Hepatitis among Industrial Waste Disposal Workers

CONTEXT: Industrial waste (which is composed of various toxic chemicals), changes to the disposal process, and addition of chemicals should all be monitored and controlled carefully in the industrial waste industry to reduce the health hazard to workers. CASE PRESENTATION: Five workers in an industrial waste plant developed acute toxic hepatitis, one of whom died after 3 months due to fulminant hepatitis. In the plant, we detected several chemicals with hepatotoxic potential, including pyridine, dimethylformamide, dimethylacetamide, and methylenedianiline. The workers had been working in the high-vapor-generating area of the plant, and the findings of pathologic examination showed typical features of acute toxic hepatitis. DISCUSSION: Infectious hepatitis and drug-induced hepatitis were excluded by laboratory findings, as well as the clinical course of hepatitis. All cases of toxic hepatitis in this plant developed after the change of the disposal process to thermochemical reaction–type treatment using unslaked lime reacted with industrial wastes. During this chemical reaction, vapor containing several toxic materials was generated. Although we could not confirm the definitive causative chemical, we suspect that these cases of hepatitis were caused by one of the hepatotoxic agents or by a synergistic interaction among several of them. RELEVANCE TO CLINICAL OR PROFESSIONAL PRACTICE: In the industrial waste treatment process, the danger of developing toxic hepatitis should be kept in mind, because any subtle change of the treatment process can generate various toxic materials and threaten the workers’ health. A mixture of hepatotoxic chemicals can induce clinical manifestations that are quite different from those predicted by the toxic property of a single agent