Decomposition of Incident and Reflected Regular Wave Using One Moving Wave Gage

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

PCT-CycleGAN: Paired Complementary Temporal Cycle-Consistent Adversarial Networks for Radar-Based Precipitation Nowcasting

The precipitation nowcasting methods have been elaborated over the centuries because rain has a crucial impact on human life. Not only quantitative precipitation forecast (QPF) models and convolutional long short-term memory (ConvLSTM), but also various sophisticated methods such as the latest MetNet-2 are emerging. In this paper, we propose a paired complementary temporal cycle-consistent adversarial networks (PCT-CycleGAN) for radar-based precipitation nowcasting, inspired by cycle-consistent adversarial networks (CycleGAN), which shows strong performance in image-to-image translation. PCT-CycleGAN generates temporal causality using two generator networks with forward and backward temporal dynamics in paired complementary cycles. Each generator network learns a huge number of one-to-one mappings about time-dependent radar-based precipitation data to approximate a mapping function representing the temporal dynamics in each direction. To create robust temporal causality between paired complementary cycles, novel connection loss is proposed. And torrential loss to cover exceptional heavy rain events is also proposed. The generator network learning forward temporal dynamics in PCT-CycleGAN generates radar-based precipitation data 10 minutes from the current time. Also, it provides a reliable prediction of up to 2 hours with iterative forecasting. The superiority of PCT-CycleGAN is demonstrated through qualitative and quantitative comparisons with several previous methods.Comment: CIKM 202

2-D Equivalent finite element model of quadratic linear electromagnetic actuator

The purpose of this paper is to present a 2-D equivalent finite element model of a quadratic linear electromagnetic actuator that can save space and power as it does not employ an energy conversion system. A 2-D model, while being fairly accurate, is preferable to a 3-D finite element analysis for the design and analysis of a quadratic linear electromagnetic actuator as it requires significantly lower computing resources and results in faster calculations. We calculate the effective coil length for the equivalent 2-D finite element model and validate the accuracy of this model with experimental data

Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP

Cyclin Y (CCNY) is a member of the cyclin protein family, known to regulate cell division in proliferating cells. Interestingly, CCNY is expressed in neurons that do not undergo cell division. Here, we report that CCNY negatively regulates long-term potentiation (LTP) of synaptic strength through inhibition of AMPA receptor trafficking. CCNY is enriched in postsynaptic fractions from rat forebrain and is localized adjacent to postsynaptic sites in dendritic spines in rat hippocampal neurons. Using live-cell imaging of a pH-sensitive AMPA receptor, we found that during LTP-inducing stimulation, CCNY inhibits AMPA receptor exocytosis in dendritic spines. Furthermore, CCNY abolishes LTP in hippocampal slices. Taken together, our findings demonstrate that CCNY inhibits plasticity-induced AMPA receptor delivery to synapses and thereby blocks LTP, identifying a novel function for CCNY in post-mitotic cells

Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids.

Human pluripotent stem cell (hPSC)-derived intestinal organoids (hIOs) form 3D structures organized into crypt and villus domains, making them an excellent in vitro model system for studying human intestinal development and disease. However, hPSC-derived hIOs still require in vivo maturation to fully recapitulate adult intestine, with the mechanism of maturation remaining elusive. Here, we show that the co-culture with human T lymphocytes induce the in vitro maturation of hIOs, and identify STAT3-activating interleukin-2 (IL-2) as the major factor inducing maturation. hIOs exposed to IL-2 closely mimic the adult intestinal epithelium and have comparable expression levels of mature intestinal markers, as well as increased intestine-specific functional activities. Even after in vivo engraftment, in vitro-matured hIOs retain their maturation status. The results of our study demonstrate that STAT3 signaling can induce the maturation of hIOs in vitro, thereby circumventing the need for animal models and in vivo maturation

β-Caryophyllene attenuates dextran sulfate sodium-induced colitis in mice via modulation of gene expression associated mainly with colon inflammation

AbstractWe examined the modulatory activity of β-caryophyllene (CA) and gene expression in colitic colon tissues in a dextran sulfate sodium (DSS)-induced colitis model. Experimental colitis was induced by exposing male BALB/c mice to 5% DSS in drinking water for 7 days. CA (30 or 300mg/kg) was administered orally once a day together with DSS. CA administration attenuated the increases in the disease activity index, colon weight/length ratio, inflammation score, and myeloperoxidase activity in DSS-treated mice. Microarray analysis showed that CA administration regulated the expression in colon tissue of inflammation-related genes including those for cytokines and chemokines (Ccl2, Ccl7, Ccl11, Ifitm3, IL-1β, IL-28, Tnfrsf1b, Tnfrsf12a); acute-phase proteins (S100a8, Saa3, Hp); adhesion molecules (Cd14, Cd55, Cd68, Mmp3, Mmp10, Sema6b, Sema7a, Anax13); and signal regulatory proteins induced by DSS. CA significantly suppressed NF-κB activity, which mediates the expression of a different set of genes. These results suggest that CA attenuates DSS-induced colitis, possibly by modulating the expression of genes associated mainly with colon inflammation through inhibition of DSS-induced NF-κB activity

Low Skeletal Muscle Mass and Clinical Outcomes in Chronic Obstructive Pulmonary Disease

Background In patients with chronic obstructive pulmonary disease (COPD), decreased muscle mass is a frequently encountered comorbidity in clinical practice. However, the evaluation of muscle mass in patients with COPD in real-world practice is rare. Methods We retrospectively reviewed the electronic medical records of all patients with COPD who underwent bioelectrical impedance analysis at least once between January 2011 and December 2021 in three hospitals. Then, we analyzed the performance rate of muscle mass measurement in the patients and the correlation between muscle mass, clinical parameters, and COPD prognosis. Results Among the 24,502 patients with COPD, only 270 (1.1%) underwent muscle mass measurements. The total skeletal muscle mass index was significantly correlated with albumin, alanine transaminase, and creatinine to cystatin C ratio in patients with COPD (r=0.1614, p=0.011; r=0.2112, p=0.001; and r=0.3671, p=0.001, respectively). Acute exacerbation of COPD (AE COPD) was significantly correlated with muscle mass, especially the truncal skeletal muscle mass index (TSMI) in males (r=–0.196, p=0.007). In the multivariate analysis, TSMI and cystatin C were significant risk factors for AE COPD (hazard ratio, 0.200 [95% confidence interval, CI, 0.048 to 0.838] and 4.990 [95% CI, 1.070 to 23.278], respectively). Conclusion Low muscle mass negatively affects the clinical outcomes in patients with COPD. Despite its clinical significance, muscle mass measurement is performed in a small proportion of patients with COPD. Therefore, protocols and guidelines for the screening of sarcopenia in patients with COPD should be established

Linear Wave Reflection by Trench with Various Shapes

author's final versionTwo types of analytical solutions for waves propagating over an asymmetric trench are derived. One is a shallow water wave model and the other is an extended model applicable to deeper water. The water depth inside the trench varies in proportion to a power of distance from the center of the trench (where the center means the deepest water depth point and the origin of -coordinate in this study). The mild-slope equation is transformed into a second order ordinary differential equation with variable coefficients based on the longwave assumption or Hunts (1979) approximate solution for wave dispersion. The analytical solutions are then obtained by using the power series technique. The analytical solutions are compared with the numerical solution of the hyperbolic mild-slope equations. After obtaining the analytical solutions under various conditions, the results are analyzed