Il progetto Interreg Italia-Slovenia HARMO-DATA: un geoportale per la condivisione di dati territoriali transfrontalieri armonizzati

Il progetto Interreg HARMO-DATA, finanziato nell’ambito del Programma Interreg V-A Italia-Slovenia 2014-2020, è stato avviato ufficialmente a Settembre 2017 e si è concluso il 30 giugno 2019. Il Partenariato era composto da: Geodetski In titut Slovenije, Ljubljana, Slovenia (coordinamento), Geodetska Uprava Republike Slovenije, Igea S.r.l. Ljubljana, Slovenia, Insiel S.p.a. Trieste, GeoSNav Lab - Dipartimento di Ingegneria e Architettura, Università degli Studi di Trieste - Terre S.r.l. Mestre. Hanno partecipato inoltre in qualità di partner associati: Regione Veneto, Regione Friuli Venezia Giulia e Ministero sloveno per l’ambiente ed il territorio. Obiettivo generale del Progetto è stato quello di rafforzare la capacità di cooperazione istituzionale transfrontaliera tra le autorità pubbliche e i responsabili della pianificazione territoriale, promuovendo la creazione di soluzioni condivise per il coordinamento e un’efficace gestione del territorio

Circadian variations in cyclosporine C2 concentrations during the first 2 weeks after liver transplantation.

The strategies currently used to monitor concentrations of cyclosporine (CsA) in trans- planted patients include whole blood trough (C0), total or abbreviated area under the curve (AUC) concentration and population pharmacokinetic approaches. Recently, a single blood concentration measurement at 2 hours (C2) after CsA administration has been shown to be helpful to predict clinical effects during the first weeks after transplan- tation of liver and kidney grafts. However, this approach has raised multiple questions about pharmacokinetic variability, analytical methods, and organizational requirements. From a pharmacokinetic point of view, the variability of CsA blood concentrations may relate to circadian variations. The present study sought to characterize the circadian variation in C0 and C2 CsA levels among 20 liver transplant recipients during the first 2 weeks posttransplant. All patients received two equal oral doses of CsA microemulsion formulation every 12 hours. Blood samples were collected before and 2 hours after CsA administration in the morning (AM) and in the evening (PM). Whole blood concentrations of CsA were assayed using the monoclonal fluorescence polarization immunoassay system. During the first 2 weeks posttransplant, C2 AM mean levels were significantly higher than C2 PM levels (542 241 vs 383 182 ng/mL, P .005), while the C0 AM mean level was not statistically different from the C0 PM (285 174 vs 223 124 ng/mL, P .367). Our results suggest that morning CsA blood samples may afford a better approach to optimize the CsA dosage, especially based on C2 values

Continuous and intermittent cardiac output measurement in hyperdynamic condition: pulmonary artery catheter vs. lithium dilution technique.

National Institutes of Health Search termSearch database All DatabasesPubMedProteinNucleotideGSSESTStructureGenomeBioProjectBioSampleBioSystemsBooksConserved DomainsClonedbGaPdbVarEpigenomicsGeneGEO DataSetsGEO ProfilesHomoloGeneMeSHNCBI Web SiteNLM CatalogOMIAOMIMPMCPopSetProbeProtein ClustersPubChem BioAssayPubChem CompoundPubChem SubstancePubMed HealthSNPSRATaxonomyToolKitToolKitAllUniGeneUniSTS SearchAdvanced Help Result Filters Display Settings: Abstract Send to: Intensive Care Med. 2008 Feb;34(2):257-63. Epub 2007 Oct 6. Continuous and intermittent cardiac output measurement in hyperdynamic conditions: pulmonary artery catheter vs. lithium dilution technique. Costa MG, Della Rocca G, Chiarandini P, Mattelig S, Pompei L, Barriga MS, Reynolds T, Cecconi M, Pietropaoli P. Source Azienda Ospedaliero Universitaria di Udine, Clinica di Anestesia e Rianimazione, P.le S.M. della Misericordia 15, 33100 Udine, Italy. [email protected] Abstract OBJECTIVE: This study aimed to assess the level of agreement of both intermittent cardiac output monitoring by the lithium dilution technique (CO(Li)) and continuous cardiac output monitoring (PulseCO(Li)) using the arterial pressure waveform with intermittent thermodilution using a pulmonary artery catheter (CO(PAC)). DESIGN: Prospective, single-center evaluation. SETTING: University Hospital Intensive Care Unit. PATIENTS: Patients (n=23) receiving liver transplantation. INTERVENTION: Pulmonary artery catheters were placed in all patients and CO(PAC) was determined using thermodilution. CO(Li) and PulseCO(Li) measurements were made using the LiDCO system. MEASUREMENTS AND MAIN RESULTS: Data were collected after intensive care unit admission and every 8h until the 48th hour. A total of 151 CO(PAC), CO(Li) and PulseCO(Li) measurements were analysed. Bias and 95% limit of agreement were 0.11lmin(-1) and -1.84 to + 2.05 lmin(-1) for CO(PAC) vs. CO(Li) (r=0.88) resulting in an overall percentage error of 15.6%. Bias and 95% limit of agreement for CO(PAC) vs. PulseCO(Li) were 0.29 lmin(-1) and -1.87 to + 2.46 lmin(-1) (r=0.85) with a percentage error of 16.8%. Subgroup analysis revealed a percentage error of 15.7% for CO(PAC) vs. CO(Li) and 15.1% for CO(PAC) vs. PulseCO(Li) for data pairs less than 8 lmin(-1), and percentage errors of 15.5% and 18.5% respectively for data pairs higher than 8 lmin(-1). CONCLUSION: In patients with hyperdynamic circulation, intermittent and continuous CO values determined using the LiDCO system showed good agreement with those obtained by intermittent pulmonary artery thermodilution. PMID: 17922106 [PubMed - indexed for MEDLINE