cis-Bis[(4-nitro­phen­yl)cyanamido-κN 1]bis­(1,10-phenanthroline-κ2 N,N′)nickel(II) methanol monosolvate

In the title compound, [Ni(C7H4N3O2)2(C12H8N2)2]·CH3OH, the NiII atom is six-coordinated in a distorted N6 octa­hedral geometry and is chelated by two phenanthroline ligands and two phenyl­cyanamide groups which occupy cis positions. The (4-nitro­phen­yl)cyanamide anions act as monodentate ligands. There is one classical inter­molecular O—H⋯N hydrogen bond and several C—H⋯O hydrogen bonds are also observed

catena-Poly[[(dimethyl­formamide-κO)copper(II)]-bis­(μ-4-nitro­phenyl­cyanamido-κ2 N 1:N 3)]

In the title compound, [Cu(C7H4N3O2)2(C3H7NO)], the CuII atom is five-coordinated in a distorted square-pyramidal geometry, with the N atoms in equatorial positions and the dimethyl­formamide O atom in an axial position. The dihedral angle between adjacent benzene rings is 70.33 (12)°

catena-Poly[[(dimethyl­formamide-κO)cobalt(II)]-bis­[μ-(4-nitro­phenyl)­cyanamido]-κ2 N 1:N 3;κ2 N 3:N 1]

In the title coordination polymer, [Co(C7H4N3O2)2(C3H7NO)]n, the CoII atom is five-coordinated in a distorted square-pyramidal CoON4 geometry with the O atom from a dimethyl­formamide mol­ecule in an equatorial position. The bridging phenyl­cyanamide anions generate an infinite chain propagating in [001]

New cyclometalated ir(iii) complexes with ncn pincer and meso-phenylcyanamide bodipy ligands as efficient photodynamic therapy agents

A new class of cyclometalated iridium((III)) with NCN pincer and meso-phenylcyanamide BODIPY ligands of the formula [Ir(L)(PPY)(Pcyd-BODIPY)], 1, [Ir(L)(PIQ)(Pcyd-BODIPY)], 2, in which HL: 5-methoxy-1,3-bis (1-methyl-1H-benzo[d]imidazol-2-yl) benzene, Pcyd-BODIPY: 8-(4-phenylcyanamide) BODIPY, PPY: 2-phenylpyridine, PIQ: 1-phenylisoquinoline have been synthesized and studied for photodynamic therapy (PDT). The photophysical properties, DNA binding, DNA photocleavage, cellular uptake, thioredoxin reductase activity, reactive oxygen species (ROS) generation, and cellular apoptosis of the complexes have also been studied. Therefore, we present a conceivable biologically applicable PDT modality that develops persuasively designed photoactivatable Ir((III)) complexes

New cyclometalated ir(iii) complexes with ncn pincer and meso-phenylcyanamide bodipy ligands as efficient photodynamic therapy agents

A new class of cyclometalated iridium((III)) with NCN pincer and meso-phenylcyanamide BODIPY ligands of the formula [Ir(L)(PPY)(Pcyd-BODIPY)], 1, [Ir(L)(PIQ)(Pcyd-BODIPY)], 2, in which HL: 5-methoxy-1,3-bis (1-methyl-1H-benzo[d]imidazol-2-yl) benzene, Pcyd-BODIPY: 8-(4-phenylcyanamide) BODIPY, PPY: 2-phenylpyridine, PIQ: 1-phenylisoquinoline have been synthesized and studied for photodynamic therapy (PDT). The photophysical properties, DNA binding, DNA photocleavage, cellular uptake, thioredoxin reductase activity, reactive oxygen species (ROS) generation, and cellular apoptosis of the complexes have also been studied. Therefore, we present a conceivable biologically applicable PDT modality that develops persuasively designed photoactivatable Ir((III)) complexes

Cytotoxicity and antimicrobial activity of triorganotin(IV) complexes of phenylcyanamide prepared by sonochemical synthesis

This article describes the synthesis and characterization of novel triorganotin(IV) complexes and their potential medicinal applications. Triorganotin(IV) complexes with formulas [(SnMe3)(2)(mu-bp)(H2O)(2)], 1, and [(SnMe3)(4-NO(2)pcyd)], 2, (Me: methyl, bpH(2): 4,4'-dicyanamidobiphenyl and 4-NO(2)pcyd: 4-nitrophenylcyanamide) have been synthesized via a sonochemical process and characterized using multinuclear NMR (H-1, C-13 and Sn-119), Mossbauer spectroscopy, elemental analysis, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Compounds 1 and 2 were evaluated for their DNA/protein binding with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA), respectively. The in vitro cytotoxicity of 1 and 2 was examined against A549, Du145, HeLa and MCF-7 cancer cell lines. For 1, a promising growth inhibitory effect against HeLa cells was observed that is slightly higher than that of cisplatin. Moreover, the antimicrobial activity of 1 and 2 against different strains of pathogenic bacteria and fungi were tested. The free radical scavenging ability (OH, NO) of 1 and 2 was assessed. (C) 2015 Elsevier B.V. All rights reserved.We are grateful for the financial support from the Department of Chemistry, Isfahan University Of Technology (IUT).peer-reviewed2017-09-2

Cytotoxicity and antimicrobial activity of triorganotin(IV) complexes of phenylcyanamide prepared by sonochemical synthesis

This article describes the synthesis and characterization of novel triorganotin(IV) complexes and their potential medicinal applications. Triorganotin(IV) complexes with formulas [(SnMe3)(2)(mu-bp)(H2O)(2)], 1, and [(SnMe3)(4-NO(2)pcyd)], 2, (Me: methyl, bpH(2): 4,4\u27-dicyanamidobiphenyl and 4-NO(2)pcyd: 4-nitrophenylcyanamide) have been synthesized via a sonochemical process and characterized using multinuclear NMR (H-1, C-13 and Sn-119), Mossbauer spectroscopy, elemental analysis, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Compounds 1 and 2 were evaluated for their DNA/protein binding with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA), respectively. The in vitro cytotoxicity of 1 and 2 was examined against A549, Du145, HeLa and MCF-7 cancer cell lines. For 1, a promising growth inhibitory effect against HeLa cells was observed that is slightly higher than that of cisplatin. Moreover, the antimicrobial activity of 1 and 2 against different strains of pathogenic bacteria and fungi were tested. The free radical scavenging ability (OH, NO) of 1 and 2 was assessed. (C) 2015 Elsevier B.V. All rights reserved.We are grateful for the financial support from the Department of Chemistry, Isfahan University Of Technology (IUT).2017-09-2