International Journal of Pharma and Bio Sciences RESEARCH ARTICLE BIOCHEMISTRY ‘COMPARATIVE ASSESSMENT OF INSULIN SENSITIVITY AND PANCREATIC BETA CELL FUNCTION IN DIABETICS AND NON-DIABETICS’

The study was carried out to evaluate and compare insulin resistance, pancreatic beta cell dysfunction and lipid profile in non-diabetic first degree relatives of type 2 diabetics and also to evaluate the same parameters in diabetics with varying duration. 190 subjects were taken and categorized based on duration of diabetes. Fasting blood sugar (F.B.S.L.), Post prandial blood sugar (P.P.B.S.L.), Glycated haemoglobin (HbA1c), plasma insulin, insulin resistance, beta cell dysfunction and lipid profile was estimated. Results showed a significant difference in insulin resistance and no significant difference in beta cell dysfunction in non-diabetic first degree relatives. Insulin resistance was found to increase and beta cell function decrease significantly. No significant difference was observed between Low density and High density lipoprotein cholesterol levels between first degree relatives and controls while other lipid parameters showed a significant change. A good correlation was observed of insulin with insulin resistance, FBSL and HbA1c. This article can be downloaded from www.ijpbs.ne

ANTIOXIDANT STATUS IN NON-INSULIN DEPENDENT DIABETES MELLITUS

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International Journal of Pharma and Bio Sciences RESEARCH ARTICLE BIOCHEMISTRY “HYPOMAGNESEMIA IN ALCOHOL DEPENDENT POPULATION FROM THE LOWER SOCIO-ECONOMIC BACKGROUND WHO WERE CONSUMING ILLICIT LIQUOR AND ATTENDING THE DE-ADDICTION CENTER”.

Magnesium is intimately involved in over 300 enzymatic reactions, particularly in processes involving the formation and utilization of ATP. It is also a known fact that alcoholism is associated with hypomagnesaemia. The present study determines the significance of routine serum magnesium determination in alcoholic patients consuming illicit liquor from lower socio-economic background attending deaddiction centre. Serum magnesium, sodium and potassium concentrations in 200 chronic alcoholic patients consuming illicit liquor from lower socio-economic background admitted to the deaddiction centre were estimated and compared to 158 healthy nonalcoholic controls. Serum magnesium levels were significantly decreased whereas serum transaminases and gammaglutamyl transpeptidases were increased in alcoholic patients compared to healthy nonalcoholic controls.Hypomagnesemia could be due to the increased oxidative stress and might be a risk factor in the progression of fatty liver to steatohepatitis.The results of the present investigation support the practice of routine magnesium administration to chronic alcoholics. This article can be downloaded from www.ijpbs.ne