Performance evaluation on the implementation of Pre-established Medical Processes for nurse practitioners in the hospitals

In 2015, Taiwan announced the establishment of “Pre-established Medical Processes” and related regulations to assist nurse practitioners in the clinical tasks, maintain medical quality and patient safety, and provide protection in clinical practice. However, the effectiveness of implementation still needs to be improved and strengthened. This study adopts the TAM and the TTF as the research framework, and a cross-sectional design. The questionnaires are administered to the professional nurse practitioners in the hospitals of central Taiwan. A total of 300 questionnaires were distributed, and Smart PLS 3.0 and SPSS 24.0 were both applied to verify interpretability. The questionnaire recovery rate was 88.3%, and the overall predictive power was 65.2%. Technological characteristics and TTF had a significant impact on perceived usefulness

Dynamic Finite Element Analysis on Underlay Microstructure of Cu/low-k Wafer during Wirebonding

The aim of present research is to investigate dynamic stress analysis for microstructure of Cu/Low-K wafer subjected to wirebonding predicted by finite element software ANSYS/LS-DYNA. Two major analyses are conducted in the present research. In the first, the characteristic of heat affected zone (HAZ) and free air ball (FAB) on ultra thin Au wire have been carefully experimental measured. Secondary, the dynamic response on Al pad/beneath the pad of Cu/low-K wafer during wirebonding process has been successfully predicted by finite element analysis (FEA). Tensile mechanical properties of ultra thin wire before/after electric flame-off (EFO) process have been investigated by self-design pull test fixture. The experimental obtained hardening value has significantly influence on localize stressed area on Al pad. This would result in Al pad squeezing around the smashed FAB during impact stage and the consequent thermosonic vibration stage. Microstructure of FAB and HAZ are also carefully measured by micro/nano indentation instruments. All the measured data serves as material inputs for the FEA explicit software ANSYS/LS-DYNA. Because the crack of low-k layer and delamination of copper via are observed, dynamic transient analysis is performed to inspect the overall stress/strain distributions on the microstructure of Cu/low-k wafer. Special emphasizes are focused on the copper via layout and optimal design of Cu/low-k microstructure. It is also shown that the Al pad can be replaced by Al-Cu alloy pad or Cu pad to avoid large deformation on pad and cracking beneath the surface. A series of comprehensive experimental works and FEA predictions have been performed to increase bondability and reliability in this study

EmbeddingTree: Hierarchical Exploration of Entity Features in Embedding

Embedding learning transforms discrete data entities into continuous numerical representations, encoding features/properties of the entities. Despite the outstanding performance reported from different embedding learning algorithms, few efforts were devoted to structurally interpreting how features are encoded in the learned embedding space. This work proposes EmbeddingTree, a hierarchical embedding exploration algorithm that relates the semantics of entity features with the less-interpretable embedding vectors. An interactive visualization tool is also developed based on EmbeddingTree to explore high-dimensional embeddings. The tool helps users discover nuance features of data entities, perform feature denoising/injecting in embedding training, and generate embeddings for unseen entities. We demonstrate the efficacy of EmbeddingTree and our visualization tool through embeddings generated for industry-scale merchant data and the public 30Music listening/playlists dataset.Comment: 5 pages, 3 figures, accepted by PacificVis 202

Isolated pancreatic metastasis from rectal cancer: a case report and review of literature

Isolated pancreatic metastases from a non-pancreatic primary malignancy are very rare. Studies have shown that resection of metastases is of proven benefit in some types of tumors. We report a case of 76-year-old Taiwanese woman with rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and abdominoperineal resection 2 years ago presenting with an asymptomatic mass at the pancreatic tail on a routine follow up abdominal computed tomography scan. The patient underwent distal pancreatectomy and splenectomy under the preoperative impression of a primary pancreatic malignancy. Histological examination of the surgical specimen showed metastatic adenocarcinoma. Immunohistochemical studies confirmed the diagnosis of pancreatic metastasis from rectal adenocarcinoma. Postoperative chemotherapy in the form of oral capecitabine was given. The patient is alive and disease free 12 months after the surgery. In a patient presenting with a pancreatic mass with history of a non-pancreatic malignancy, a differential diagnosis of pancreatic metastasis should be considered. Surgical resection of a solitary pancreatic mass is justified not only to get the definitive diagnosis but also to improve the survival

The Arabidopsis Malectin-Like/LRR-RLK IOS1 is Critical for BAK1-Dependent and BAK1-Independent Pattern-Triggered Immunity

Plasma membrane-localized pattern recognition receptors (PRRs) such as FLAGELLIN SENSING2 (FLS2), EF-TU RECEPTOR (EFR) and CHITIN ELICITOR RECEPTOR KINASE 1 (CERK1) recognize microbe-associated molecular patterns (MAMPs) to activate pattern-triggered immunity (PTI). A reverse genetics approach on genes responsive to the priming agent beta-aminobutyric acid (BABA) revealed IMPAIRED OOMYCETE SUSCEPTIBILITY1 (IOS1) as a critical PTI player. Arabidopsis thaliana ios1 mutants were hyper-susceptible to Pseudomonas syringae bacteria. Accordingly, ios1 mutants showed defective PTI responses, notably delayed up-regulation of the PTI-marker gene FLG22-INDUCED RECEPTOR-LIKE KINASE1 (FRK1), reduced callose deposition and mitogen-activated protein kinase activation upon MAMP treatment. Moreover, Arabidopsis lines over-expressing IOS1 were more resistant to bacteria and showed a primed PTI response. In vitro pull-down, bimolecular fluorescence complementation, co-immunoprecipitation, and mass spectrometry analyses supported the existence of complexes between the membrane-localized IOS1 and BRASSINOSTEROID INSENSITIVE1-ASSOCIATED KINASE1 (BAK1)-dependent PRRs FLS2 and EFR, as well as with the BAK1-independent PRR CERK1. IOS1 also associated with BAK1 in a ligand-independent manner, and positively regulated FLS2-BAK1 complex formation upon MAMP treatment. In addition, IOS1 was critical for chitin-mediated PTI. Finally, ios1 mutants were defective in BABA-induced resistance and priming. This work reveals IOS1 as a novel regulatory protein of FLS2-, EFR- and CERK1-mediated signaling pathways that primes PTI activation