9 research outputs found
Modelling of the 3D structure of IFN–alpha–k, characterization of its surface molecular properties and preliminary evaluation of its interactions with beta-cyclodextrin derivatives
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Modelling of the 3-D structure of human interferon a-k and characterization of its surface molecular properties
No full textUbidecarenone nanoemulsified composite systems
No full textThe nanoemulsified composite (NEC(TM)) delivery system is a patented technology based on the incorporation of a double microemulsion into microporous carrier. This approach was applied on the very water insoluble ubidecarenone drug. The resulting composite powder showed good technological properties such as flowability; also good stability was evidentiated, with size of the nano-droplets released from the systems maintained equal to the starting size also after a long storage. Furthermore very good biopharmaceutical properties were originated, with water solubility concentrations up to 50-fold higher than pure ubidecarenone and oral absorption in rats up to three-fold greater than standard commercial products in terms of plasma levels and AUC. (C) 2004 Elsevier B.V. All rights reserved
Microparticles based on hybrid polymeric materials for controlled release of biologically active molecules. A process for preparing the same and their uses for in vivo and in vitro therapy, prophylaxis and diagnostics
No full textDevelopment of Cyclosporine-A in nanoemulsified composites (NECTM)
No full textFormulation and characterization approach of cyclospirin-A in nanoemulsified composites
Solid double microemulsions for improved absorption of scarcely bioavailable drugs
No full textSolid double microemulsions for improved absorption of scarcely bioavailable drug
