114 research outputs found
Corrections to Chiral Dynamics of Heavy Hadrons: (I) 1/M Correction
In earlier publications we have analyzed the strong and radiative decays of
heavy hadrons in a formalism which incorporates both heavy-quark and chiral
symmetries. In particular, we have derived a heavy-hadron chiral Lagrangian
whose coupling constants are related by the heavy-quark flavor-spin symmetry
arising from the QCD Lagrangian with infinitely massive quarks. In this paper,
we re-examine the structure of the above chiral Lagrangian by including the
effects of corrections in the heavy quark effective theory. The
relations among the coupling constants, originally derived in the heavy-quark
limit, are modified by heavy quark symmetry breaking interactions in QCD. Some
of the implications are discussed.Comment: PHYZZX, 45 pages, 1 figure (not included), CLNS 93/1192,
IP-ASTP-02-93, ITP-SB-93-0
Probing flavor changing interactions in photon-photon collisions
We examine the subprocess at
electron-positron colliders in the two-Higgs-doublet model with flavor-changing
scalar couplings, where all the one-loop contribuions are considered, and the
results are applicable to the whole mass range of the weakly coupled Higgs
bosons. Because of the heavy top quark mass, this process is important in
probing the flavor-changing top-charm-scalar vertex and could be detectable at
the Next Linear Collider, if the values of the parameters are favorable. The
results show that this process is more promising than the direct
process for discovering flavor changing scalar interactions.Comment: 22 pages, LaTeX, including 5 figures in eps file
Top-Charm Associated Production in High Energy Collisions
The possibility of exploring the flavor changing neutral current
couplings in the production vertex for the reaction \epem\to
t\bar c + \bar tc is examined. Using a model independent parameterization for
the effective Lagrangian to describe the most general three-point interactions,
production cross sections are found to be relatively small at LEP II, but
potentially sizeable at higher energy \epem colliders. The kinematic
characteristics of the signal are studied and a set of cuts are devised for
clean separation of the signal from background. The resulting sensitivity to
anomalous flavor changing couplings at LEP II with an integrated luminosity of
pb is found to be comparable to their present indirect
constraints from loop processes, while at higher energy colliders with
TeV center-of-mass energy and 50-200 fb luminosity, one expects to reach
a sensitivity at or below the percentage level.Comment: Latex, 22 page
Resumming the color-octet contribution to e+ e- -> J/psi + X
Recent observations of the spectrum of J/psi produced in e+ e- collisions at
the Upsilon(4S) resonance are in conflict with fixed-order calculations using
the Non-Relativistic QCD (NRQCD) effective field theory. One problem is that
leading order color-octet mechanisms predict an enhancement of the cross
section for J/psi with maximal energy that is not observed in the data.
However, in this region of phase space large perturbative corrections (Sudakov
logarithms) as well as enhanced nonperturbative effects are important. In this
paper we use the newly developed Soft-Collinear Effective Theory (SCET) to
systematically include these effects. We find that these corrections
significantly broaden the color-octet contribution to the J/psi spectrum. Our
calculation employs a one-stage renormalization group evolution rather than the
two-stage evolution used in previous SCET calculations. We give a simple
argument for why the two methods yield identical results to lowest order in the
SCET power counting.Comment: 27 pages, 7 figure
B Physics at the Tevatron: Run II and Beyond
This report provides a comprehensive overview of the prospects for B physics
at the Tevatron. The work was carried out during a series of workshops starting
in September 1999. There were four working groups: 1) CP Violation, 2) Rare and
Semileptonic Decays, 3) Mixing and Lifetimes, 4) Production, Fragmentation and
Spectroscopy. The report also includes introductory chapters on theoretical and
experimental tools emphasizing aspects of B physics specific to hadron
colliders, as well as overviews of the CDF, D0, and BTeV detectors, and a
Summary.Comment: 583 pages. Further information on the workshops, including
transparencies, can be found at the workshop's homepage:
http://www-theory.lbl.gov/Brun2/. The report is also available in 2-up
http://www-theory.lbl.gov/Brun2/report/report2.ps.gz or chapter-by-chapter
http://www-theory.lbl.gov/Brun2/report
Comparison of two recombinant erythropoietin formulations in patients with anemia due to end-stage renal disease on hemodialysis: A parallel, randomized, double blind study
BACKGROUND: Recombinant human erythropoietin (EPO) is used for the treatment of last stage renal anemia. A new EPO preparation was obtained in Cuba in order to make this treatment fully nationally available. The aim of this study was to compare the pharmacokinetic, pharmacodynamic and safety properties of two recombinant EPO formulations in patients with anemia due to end-stage renal disease on hemodialysis. METHODS: A parallel, randomized, double blind study was performed. A single 100 IU/Kg EPO dose was administered subcutaneously. Heberitro (Heber Biotec, Havana, formulation A), a newly developed product and Eprex (CILAG AG, Switzerland, formulation B), as reference treatment were compared. Thirty-four patients with anemia due to end-stage renal disease on hemodialysis were included. Patients had not received EPO previously. Serum EPO level was measured by enzyme immunoassay (EIA) during 120 hours after administration. Clinical and laboratory variables were determined as pharmacodynamic and safety criteria until 216 hours. RESULTS: Both groups of patients were similar regarding all demographic and baseline characteristics. EPO kinetics profiles were similar for both formulations; the pharmacokinetic parameters were very close (i.e., AUC: 4667 vs. 4918 mIU.h/mL; Cmax: 119.1 vs. 119.7 mIU/mL; Tmax: 13.9 vs. 18.1 h; half-life, 20.0 vs. 22.5 h for formulations A and B, respectively). The 90% confidence intervals for the ratio between both products regarding these metrics were close to the 0.8 â 1.25 range, considered necessary for bioequivalence. Differences did not reach 20% in any case and were not determined by a formulation effect, but probably by a patients' variability effect. Concerning pharmacodynamic features, a high similitude in reticulocyte counts increments until 216 hours and the percentage decrease in serum iron until 120 hours was observed. There were no differences between formulations regarding the adverse events and their intensity. The more frequent events were pain at injection site (35.3%) and hypertension (29%). Additionally, further treatment of the patients with the study product yielded satisfactory increases in hemoglobin and hematocrit values. CONCLUSION: The formulations are comparable. The newly developed product should be acceptable for long-term application
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