Juvenile myelomonocytic leukemia (JMML)

Review on juvenile myelomonocytic leukemia, with data on clinics, pathology, and involved genes

Infant leukaemias,Congenital leukaemias,Neonatal leukaemias

Review on congenital/neonatal and infant leukemias, with data on clinics, pathology, and involved genes

Systemic EBV-positive T-cell lymphoma of childhood

Review on systemic EBV positive T-cell lymphoma of childhood, with data on clinical findings, pathology and genetic alterations

Myeloid proliferations in Down syndrome

Review on myeloid proliferations related to Down syndrome, with data on clinics, pathology, and involved genes

Myeloid sarcoma

Review on myeloid sarcoma, with data on clinics, pathology, and involved genes

Down syndrome

Review on Down syndrome, with data on clinics, susceptibility to neoplasms, and the genes involve

Acute lymphoblastic leukemia in Down syndrome

Review on acute lymphoblastic leukemia in Down syndrome, with data on clinics, pathology, and involved genes

Cutaneous mastocytosis

Review on cutaneous mastocytosis, with data on clinics, pathology, and involved genes

The impact of the National HIV Health Care Worker Hotline on patient care in South Africa

<p>Abstract</p> <p>Background</p> <p>South Africa has a huge burden of illness due to HIV infection. Many health care workers managing HIV infected patients, particularly those in rural areas and primary care health facilities, have minimal access to information resources and to advice and support from experienced clinicians. The Medicines Information Centre, based in the Division of Clinical Pharmacology at the University of Cape Town, has been running the National HIV Health Care Worker (HCW) Hotline since 2008, providing free information for HIV treatment-related queries via telephone, fax and e-mail.</p> <p>Results</p> <p>A questionnaire-based study showed that 224 (44%) of the 511 calls that were received by the hotline during the 2-month study period were patient-specific. Ninety-four completed questionnaires were included in the analysis. Of these, 72 (77%) were from doctors, 13 (14%) from pharmacists and 9 (10%) from nurses. 96% of the callers surveyed took an action based on the advice received from the National HIV HCW Hotline. The majority of actions concerned the start, dose adaption, change, or discontinuation of medicines. Less frequent actions taken were adherence and lifestyle counselling, further investigations, referring or admission of patients.</p> <p>Conclusions</p> <p>The information provided by the National HIV HCW Hotline on patient-specific requests has a direct impact on the management of patients.</p

dictyBase, the model organism database for Dictyostelium discoideum

dictyBase () is the model organism database (MOD) for the social amoeba Dictyostelium discoideum. The unique biology and phylogenetic position of Dictyostelium offer a great opportunity to gain knowledge of processes not characterized in other organisms. The recent completion of the 34 MB genome sequence, together with the sizable scientific literature using Dictyostelium as a research organism, provided the necessary tools to create a well-annotated genome. dictyBase has leveraged software developed by the Saccharomyces Genome Database and the Generic Model Organism Database project. This has reduced the time required to develop a full-featured MOD and greatly facilitated our ability to focus on annotation and providing new functionality. We hope that manual curation of the Dictyostelium genome will facilitate the annotation of other genomes