Enantioselective Synthesis of Spiro[indolizidine-1,3′-oxindoles]

A three-step procedure for the enantioselective synthesis of spiro­[indolizidine-1,3′-oxindoles], consisting of a stereoselective cyclocondensation reaction between (<i>S</i>)-tryptophanol and a prochiral or racemic δ-oxoester, bromination of the resulting oxazolopiperidone lactam, and a final stereoselective spirocyclization, is reported

Enantioselective Synthesis of Spiro[indolizidine-1,3\u2032-oxindoles]

A three-step procedure for the enantioselective synthesis of spiro[indolizidine-1,3'-oxindoles], consisting of a stereoselective cyclocondensation reaction between (S)-tryptophanol and a prochiral or racemic 5-oxoester, bromination of the resulting oxazolopiperidone lactam, and a final stereoselective spirocyclization, is reported