3 research outputs found
Anti-inflammatory and Analgesic Effects of Aqueous Extract of Aloe Vera ( Aloe barbadensis ) in Rats
The anti-inflammatory and analgesic activities of aqueous extract of
Aloe barbadensis was investigated in rats. Formalin- induced hind paw
oedema was used to assess the anti- inflammatory activity of the
extract while acetic acid-induced abdominal writhing was used for
analgesic activity. The results of the anti-inflammatory study revealed
that 25, 50 and 100 mg/kg of the extract reduced the formalin-induced
oedema significantly (P <0.05) at the beginning of 3 hours when
compared to the control group. In the analgesic study, 25, 50 and 100
mg/kg of extract significantly (P <0.5) reduced the number of
writhes induced by a 0.6% Acetic acid solution with an approximately
66.49%, 57.59% and 68.06% inhibition respectively. The present study
showed that the aqueous extract of Aloe barbadensis has
anti-inflammatory and analgesic activities that could be mediated via
modulators of pain and inflammation or through central activity