Kung Fu Training Improves Physical Fitness Measures in Overweight/Obese Adolescents: The “Martial Fitness” Study

Aim. To examine the efficacy of a six-month Kung Fu (KF) program on physical fitness in overweight/obese adolescents. Methods. Subjects were randomly assigned to the KF or sham exercise (Tai Chi, TC) control group. Physical measurements in cardiovascular fitness and muscle fitness occurred at baseline and after 6 months of training thrice weekly. Results. Twenty subjects were recruited. One subject was lost to follow-up, although overall compliance to the training sessions was 46.7 ± 27.8%. At follow-up, the cohort improved in absolute upper (P = .002) and lower (P = .04) body strength, and upper body muscle endurance (P = .02), without group differences. KF training resulted in significantly greater improvements in submaximal cardiovascular fitness (P = .03), lower body muscle endurance (P = .28; significant 95% CI: 0.37–2.49), and upper body muscle velocity (P = .03) relative to TC training. Conclusions. This short-term KF program improved submaximal cardiovascular fitness, lower body muscle endurance, and muscle velocity, in overweight/obese adolescents with very low baseline fitness

Sleep and Wellbeing, Now and in the Future

The processes of sleeping, eating and moving, in concert with cognition and learning, support health and life [...

Associations among work-related stress, cortisol, inflammation, and metabolic syndrome

This cross-sectional study examined the relationship between work-related stress, cortisol, and C-reactive protein (CRP) in predicting metabolic syndrome (MtS). Self-reported work stress measured by the effort reward imbalance ratio (ERI), anthropometric data, CRP, and saliva cortisol were collected from 204 healthy Jordanian male workers. ERI and cortisol were significantly associated with the presence of MtS (OR = 4.74, 95% CI: 2.13–10.55; OR = 3.03, 95% CI: 2.08–4.40; OR = 11.50, 95% CI: 2.16–59.14, respectively). The odds of MtS in men with high ERI and high cortisol were significantly higher than that of men with low ERI and low cortisol (OR = 11.50, 95% CI: 2.16–59.14). CRP was significantly associated with MtS (OR = 2.51, 95% CI: 1.50–4.20). The odds of MtS were significantly higher in centrally obese men with both high ERI and CRP level. Thus, high ERI along with high cortisol or high CRP increases the risk for MtS, especially among centrally obese men

The validity of Actiwatch2 and SenseWear armband compared against polysomnography at different ambient temperature conditions

There were no validation studies on portable sleep devices under different ambient temperature, thus this study evaluated the validity of wrist Actiwatch2 (AW2) or SenseWear armband (SWA) against polysomnography (PSG) in different ambient temperatures. Nine healthy young participants (6 males, aged 23.3±4.1 y) underwent nine nights of study at ambient temperature of 17 °C, 22 °C and 29 °C in random order, after an adaptation night. They wore the AW2 and SWA while being monitored for PSG simultaneously. A linear mixed model indicated that AW2 is valid for sleep onset latency (SOL), total sleep time (TST) and sleep efficiency (SE) but significantly overestimated wake after sleep onset (WASO) at 17 °C and 22 °C. SWA is valid for WASO, TST and SE at these temperatures, but severely underestimates SOL. However, at 29 °C, SWA significantly overestimated WASO and underestimated TST and SE. Bland–Altman plots showed small biases with acceptable limits of agreement (LoA) for AW2 whereas, small biases and relatively wider LoA for most sleep variables were observed in SWA. The kappa statistic showed a moderate sleep–wake epoch agreement, with a high sensitivity but poor specificity; wake detection remains suboptimal. AW2 showed small biases for most of sleep variables at all temperature conditions, except for WASO. SWA is reliable for measures of TST, WASO and SE at 17–22 °C but not at 29 °C, and SOL approximates that of PSG only at 29 °C, thus caution is needed when monitoring sleep at different temperatures, especially in home sleep studies, in which temperature conditions are more variable

