4 research outputs found
Delayed metastatic hemangiopericytoma to the spine from intracranial meningeal primary lesion case report and review of the literature.
No full textHigh grade gliomas and chemotherapy: temozolomide as first line therapy versus administration at recurrence
No full textEDG3 and SHC3 on chromosome 9q22 are co-amplified in human ependymomas
No full textBy qPCR we found that EDG3 and SHC3 were amplified in 60% of ependymomas but none in choroid plexus papillomas. In ependymomas EDG3 and SHC3 amplification increased Shc3 protein levels while EDG3 was less affected. Both proteins were co-immunoprecipitated from ependymoma and Shc3 was tyrosine phosphorylated thus presumably active. We showed by digestion with N-glycosidase-F that EDG3 was glycosylated indicating that EDG3 protein was not retained in the endoplasmic reticulum. The co-immunoprecipitation of Shc3 and EDG3 proteins from ependymomas with amplification of SHC3 and EDG3 genes suggests that the two proteins co-operate and are important for ependymomas in vivo
