Evaluarea preciziei şi acurateţii unei metode spectrofotometricede măsurare a concentraţiei compusului activ în forme farmaceutice

A spectrophotometric method in visible range measuringthe active compoundcontent of pharmaceutical tablets was developed and proposed to be validated and applied. The analysis method was highly precise(presenting the relative standard deviation values within the accepted range of values, RSD ≤ 5%), and highly accurate(presenting the average recovery and average relative error value located within the accepted range of values, Xdm≤ 5)

Metoda de analiză spectrofotometrică a metamizolului din tabletele farmaceutice: investigarea linearităţii, a limitei de detecţie şi a limitei de cuantificare

The aim of this research was to exactly quantify the pure sodium metamizole content frompharmaceutical tablets, by using a spectro-photometric analysis method in visible range. The method applied has been subjected to a validation protocol which consisted in analyzing the following parameters: linearity of the method, limit of detection (LD) and limit of quantification (LQ). The pure sodium metamizole amount in a pharmaceutical tablet was found to be 477.477 mg, assigned to a percentage content of 95.495 %, close to official declared amount (500 mg), presentingan average percentage deviation of 4.505 % from the officiallystatedactive substance content. This value was situated below the maximum admissible percentage deviation of active substance content (± 5%), stated by Romanian Pharmacopeia, X-thEdition

Un model matematic al creşterii bacteriilor utilizând comunităţile bacteriene din sol

A bacterial growth model is presented starting from the Malthusian model of exponential growth. Considering the growth rate being a linear function, we can express it using the bacterial tolerance grade over different conditions. Resolving the obtained differential equation, we plot the growth of the bacterial population for the studied initial conditions. The numerical increase of soil bacterial population cultivated on common microbiological growth media (Potato dextrose agar –abbreviated PDA) is studied

Comparison Adsorption of Cd (II) onto Lignin and Polysaccharide-Based Polymers

Given the predominantly negative impact of heavy metals on living organisms, the present study proposed to evaluate the adsorption performances under static conditions of Cd (II) from aqueous solutions on unmodified Sarkanda grass lignin compared to the adsorption performances of polysaccharide polymers chemically functionalized, obtained by synthesis and in their native state, but which, although effective, have a cost price that does not allow for large-scale expansion. To improve the retention of Cd (II) on this aromatic component of the biomass resulting from the processing of lignocellulosic materials, different experimental conditions (pH, concentration, dose and contact time) were followed. The Freundlich and Langmuir isotherms were used to describe the equilibrium conditions. Adsorption kinetics were assessed using the Lagergren I and Ho and McKay II kinetic models, furnishing informative insights into the process mechanism. Lignin adsorption capacity was also analyzed by performing biological tests on tomato seeds (Lypercosium esculentum), since heavy metals are known to be a stress factor for seeds by disturbing the osmotic equilibrium. Through the prism of the investigated parameters and under precisely established experimental conditions, unmodified Sarkanda grass lignin—an aromatic biopolymer—can be recommended as a promising adsorbent for the retention of Cd (II) from aqueous solutions, successfully replacing polysaccharide, especially cellulose-based polymers