Efficacy of Morning Shorter Wavelength Lighting in the Visible (Blue) Range and Broad-Spectrum or Blue-Enriched Bright White Light in Regulating Sleep, Mood, and Fatigue in Traumatic Brain Injury: A Systematic Review

Traumatic brain injury (TBI) profoundly affects sleep, mood, and fatigue, impeding daily functioning and recovery. This systematic review evaluates the efficacy of morning shorter wavelength lighting in the visible (blue) range and broad-spectrum or blue-enriched bright white light exposure in mitigating these challenges among TBI patients. Through electronic database searches up to May 2023, studies assessing sleep, circadian rhythm, sleepiness, mood, and fatigue outcomes in TBI patients exposed to morning shorter wavelength lighting in the visible (blue) range and broad-spectrum or blue-enriched bright white light were identified. Seven studies involving 309 participants met the inclusion criteria. Results indicated consistent advancement in sleep timing among individuals with mild TBI, alongside improvements in total sleep time, mood, and reduced sleepiness with both types of light exposure, particularly in mild TBI cases. Notably, two studies demonstrated alleviation of fatigue exclusively in severe TBI cases following light exposure. Despite promising findings, evidence remains limited, emphasizing the need for future research with standardized protocols to confirm the potential and optimize the benefits of light therapy for TBI recovery

Role of Tissue and Systemic Hypoxia in Obesity and Type 2 Diabetes

Human lifestyle in most modern and developing societies has dramatically changed over past decades. Physical inactivity along with unrestricted access to calorie dense foods has established an “obesogenic” environment and contributed to a serious epidemic of obesity and type 2 diabetes (T2D), associated with increased morbidity and mortality. In 2005 a population-based study conducted by Reichmuth et al. of University of Wisconsin with a cross-sectional and longitudinal analysis identified that among 1387 participants the odds ratio for T2D with an apnea-hypopnea index (AHI) \u3e 15 versus an AHI \u3c 5 was 2.30 (1.28–4.11; p \u3c 0.01) after adjustment for age, sex, and body habitus. Therefore it has been assumed that intermittent hypoxic periods associated with obstructive sleep apnea (OSA) may play a pathogenic role in inducing insulin resistance and T2D. At organ/tissue levels, in 2007–2009 Ye and colleagues first proposed a central role played by adipose tissue hypoxia resulting from adipocyte expansion in promoting chronic inflammation, adiponectin reduction, adipocyte dysfunction, and death in obese individuals. This group of researchers later identified the mediator roles played by hypoxia inducible factor 1α (HIF-1α) and other hypoxia-triggered signaling mechanisms that may promote free fatty acid release and inhibit glucose uptake in adipocytes by inhibition of the insulin-signaling pathway and induction of cell death

Identification of different types of respiratory neurones in the dorsal brainstem nucleus tractus solitarius of the rat

In Nembutal anaesthetised, spontaneously breathing rats, stereotaxic mapping of the nucleus tractus solitarius (NTS) for respiratory neuronal activity was undertaken. Eight different types of respiratory cells were found between 0.25 and 1.5 mm lateral to midline, extending 0.5 mm caudal to 1.5 mm rostral to obex, and 0.4-1.5 mm below the dorsal surface. A study of the respiratory motor (diaphragm EMG) and neuronal responses to excitatory amino acid (EAA) stimulation of the NTS areas was undertaken. Electrical stimulation of the vagus nerve was employed to study the NTS cellular responses to activation of pulmonary afferents. The effects of chemical activation of the midbrain periaqueductal grey (PAG) on NTS respiratory neuronal activity were investigated. EAA microinjections into the ventrolateral NTS rostral to the obex resulted in an increase in respiratory motor frequency along with increases to inspiratory cell discharge, whilst microinjections into the medial NTS caudal to the obex caused respiratory depression. EAA stimulation of calamus scriptorius produced apnea. NTS inspiratory neurones were inhibited following stimulation of ipsilateral vagus nerve, suggesting their involvement in the Hering-Breuer reflex pathway. PAG stimulation caused excitation of the NTS inspiratory cells indicating the presence of an excitatory respiratory pathway between the two nuclei. Following β-adrenergic antagonist pre-treatment of ventrolateral NTS, EAA microinjections into PAG did not evoke a cardiorespiratory effect. Based on the various findings the role of NTS in organising respiration in the rat is discussed

