High Impact IS Papers and Researchers in the Pacific Asia Region

As research in information systems (IS) becomes increasingly popular, it is interesting to know the impact of research from the Pacific Asia region and who has contributed more high impact papers. With the assistance of SSCI/SCIE database of Web of Science and Google Scholar, this study investigates the impact of Pacific Asian researchers and their papers by the citation numbers of their published papers in 21 IS journals. Common keywords and theories adopted in the most cited papers are also examined. The results indicate that scholars in Hong Kong, Australia, and Singapore are major contributors in the region. MIS Quarterly publishes most highly cited papers. Papers co-authored across regions are more likely to create high citations. Our findings provide insights into how research reports from Pacific Asian authors have influenced the development of knowledge in information systems. Available at: https://aisel.aisnet.org/pajais/vol1/iss1/8

Commentary on the Regulation of Viral Proteins in Autophagy Process

The ability to subvert intracellular antiviral defenses is necessary for virus to survive as its replication occurs only in the host cells. Viruses have to modulate cellular processes and antiviral mechanisms to their own advantage during the entire virus life cycle. Autophagy plays important roles in cell regulation. Its function is not only to catabolize aggregate proteins and damaged organelles for recycling but also to serve as innate immunity to remove intracellular pathogenic elements such as viruses. Nevertheless, some viruses have evolved to negatively regulate autophagy by inhibiting its formation. Even more, some viruses have employed autophagy to benefit their replication. To date, there are more and more growing evidences uncovering the functions of many viral proteins to regulate autophagy through different cellular pathways. In this review, we will discuss the relationship between viruses and autophagy and summarize the current knowledge on the functions of viral proteins contributing to affect autophagy process

Earthquake-Resistant Squat Walls Reinforced with High- Strength Steel

Results are reported from reversed cyclic tests of five large-scale squat wall specimens reinforced with steel bars having a specified yield strength of either 60 or 115 ksi (413 or 792 MPa). Two specimens were designed for a shear stress of 5√fc′ psi (0.42√fc′ MPa) and the other three 9√fc′ psi (0.75√fc′ MPa). Boundary element confining reinforcement complied with the requirements of Chapter 18 of ACI 318-14 in all but one specimen, which had 50% of the required transverse boundary element reinforcement. Specimens constructed with Grade 115 steel had similar strength and exhibited 20% greater drift capacity than those with Grade 60 steel. Use of Grade 115 steel tended to control the softening effect of sliding at the base of the wall and to increase the component of drift due to reinforcement strain penetration into the foundation

Erratum to: Architectural Growth of Cu Nanoparticles Through Electrodeposition

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Abdominal Compartment Syndrome

Abdominal compartment syndrome (ACS) is a progressively increasing intraabdominal pressure of more than 20 mm Hg with new-onset thoracoabdominal organ dysfunction. Primary abdominal compartment syndrome means increased pressure due to injury or disease in the abdominopelvic region. Secondary abdominal compartment syndrome means disease originating from outside the abdomen, such as significant burns or sepsis. As the pressure inside the abdomen increases, organ failure occurs, and the kidneys and lungs are the most frequently affected. Managements of ACS are multidisciplinary. Conservative treatment with adequate volume supple and with aggressive hemodynamic support is the first step. Decompressive laparotomy with open abdomen is indicated when ACS is refractory to conservative treatment and complicated with multiple organ failure. ACS can result in a high mortality rate, and successful treatment requires cooperation between physicians, intensivists, and surgeons

Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation.

PKM2 is a key metabolic enzyme central to glucose metabolism and energy expenditure. Multiple stimuli regulate PKM2's activity through allosteric modulation and post-translational modifications. Furthermore, PKM2 can partner with KDM8, an oncogenic demethylase and enter the nucleus to serve as a HIF1α co-activator. Yet, the mechanistic basis of the exon-10 region in allosteric regulation and nuclear translocation remains unclear. Here, we determined the crystal structures and kinetic coupling constants of exon-10 tumor-related mutants (H391Y and R399E), showing altered structural plasticity and reduced allostery. Immunoprecipitation analysis revealed increased interaction with KDM8 for H391Y, R399E, and G415R. We also found a higher degree of HIF1α-mediated transactivation activity, particularly in the presence of KDM8. Furthermore, overexpression of PKM2 mutants significantly elevated cell growth and migration. Together, PKM2 exon-10 mutations lead to structure-allostery alterations and increased nuclear functions mediated by KDM8 in breast cancer cells. Targeting the PKM2-KDM8 complex may provide a potential therapeutic intervention