1,285 research outputs found
Migrating functionality from ROMs to embedded multipliers
Published versio
Downregulation of the Gli Transcription Factors Regulator Kif7 Facilitates Cell Survival and Migration of Choriocarcinoma Cells
published_or_final_versio
AMPK Activators Suppress Cervical Cancer Cell Growth through Inhibition of DVL3 Mediated Wnt/β-Catenin Signaling Activity
published_or_final_versio
AMPK Activators Suppress Cervical Cancer Cell Growth through Inhibition of DVL3 Mediated Wnt/β-Catenin Signaling Activity
published_or_final_versio
Integrated human papillomavirus analysis as an adjunct for triage of atypical cervical cytology
published_or_final_versio
Overexpression of Forkhead Box Protein M1 (FOXM1) in Ovarian Cancer Correlates with Poor Patient Survival and Contributes to Paclitaxel Resistance
published_or_final_versio
On-shell Recursion in String Theory
We prove that all open string theory disc amplitudes in a flat background
obey Britto-Cachazo-Feng-Witten (BCFW) on-shell recursion relations, up to a
possible reality condition on a kinematic invariant. Arguments that the same
holds for tree level closed string amplitudes are given as well. Non-adjacent
BCFW-shifts are related to adjacent shifts through monodromy relations for
which we provide a novel CFT based derivation. All possible recursion relations
are related by old-fashioned string duality. The field theory limit of the
analysis for amplitudes involving gluons is explicitly shown to be smooth for
both the bosonic string as well as the superstring. In addition to a proof a
less rigorous but more powerful argument based on the underlying CFT is
presented which suggests that the technique may extend to a much more general
setting in string theory. This is illustrated by a discussion of the open
string in a constant B-field background and the closed string on the level of
the sphere.Comment: 36 + 9 pages text, one figure, v3: added discussion on relation to
old-fashioned factorization, typos corrected, published versio
Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers
<p>Abstract</p> <p>Background</p> <p>FBI-1 (factor that binds to the inducer of short transcripts of human immunodeficiency virus-1) is a member of the POK (POZ and Kruppel) family of transcription factors and play important roles in cellular differentiation and oncogenesis. Recent evidence suggests that FBI-1 is expressed at high levels in a subset of human lymphomas and some epithelial solid tumors. However, the function of FBI-1 in human ovarian cancers remains elusive.</p> <p>Results</p> <p>In this study, we investigated the role of FBI-1 in human ovarian cancers, in particularly, its function in cancer cell invasion via modulating membrane type 1-matrix metalloproteinase (MT1-MMP). Significantly higher FBI-1 protein and mRNA expression levels were demonstrated in ovarian cancers samples and cell lines compared with borderline tumors and benign cystadenomas. Increased FBI-1 mRNA expression was correlated significantly with gene amplification (P = 0.037). Moreover, higher FBI-1 expression was found in metastatic foci (P = 0.036) and malignant ascites (P = 0.021), and was significantly associated with advanced stage (P = 0.012), shorter overall survival (P = 0.032) and disease-free survival (P = 0.016). <it>In vitro</it>, overexpressed FBI-1 significantly enhanced cell migration and invasion both in OVCA 420 and SKOV-3 ovarian carcinoma cells, irrespective of <it>p53 </it>status, accompanied with elevated expression of MT1-MMP, but not MMP-2 or TIMP-2. Moreover, knockdown of MT1-MMP abolished FBI-1-mediated cell migration and invasion. Conversely, stable knockdown of FBI-1 remarkably reduced the motility of these cells with decreased expression of MT1-MMP. Promoter assay and chromatin immunoprecipitation study indicated that FBI-1 could directly interact with the promoter spanning ~600bp of the 5'-flanking sequence of MT1-MMP and enhanced its expression in a dose-dependent manner. Furthermore, stable knockdown and ectopic expression of FBI-1 decreased and increased cell proliferation respectively in OVCA 420, but not in the p53 null SKOV-3 cells.</p> <p>Conclusions</p> <p>Our results suggested an important role of FBI-1 in ovarian cancer cell proliferation, cell mobility, and invasiveness, and that FBI-1 can be a potential target of chemotherapy.</p
On correlation functions of Wilson loops, local and non-local operators
We discuss and extend recent conjectures relating partial null limits of
correlation functions of local gauge invariant operators and the expectation
value of null polygonal Wilson loops and local gauge invariant operators. We
point out that a particular partial null limit provides a strategy for the
calculation of the anomalous dimension of short twist-two operators at weak and
strong coupling.Comment: 29 pages, 8 figure
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