Clinical Patterns of Obstructive Sleep Apnea and Its Comorbid Conditions: A Data Mining Approach

OBJECTIVES: Obstructive sleep apnea often results in a wide range of comorbid conditions. Although some conditions have been clearly identified as comorbid, a full clinical pattern of associated diseases has not been systematically documented. This research aimed to reveal the full pattern of comorbid conditions associated with OSA by employing a data mining technique. METHODS: A large data repository (the New South Wales inpatient Data Collection) collected between 1999 and 2004 was mined, and all clinical diagnoses were coded with ICD-10-AM codes. RESULTS: A total of 60,197 cases (4% of total records) were identified as related to OSA (72.2% males, 27.8% females). OSA occurrence showed 2 peaks at 0-4 years and 55-59 years. A strikingly low occurrence was observed for the adolescent years. Conditions comorbid with OSA in adults by descending frequency were essential hypertension, obesity, hypercholesterolemia, type 2 diabetes, past or current tobacco use, and ischemic heart conditions. Obesity and OSA showed a similar time course of onset, with a latent period of 5 years for hypertension and type 2 diabetes and 15 years for chronic ischemic heart conditions. Comorbid conditions were predominantly of the cardiovascular, endocrine/metabolic and respiratory systems. The data also indicated OSA patients are high users of health services. CONCLUSIONS: The data mining technique confirms the prevalence of the disease, describes the age distribution patterns and time courses of disease development from obesity and OSAto comorbid conditions, and implicates possible interrelationships among these conditions and high cost of treating OSA patients

The association between work stress and inflammatory biomarkers in Jordanian male workers

The study aimed to establish the association of work stress, expressed as effort-reward imbalance (ERI), and C-reactive protein (CRP) in 152 healthy Jordanian male employees. Self-report work stress, anthropometric data, and blood for CRP analysis were collected. A significant correlation between ERI and CRP (r = 0.29, p  <  .01), and between waist circumference with CRP (r = 0.44, p  <  .01) was found. Central obesity explained most of the variance in CRP after controlling for various covariates, and ERI was not a significant predictor of CRP (ΔR2 = 0.02; β = 0.15, p = .052). However, when only the centrally obese group was considered, ERI accounted for 5.0% of the variability in the CRP (β = 0.24, p  <  .05). Results of this study confirm previous findings that obesity is significantly associated with CRP, and support the notion that higher ERI amongst obese workers is one small but significant predictor of increased levels of CRP

Does the Proximity of Meals to Bedtime Influence the Sleep of Young Adults? A Cross-Sectional Survey of University Students

Avoiding food before bedtime is a widely accepted sleep hygiene practice, yet few studies have assessed meal timing as a risk factor for disrupted sleep. This study examined the relationship between evening meal timing and sleep quality in young adults. A total of N = 793 participants (26% male) aged between 18 and 29 years responded to an online survey, which captured sociodemographic information, lifestyle variables, and sleep characteristics. Meal timing was defined as meals more than 3 h before or within 3 h of bedtime. The outcomes were as follows: one or more nocturnal awakenings, sleep onset latency of &gt;30 min, and sleep duration of &le;6 h. Logistic regression analyses showed that eating within 3 h of bedtime was positively associated with nocturnal awakening (OR = 1.61, 95% CI = 1.15&ndash;2.27) but not long sleep onset latency (1.24; 0.89&ndash;1.73) or short sleep duration (0.79; 0.49&ndash;1.26). The relationship remained significant after adjusting for potential confounders of ethnicity and body mass index (OR = 1.43, 95% CI = 1.00&ndash;2.04). Meal timing appears to be a modifiable risk factor for nocturnal awakenings and disrupted sleep. However, this is a preliminary cross-sectional study and highlights the need for additional research on the influence of the timing of food intake on sleep