Virological and Epidemiological Studies on Encephalitis in Chiang Mai Area, Thailand, in the Year of 1982 : III. Virus isolation from clinical materials

1982年7月19日から8月17日までの調査期間中,3例の死亡した脳炎患者中1検体から1株の日本脳炎ウイルスが分離された.一方患者末梢血177検体からデングウイルスは11株分離され,単一クローン抗体による型同定で8株は1型,2株は2型,1株は3型である事が判明した.脳炎あるいは髄膜炎と診断された患者からデングウイルスが分離されたことはデング脳症の存在を示すものと考えられる.Japanese encephalitis (JE) virus was isolated from one out of 3 postmortem brain materials taken as necropsy specimens, while 11 strains of dengue viruses were isolated from peripheral blood of 9 dengue hemorrhagic fever (DHF), 1 encephalitis and 1 aseptic meningitis patients, during study period from July 19 to August 17, 1982. Typing by monoclones revealed that 8 strains were type 1, 2 were type 2, and 1 was type 3 virus, respectively. Isolation of dengue viruses from encephalitis and meningitis cases appears to indicate the presence of dengue encephalopathy

Virological and Epidemiological Studies on Encephalitis in Chiang Mai Area, Thailand, in the Year of 1982 : II. Hospitalized patients

1982年7月17日から8月19日までタイ国チェンマイ地区において179名の入院患者を観察した.患者の臨床診断は脳炎55名,デング出血熱(DHF)77名,不明熱11名,髄膜炎8名,その他および臨床診断名のない患者28名である. DHFの大部分はチェンマイ市において一時期に集中的に見られたのに対し,脳炎患者はチェンマイ県全体に散在性に見られ,その発生時期も調査期間を通じて散発的に認められた.この調査で得られた脳炎およびDHF患者の年令分布はタイ国全体の平均に比べて高年令側に偏していた.A total of 179 hospitalized patients were observed during the study period from July 17 to August 19, 1982, in Chiang Mai Area, Thailand. Their clinical diagnoses were 55 encephalitis, 77 dengue hemorrhagic fever (DHF), 11 fever of unknown origin, 8 meningitis, and 28 other diseases or without clinical diagnosis. DHF cases were observed mostly in Chiang Mai City and were concentrated in a short period of time, while encephalitis cases were more scattered over Chiang Mai Province and were observed more sporadically during the study period. Age distribution of the observed encephalitis and DHF patients appeared to have a shift toward older age when compared with the average in Thailand

Comparison between a linear versus a macrocyclic contrast agent for whole body MR angiography in a clinical routine setting

<p>Abstract</p> <p>Background</p> <p>Previous experiences of whole body MR angiography are predominantly available in linear 0.5 M gadolinium-containing contrast agents. The aim of this study was to compare image quality on a four-point scale (range 1–4) and diagnostic accuracy of a 1.0 M macrocyclic contrast agent (gadobutrol, n = 80 patients) with a 0.5 M linear contrast agent (gadopentetate dimeglumine, n = 85 patients) on a 1.5 T whole body MR system. Digital subtraction angiography served as standard of reference.</p> <p>Results</p> <p>All examinations yielded diagnostic image quality. There was no significant difference in image quality (3.76 ± 0.3 versus 3.78 ± 0.3, p = n.s.) and diagnostic accuracy observed. Sensitivity and specificity of the detection of hemodynamically relevant stenoses was 93%/95% in the gadopentetate dimeglumine group and 94%/94% in the gadobutrol group, respectively.</p> <p>Conclusion</p> <p>The high diagnostic accuracy of gadobutrol in the clinical routine setting is of high interest as medical authorities (e.g. the European Agency for the Evaluation of Medicinal Products) recommend macrocyclic contrast agents especially to be used in patients with renal failure or dialysis.</p

Serodiagnosis by the ELISA on Encephalitis in Chiang Mai, Thailand, 1983

1983年の流行期にタイ国チェンマイにおいて114例の脳炎患者から採血した142検体の血清について日本脳炎(JE)とデングウイルス2型抗原に対する抗体価をELISAによって測定した結果,IgM-ELISAによって17例はJE,12例は多分デング脳症と診断された.JEの年令分布は10-14才にピークを示したが,デング脳症は10-49才とより高年令側に分布した.JE抗原に対する間接IgG-ELISAによって26例はフラビウイルスの2次感染と考えられ,その年令分布は10-14才に最も多く存在した.One hundred forty two serum specimens from 114 encephalitis cases in Chiang Mai, Thailand collected during epidemic period in 1983, were measured for their antibody titers against Japanese encephalitis (JE) and dengue virus type 2 antigens by the ELISA. Seventeen cases were diagnosed as JE, while 12 were considered as possible dengue encephalopathy by IgM-ELISA. Age distribution of JE cases showed its peak in the group of 10-14 years old, while possible dengue encephalopathy distributed from 10 up to 49 years old. Indirect IgG-ELISA using JE antigen detected 26 cases of secondary flavivirus infections, with highest incidence in 10-14 years old