Completing College: A National View of Student Attainment Rates

College completion, earning a degree or certificate, is considered to be a key college success outcome, supported by every educational policymaker. Yet, institutions and policymakers in the U.S. know surprisingly little about the rates of completion for students who follow all but the most traditional of postsecondary pathways. This is because traditional graduation rate calculations are institution based and only count students who finish at the same institution where they started. Building on findings from previous reports in the National Student Clearinghouse Research Center's Signature Report series, this new report measures this key college success outcome -- rates of first completion -- encompassing postsecondary credentials of all levels and types at any institution in any state, whether it is the first, second, third, or more, attended.Students in the U.S. pursuing a postsecondary education move along pathways that are increasingly complex. In its second Signature Report, Transfer and Mobility: A National View of Pre-Degree Student Movement in Postsecondary Institutions (Hossler et al., 2012), the National Student Clearinghouse Research Center found that one-third of first-time college students attended multiple institutions before earning a degree or certificate. Nontraditional students, like those who postpone college enrollment after high school, attend college part time, and/or have full-time jobs, have become the new majority among U.S. college students. This emphasizes the limitations of continuing to rely on traditional measures of student and institutional success that describe only first-time full-time students who never enroll at any institution other than their starting institution. Such measures fail to capture the full range of outcomes among today's college students. They also fail to recognize institutional and policy efforts to support students pursuing diverse pathways.This report draws on the Clearinghouse database's near-census national coverage of enrollments and awarded degrees to explore the six-year outcomes of a cohort of first-time-in-college degree-seeking students who started in fall 2006 (N=1,878,484)

Location – Positioning Tregs to the right place at the right time

After a fruitless pursuit for suppressor cells spanning 1970s to mid-80s, the identification of CD4+CD25+ T cellsas a specific T-cell lineage with immune regulatory function in the 1990s has revived the theory of active immune tolerance and uncovered a brand-new avenue for immunologic research. Tregs have been shown to play a crucial role both in health and diseases. Whilst tremendous advance has been made in our understanding of the expanding varieties of effector mechanisms exploited by Tregs, the migration phenotypes as well as the anatomic sites where Tregs exert immune regulation are scarcely investigated. Migration of Tregs to either the lymph nodes or peripheral tissues has been shown to be exclusively indispensable in Treg-mediated immune regulation in a variety of experimental models with specific gene-targeted mice. The once seemingly paradoxical findings are partly reconciled by later discovery of various Treg subsets with distinct migration/homing property as well as the inflammatory stage when Tregs come into play along an immune reaction. In our recent study, we investigated the migration characteristics of Treg cells by using the endothelial cell-based shear-stress flow assay that resembles the intravascular blood flow system. We found that both FoxP3-expressing Tregs and anergic T cells generated by blockage of costimulation factors, CD80 and CD86, exhibited a significantly decreased adhesion to endothelial cells as compared to antigen-activated effector T cells (66~88 % reduction). The less migration phenotype hinted inefficient tissue trafficking of the Tregs and suggested the lymph nodes as the anatomic site where Tregs optimally exerted immune regulation. To this speculation, an essential role of Treg lymph node positioning in exerting immune suppression was demonstrated by the inability of adoptively transferred Tregs to prevent footpad inflammation after blockage of lymph node entry of these Tregs by CCR7 or CD62L Ab. Therapeutic modality targeting leukocyte migration has been a mainstay alternative for immunologic diseases. Important messages have arisen for treatments of this kind and Treg-based cell therapy that whilst inflammatory response can be harnessed by modulating the migration property of leukocytes, the relationship between Treg migration phenotypes and their immune regulatory function should always be taken into consideration

GeoLM: Empowering Language Models for Geospatially Grounded Language Understanding

Humans subconsciously engage in geospatial reasoning when reading articles. We recognize place names and their spatial relations in text and mentally associate them with their physical locations on Earth. Although pretrained language models can mimic this cognitive process using linguistic context, they do not utilize valuable geospatial information in large, widely available geographical databases, e.g., OpenStreetMap. This paper introduces GeoLM, a geospatially grounded language model that enhances the understanding of geo-entities in natural language. GeoLM leverages geo-entity mentions as anchors to connect linguistic information in text corpora with geospatial information extracted from geographical databases. GeoLM connects the two types of context through contrastive learning and masked language modeling. It also incorporates a spatial coordinate embedding mechanism to encode distance and direction relations to capture geospatial context. In the experiment, we demonstrate that GeoLM exhibits promising capabilities in supporting toponym recognition, toponym linking, relation extraction, and geo-entity typing, which bridge the gap between natural language processing and geospatial sciences. The code is publicly available at https://github.com/knowledge-computing/geolm.Comment: Accepted to EMNLP23 mai

Did the S.A.R.S. epidemic weaken the integration of Asian stock markets? Evidence from smooth time-varying cointegration analysis

The purpose of this study is to examine the effect of the Severe Acute Respiratory Syndrome (S.A.R.S.) epidemic on the long-run relationship between China and four Asian stock markets. To this end, we first employ the advanced smooth time-varying cointegration model to investigate the existence of a time-varying cointegration relation among these markets and then employ the difference-indifferences approach to analyse whether or not the S.A.R.S. epidemic impacted the long-run relation between China and these four markets during the period 1998–2008, covering 5 years before and after the S.A.R.S. outbreak. Our results support the existence of a time-varying cointegration relation in the aggregate stock price indices, and that the S.A.R.S. epidemic did weaken the long-run relationship between China and the four markets. Therefore, stockholders and policy makers should be concerned about the influence of catastrophic epidemic diseases on the financial integration of stock market in Asia