Saraca indica

Medicinal plants are used as a complementary and alternative medicine in treatment of various diseases including cancer worldwide, because of their ease of accessibility and cost effectiveness. Multicomposed mixture of compounds present in a plant extract has synergistic activity, increases the therapeutic potential many folds, compensates toxicity, and increases bioavailability. Saraca indica (family Caesalpiniaceae) is one of the most ancient sacred plants with medicinal properties, exhibiting a number of pharmacological effects. Antioxidant, antibreast cancer activity and toxicological evaluation of Saraca indica bark extract (SIE) were carried out in the present study. The results of the study indicated that this herbal preparation has antioxidant and antibreast cancer activity. Toxicological studies suggest that SIE is safer to use and may have a potential to be used as complementary and alternative medicine for breast cancer therapy

Alcoholic Extract of Eclipta alba

As per WHO estimates, 80% of people around the world use medicinal plants for the cure and prevention of various diseases including cancer owing to their easy availability and cost effectiveness. Eclipta alba has long been used in Ayurveda to treat liver diseases, eye ailments, and hair related disorders. The promising medicinal value of E. alba prompted us to study the antioxidant, nontoxic, and anticancer potential of its alcoholic extract. In the current study, we evaluated the in vitro cytotoxic and antioxidant effect of the alcoholic extract of Eclipta alba (AEEA) in multiple cancer cell lines along with control. We have also evaluated its effect on different in vivo toxicity parameters. Here, we found that AEEA was found to be most active in most of the cancer cell lines but it significantly induced apoptosis in human breast cancer cell lines by disrupting mitochondrial membrane potential and DNA damage. Moreover, AEEA treatment inhibited migration in both MCF 7 and MDA-MB-231 cells in a dose dependent manner. Further, AEEA possesses robust in vitro antioxidant activity along with high total phenolic and flavonoid contents. In summary, our results indicate that Eclipta alba has enormous potential in complementary and alternative medicine for the treatment of cancer

Effect of Conductive Filament Temperature on ZrO2 based Resistive Random Access Memory Devices

In the present work, the effect of reset voltage, filament radius, filament resistivity, and oxide membrane thickness on the nanoscale ZrO2 RRAM devices was reported. The present investigation is based on the thermal reaction model of RRAM. The outcomes show a decline in saturated temperature with a rise in the radius and resistivity of filament. Furthermore, increases in saturated temperature with an increase in oxide membrane thickness were observed for the ZrO2 based RRAM device. The saturated temperature of the device was mainly influenced by reset voltage, oxide layer thickness, filament size, and filament resistivity. The simulation results of the present investigation can be beneficial for the optimization of RRAM devices

Performance Evaluation of IARI Wheat Seed-cum-Fertilizer Plot Drill for Pearl Millet-Wheat Cropping System on Permanent Raised Bed System

A four-row IARI seed-cum-fertilizer plot drill developed at ICAR-IARI, New Delhi for permanent raised bed system was evaluated under pearl millet-wheat cropping system. The machine was fitted with two Oyjord metering mechanisms with four outlets for metering seed and fertilizer. Successful seeding on raised beds with pearl millet crop residue was achieved by first cutting the plant residue with a plain disc coulter, followed by seed drilling in narrow slit furrows opened by double disk furrow openers. The plot drill required 33.56 kW tractor for its operation in sandy loam soils, and two operators to feed measured quantity of seed and fertilizer. Field capacity of the plot drill was 0.17 ha.h-1 at 1.5 km.h-1 forward speed of operation. Field machine index, field efficiency and cost of operation were 72.72, 80 % and ` 648/- per hour, respectively. The plant stands of wheat sown on permanent raised beds with the developed plot drill were significantly higher than with precision plot drill

Integrated Management of Charcoal Rot and Its Influence on Seed Yield and Quality in Soybean

