32 research outputs found

    Evolution of a filmmaker

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    Thesis (M.S.V.S.)--Massachusetts Institute of Technology, Dept. of Architecture, 1980.MICROFICHE COPY AVAILABLE IN ARCHIVES AND ROTCH.Includes bibliographical references.by John Chittick.M.S.V.S

    The effect of screen ruling on the saturation of pastel gamut colors

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    Reproduction of pastel colors by offset lithography produces images that have less color saturation than their continuous tone counterparts. This problem is primarily attributable to the halftone structure which approximates continuous tone pastels with large amounts of white paper and small amounts of chromatic ink. This thesis investigates the effect of screen frequency upon pastel color saturation. Single and two color overprint tints of nominal five, 10, and 15 percent printing dot areas were printed in 85, 100, 120, 133, 150, and 200 lines screen rulings. The reflectances of these colors were measured with a colorimeter and converted to CIEL*a*b* color notation to provide metric lightness and the chromatic co-ordinates from which chroma was calculated. Physical dot area was calculated by the Yule- Nielson equation for each single color patch. A more complicated graphical technique was used to find this data for the overprint colors of the same physical dot areas. For both single and overprint colors, as screen ruling becomes progressively finer, pastel saturation increased with physical dot area held constant. For this experiment, the average chroma difference at the 10 percent physical dot area between the coarsest and finest line screen ruling is 2 chroma units. This difference could also be achieved by changing physical dot area by one percent. The amount of saturation increase is dot area and hue dependent. The yellow printer showed the greatest saturation increase. The saturation increase increased with dot area for a given screen frequency. 2 Lightness decreased whenever saturation increased. When the saturation associated with the different screen rulings were compared at equal darknesses, an increase in saturation could not be statistically determined. The saturation increase from increased screen ruling at equal physical dot areas occurs because of the increased ink/light/paper interaction. Optical dot area is calculated by the Murray·Davies equation which does not compensate for this change in optical interaction. The experiment shows that at equal optical dot areas, chroma will be the same regardless of screen ruling

    Living God Pandeism: Evidential Support

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    Pandeism is the belief that God chose to wholly become our Universe, imposing principles at this Becoming that have fostered the lawful evolution of multifarious structures, including life and consciousness. This article describes and defends a particular form of pandeism: living God pandeism (LGP). On LGP, our Universe inherits all of God's unsurpassable attributes—reality, unity, consciousness, knowledge, intelligence, and effectiveness—and includes as much reality, conscious and unconscious, as is possible consistent with retaining those attributes. God and the Universe, together “God-and-Universe,” is also eternal into the future and the past. The article derives testable hypotheses from these claims and shows that the evidence to date confirms some of these while falsifying none. Theism cannot be tested in the same way

    Pharmacokinetics of Tenofovir Disoproxil Fumarate and Ritonavir-Boosted Saquinavir Mesylate Administered Alone or in Combination at Steady State

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    A phase I study was conducted to formally evaluate the steady-state pharmacokinetics (PK) of tenofovir disoproxil fumarate (TDF) and ritonavir (RTV)-boosted saquinavir mesylate (SQV) when coadministered in healthy volunteers. Forty subjects received multiple doses of TDF (300 mg, once daily) and SQV/RTV (1,000 mg/100 mg, twice daily) alone and together under steady-state conditions in an open-label, fixed sequence design. Blood samples for tenofovir (TFV) and SQV/RTV PK were drawn over respective 24- and 12-h dosing intervals, and drug concentrations were measured by liquid chromatography-tandem mass spectrometry. Safety was assessed periodically by clinical and laboratory monitoring. Thirty-two subjects completed the study and were fully evaluable; three subjects discontinued participation in the study due to adverse events, three subjects withdrew for personal reasons, and two subjects withdrew because of inadequate venous access for blood sampling. Steady-state TFV PK were not significantly altered upon coadministration with SQV/RTV. Steady-state SQV (administered as SQV/RTV) AUC(tau), C(max), and C(tau) increased 29, 22, and 47%, respectively, upon coadministration with TDF, and all subjects achieved a C(tau) of >100 ng/ml. These modestly increased SQV exposures are not clinically meaningful given its clinical use with RTV already results in >10-fold-higher SQV levels. Steady-state RTV AUC(tau) and C(max) levels were not significantly altered, whereas C(tau) was 23% higher upon coadministration of SQV/RTV and TDF. Thus, no clinically relevant interactions between TDF and RTV-boosted SQV were observed under conditions simulating clinical practice
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