20 research outputs found

    Dynamics of BPS States in the Dirac-Born-Infeld Theory

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    The Dirac-Born-Infeld action with transverse scalar fields is considered to study the dynamics of various BPS states. We first describe the characteristic properties of the so-called 1/2 and 1/4 BPS states on the D3 brane, which can be interpreted as F/D-strings ending on a D3-brane in Type IIB string theory picture. We then study the response of the BPS states to low energy excitations of massless fields on the brane, the scalar fields representing the shape fluctuation of the brane and U(1) gauge fields describing the open string excitations on the D-brane. This leads to an identification of interactions between BPS states including the static potentials and the kinetic interactions.Comment: 19 pages, 4 figures References added, Typographical errors are correcte

    Correction : A global overview of the genetic and functional diversity in the helicobacter pylori cag pathogenicity island

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    The Helicobacter pylori cag pathogenicity island (cagPAI) encodes a type IV secretion system. Humans infected with cagPAI–carrying H. pylori are at increased risk for sequelae such as gastric cancer. Housekeeping genes in H. pylori show considerable genetic diversity; but the diversity of virulence factors such as the cagPAI, which transports the bacterial oncogene CagA into host cells, has not been systematically investigated. Here we compared the complete cagPAI sequences for 38 representative isolates from all known H. pylori biogeographic populations. Their gene content and gene order were highly conserved. The phylogeny of most cagPAI genes was similar to that of housekeeping genes, indicating that the cagPAI was probably acquired only once by H. pylori, and its genetic diversity reflects the isolation by distance that has shaped this bacterial species since modern humans migrated out of Africa. Most isolates induced IL-8 release in gastric epithelial cells, indicating that the function of the Cag secretion system has been conserved despite some genetic rearrangements. More than one third of cagPAI genes, in particular those encoding cell-surface exposed proteins, showed signatures of diversifying (Darwinian) selection at more than 5% of codons. Several unknown gene products predicted to be under Darwinian selection are also likely to be secreted proteins (e.g. HP0522, HP0535). One of these, HP0535, is predicted to code for either a new secreted candidate effector protein or a protein which interacts with CagA because it contains two genetic lineages, similar to cagA. Our study provides a resource that can guide future research on the biological roles and host interactions of cagPAI proteins, including several whose function is still unknown
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