Charcoal rot (Macrophomina phaseolina) causes high grain yield loss in major soybean-growing nations worldwide. The present study aimed to reveal the effect of stage-wise charcoal rot incidence and their root and stem severity index on the yield criteria of soybean varieties. Additionally, an attempt was made to derive integrated management practices and their influence on seed quality. All the twelve varieties were affected by charcoal rot, and its incidence and root and stem severity index were high in Shivalik (48.5% and 3.7, respectively). In yield estimation, the percentage of yield loss ranged from 8.7% (JS 20-98) to 53.9% (Shivalik). Percent yield loss had a strong significant positive relation with percent incidence (0.912**) and Root and Stem severity index (0.813**) of charcoal rot. Seed treatment of Penflufen 13.28% + Trifloxystrobin 13.28 % FS @ 1ml/kg followed by spraying of tebuconazole 25% EC @ 0.1 % spraying at 45,60,75 days was significantly superior in reducing charcoal rot (19.7%) in comparison to untreated (37.3%). The highest seed germination (80.0 %) and least association with M. phaseolina (13.33%), Aspergillus flavus (3.33%), Fusarium sp., (13.34%) in comparison to control (50, 36.67, 23.33 and 36.67 %, respectively) were also resulted from the seed obtained from above treatment. In bioagent, seed treatment of T. harzianum @ 10 gm/kg followed by foliar spray of tebuconazole 25% EC @ 0.1% at 45,60,75 days was the second-best combination among all treatments in all respects. The effect of these fungicides and bio agents as seed treatment also improved the number of branches, pods, 100 seed weight and yield. Hence, these combinations could be applied to minimize charcoal rot and yield losses in soybean.&nbsp

Multidimensional Scope, Current Status, Uses and Contribution of Green Gold Bamboo: A Comprehensive Review

Bamboo is a versatile group of fastest growing plant which is capable of providing ecological, economical, environmental and livelihood security to the people. The study investigates uses, contribution, scope of the green gold plant bamboo. The review of this study showed that bamboo has evolved into a highly valuable and superior plant which serves for food, fodder and many more also bamboo-based products have the potential to replace wood, plastics in a variety of industrial uses without harming the nature by maintaining sustainability. So in this review paper comprehensive overview of the recent literatures about multidimensional scope of bamboo in form of its greatest potential is being discussed

LC-MS/MS method for the simultaneous quantification of luteolin, wedelolactone and apigenin in mice plasma using hansen solubility parameters for liquid-liquid extraction: application to pharmacokinetics of Eclipta alba chloroform fraction

Eclipta alba (Bhringraj) in ayurveda has been widely used as a traditional medicine for its multi-therapeutic properties for ages. Luteolin (LTL), wedelolactone (WDL) and apigenin (APG) are the three main bioactive phytochemicals present in Eclipta alba extract. However there was a lack of sensitive bioanalytical method for the pharmacokinetics of these free compounds in plasma which majorly contributes for their activities after oral administration of Eclipta alba. The present study aims to develop a sensitive, rapid and reliable liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the simultaneous estimation of mice plasma concentrations of LTL, WDL and APG using quercetin as an internal standard for the pharmacokinetic analysis. Analytes were separated on Phenomenex Luna C18 (150 × 4.6 mm, 3.0 μm) column with mobile phase containing methanol: acetonitrile (90: 10, v/v) and 0.1% formic acid in 10 mM ammonium formate buffer in the ratio of 70: 30 (v/v) in isocratic mode. Liquid-liquid extraction was optimized using Hansen solubility parameters and diethyl ether finalized as an extraction solvent for the recovery ranging from 61 to 76% for all analytes in mice plasma. The validated method has an accuracy and precision over the linearity range of 0.1–200 ng/mL with a correlation coefficient (r2) of ≥0.997. The intra and inter-day assay accuracy was between 98.17 and 107% and 95.83–107.89% respectively and the intra and inter day assay precision ranged from 0.37–6.05% and 1.85–10.76%, respectively for all the analytes. This validated method can be used for future clinical investigation studies of Eclipta alba extracts