Uncovering resistance to microtubule targeting drugs

Drugs that alter microtubule dynamics have been used for decades for treating different types of cancers. Such drugs arrest cell cycle progression in mitosis, and induce apoptosis. However, a fraction of cells manages to survive, escapes from the arrest and resumes proliferation. Understanding the strategies of these cells is important to uncover the early stages of emergence of resistance. To this aim, we performed laboratory evolution experiments in yeast and in mammalian cells when microtubule dynamics is impaired. Our results show that cells follow reproducible strategies to escape the effect of the drug. Via mutations, aneuplouidy and non genetics mechanisms they recover microtubule functionality and decrease the propensity to die.Book of abstract: 4th Belgrade Bioinformatics Conference, June 19-23, 202

Objectives and Concepts of the European Ground Systems Common Core (EGS-CC)

The European Ground Systems – Common Core (EGS-CC) is a European initiative to develop a common infrastructure to support space systems monitoring and control in preand post-launch phases for all mission types. This will bring a number of benefits, such as the seamless transition from spacecraft Assembly, Integration and Testing (AIT) to mission operations, reduce cost and risk, support the modernisation of legacy systems and promote the exchange of ancillary implementations across organizations. The initiative is being undertaken as a collaboration of ESA, European National Agencies and European Prime Industry. In this paper we describe the main objectives of the EGS-CC initiative, the overall system concept and the features it will provide