StoryChat: Designing a Narrative-Based Viewer Participation Tool for Live Streaming Chatrooms

Live streaming platforms and existing viewer participation tools enable users to interact and engage with an online community, but the anonymity and scale of chat usually result in the spread of negative comments. However, only a few existing moderation tools investigate the influence of proactive moderation on viewers' engagement and prosocial behavior. To address this, we developed StoryChat, a narrative-based viewer participation tool that utilizes a dynamic graphical plot to reflect chatroom negativity. We crafted the narrative through a viewer-centered (N=65) iterative design process and evaluated the tool with 48 experienced viewers in a deployment study. We discovered that StoryChat encouraged viewers to contribute prosocial comments, increased viewer engagement, and fostered viewers' sense of community. Viewers reported a closer connection between streamers and other viewers because of the narrative design, suggesting that narrative-based viewer engagement tools have the potential to encourage community engagement and prosocial behaviors

Chain of Natural Language Inference for Reducing Large Language Model Ungrounded Hallucinations

Large language models (LLMs) can generate fluent natural language texts when given relevant documents as background context. This ability has attracted considerable interest in developing industry applications of LLMs. However, LLMs are prone to generate hallucinations that are not supported by the provided sources. In this paper, we propose a hierarchical framework to detect and mitigate such ungrounded hallucination. Our framework uses Chain of Natural Language Inference (CoNLI) for hallucination detection and hallucination reduction via post-editing. Our approach achieves state-of-the-art performance on hallucination detection and enhances text quality through rewrite, using LLMs without any fine-tuning or domain-specific prompt engineering. We show that this simple plug-and-play framework can serve as an effective choice for hallucination detection and reduction, achieving competitive performance across various contexts.Comment: The source code is available at https://github.com/microsoft/CoNLI_hallucinatio

Locally Advanced Oncocytic Carcinoma of the Nasal Cavity Treated With Surgery and Intensity-modulated Radiotherapy

Oncocytic carcinomas of the nasal cavity are extremely rare. We report 1 patient whose primary tumor and neck lymphadenopathies were under control nearly 2 years after combined surgery and radiotherapy. An 80-year-old man with a history of nasal oncocytoma had received excision twice previously. Computed tomography demonstrated locally advanced recurrent tumor invading the paranasal sinuses and orbit with lymphadenopathies in the right neck. Skull base surgery was performed. Pathological examination revealed oncocytic carcinoma. Positron emission tomography showed hypermetabolic lesions in the surgical bed and right neck. The patient subsequently received intensity-modulated radiotherapy to the primary site and the whole neck. Follow-up computed tomography 4 months later showed marked shrinkage of the neck lymphadenopathies. There was no progression after nearly 2 years. Although these tumors have historically been regarded as radioresistant, the combined treatment of surgery followed by radiotherapy may offer the best chance for control of locally advanced disease

Depth-Varying Friction on a Ramp-Flat Fault Illuminated by ∼3-Year InSAR Observations Following the 2017 Mw 7.3 Sarpol-e Zahab Earthquake

We use interferometric synthetic aperture radar observations to investigate the fault geometry and afterslip evolution within 3 years after a mainshock. The postseismic observations favor a ramp-flat structure in which the flat angle should be lower than 10°. The postseismic deformation is dominated by afterslip, while the viscoelastic response is negligible. A multisegment, stress-driven afterslip model (hereafter called the SA-2 model) with depth-varying frictional properties better explains the spatiotemporal evolution of the postseismic deformation than a two-segment, stress-driven afterslip model (hereafter called the SA-1 model). Although the SA-2 model does not improve the misfit significantly, this multisegment fault with depth-varying friction is more physically plausible given the depth-varying mechanical stratigraphy in the region. Compared to the kinematic afterslip model, the mechanical afterslip models with friction variation tend to underestimate early postseismic deformation to the west, which may indicate more complex fault friction than we expected. Both the kinematic and stress-driven models can resolve downdip afterslip, although it could be affected by data noise and model resolution. The transition depth of the sedimentary cover basement interface inferred by afterslip models is ∼12 km in the seismogenic zone, which coincides with the regional stratigraphic profile. Because the coseismic rupture propagated along a basement-involved fault while the postseismic slip may activate the frontal structures and/or shallower detachments in the sedimentary cover, the 2017 Sarpol-e Zahab earthquake may have acted as a typical event that contributed to both thick- and thin-skinned shortening of the Zagros in both seismic and aseismic ways

Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation

<p>Abstract</p> <p>Background</p> <p>Our previous study showed that, in basal cell carcinoma cells, arecoline reduces levels of the tumor cell survival factor interleukin-6 (IL-6), increases levels of tumor suppressor factor p53, and elicits cell cycle arrest, followed by apoptosis. In preliminarily studies, we observed that arecoline induces detachment of the human-derived hepatoma cell line HA22T/VGH from the extracellular matrix. In the present study, we explored the fate of the detached HA22T/VGH cells and investigated the underlying mechanism.</p> <p>Methods</p> <p>HA22T/VGH cells or primary cultured rat hepatocytes were treated with arecoline, then changes in morphology, viability, apoptosis, and the expression of surface β1-integrin, apoptosis-related proteins, and IL-6 were examined. Furthermore, activation of the signal transducer and activator of transcription 3 (STAT3) pathway and the RhoA/Rock signaling pathway, including p190RhoGAP and Src homology-2 domain-containing phosphatase SHP2, was examined.</p> <p>Results</p> <p>A low concentration of arecoline (≤ 100 μg/ml) caused cytoskeletal changes in HA22T/VGH cells, but not hepatocytes, and this was accompanied by decreased β1-integrin expression and followed by apoptosis, indicating that HA22T/VGH cells undergo anoikis after arecoline treatment. IL-6 expression and phosphorylation of STAT3, which provides protection against anoikis, were inhibited and levels of downstream signaling proteins, including Bcl-X_Land Bcl-2, were decreased, while Bax expression, mitochondrial cytochrome c release, and caspase-3 activity were increased. In addition, phosphorylation/activation of p190RhoGAP, a RhoA inhibitor, and of its upstream regulator, SHP2, was inhibited by arecoline treatment, while Rho/Rock activation was increased. Addition of the RhoA inhibitor attenuated the effects of arecoline.</p> <p>Conclusions</p> <p>This study demonstrated that arecoline induces anoikis of HA22T/VGH cells involving inhibition of STAT3 and increased RhoA/Rock activation and that the STAT3 and RhoA/Rock signaling pathways are connected.</p