Spectral Analysis for Semantic Segmentation with Applications on Feature Truncation and Weak Annotation

We propose spectral analysis to investigate the correlation between the accuracy and the resolution of segmentation maps for semantic segmentation. The current networks predict segmentation maps on the down-sampled grid of images to alleviate the computational cost. Moreover, these networks can be trained by weak annotations that utilize only the coarse contour of segmentation maps. Despite the successful achievement of these works utilizing the low-frequency information of segmentation maps, however, the accuracy of resultant segmentation maps may also be degraded in the regions near object boundaries. It is yet unclear for a theoretical guideline to determine an optimal down-sampled grid to strike the balance between the cost and the accuracy of segmentation. We analyze the objective function (cross-entropy) and network back-propagation process in frequency domain. We discover that cross-entropy and key features of CNN are mainly contributed by the low-frequency components of segmentation maps. This further provides us quantitative results to determine the efficacy of down-sampled grid of segmentation maps. The analysis is then validated on the two applications: the feature truncation method and the block-wise annotation that limit the high-frequency components of the CNN features and annotation, respectively. The results agree with our analysis. Thus the success of the existing work utilizing low-frequency information of segmentation maps now has theoretical foundation.Comment: 21 page

Controlled Morphological Structure of Ceria Nanoparticles Prepared by Spray Pyrolysis

AbstractCeria based materials have been widely used as catalyst supporters and electrolytes. Different applications require different morphologies, and the microstructural control during the synthesis is crucial. In the study, ceria particles were prepared from various precursors using a spray pyrolysis (SP). Comparing to the hollow and porous particles, the formation mechanism with solid spherical structure is not clarified readily. The ceria particles were characterized by transmission electron microscopy, thermogravimetry analysis and X-ray photoelectron spectroscopy. This experimental result suggests that the morphology is controlled by the precursors and could be related to their decomposed behavior during the heating process in SP

Predicting adverse side effects of drugs

<p>Abstract</p> <p>Background</p> <p>Studies of toxicity and unintended side effects can lead to improved drug safety and efficacy. One promising form of study comes from molecular systems biology in the form of "systems pharmacology". Systems pharmacology combines data from clinical observation and molecular biology. This approach is new, however, and there are few examples of how it can practically predict adverse reactions (ADRs) from an experimental drug with acceptable accuracy.</p> <p>Results</p> <p>We have developed a new and practical computational framework to accurately predict ADRs of trial drugs. We combine clinical observation data with drug target data, protein-protein interaction (PPI) networks, and gene ontology (GO) annotations. We use cardiotoxicity, one of the major causes for drug withdrawals, as a case study to demonstrate the power of the framework. Our results show that an <it>in silico </it>model built on this framework can achieve a satisfactory cardiotoxicity ADR prediction performance (median AUC = 0.771, Accuracy = 0.675, Sensitivity = 0.632, and Specificity = 0.789). Our results also demonstrate the significance of incorporating prior knowledge, including gene networks and gene annotations, to improve future ADR assessments.</p> <p>Conclusions</p> <p>Biomolecular network and gene annotation information can significantly improve the predictive accuracy of ADR of drugs under development. The use of PPI networks can increase prediction specificity and the use of GO annotations can increase prediction sensitivity. Using cardiotoxicity as an example, we are able to further identify cardiotoxicity-related proteins among drug target expanding PPI networks. The systems pharmacology approach that we developed in this study can be generally applicable to all future developmental drug ADR assessments and predictions.</p