International Journal of Smart Grid and Clean Energy 3D visualized data management for network devices based on multilevel caches

Abstract Three dimensional visualization technologies are dramatically improving convenience and efficiency in modern industrial managements. In this paper, a novel multilevel caches-based 3D visualization system for managing device data, which could be applied for displaying 3D scenes and processing device data simultaneously, is investigated. The system is fast-response, compared to conventional strategies. This work may provide helpful references and inspirations for applications about computer based visualization, complex data management and network communications

The N-terminal Phosphodegron Targets TAZ/WWTR1 Protein for SCF β-TrCP -dependent Degradation in Response to Phosphatidylinositol 3-Kinase Inhibition

The Hippo tumor suppressor pathway plays a major role in development and organ size control, and its dysregulation contributes to tumorigenesis. TAZ (transcriptional co-activator with PDZ-binding motif; also known as WWTR1) is a transcription co-activator acting downstream of the Hippo pathway, and increased TAZ protein levels have been associated with human cancers, such as breast cancer. Previous studies have shown that TAZ is inhibited by large tumor suppressor (LATS)-dependent phosphorylation, leading to cytoplasmic retention and ubiquitin-dependent degradation. The LATS kinase, a core component of the Hippo pathway, phosphorylates the C-terminal phosphodegron in TAZ to promote its degradation. In this study, we have found that the N-terminal phosphodegron of TAZ also plays a role in TAZ protein level regulation, particularly in response to different status of cellular PI3K signaling. GSK3, which can be inhibited by high PI3K via AKT-dependent inhibitory phosphorylation, phosphorylates the N-terminal phosphodegron in TAZ, and the phosphorylated TAZ binds to β-TrCP subunit of the SCFβ-TrCP E3 ubiquitin ligase, thereby leading to TAZ ubiquitylation and degradation. We observed that the TAZ protein level is elevated in tumor cells with high PI3K signaling, such as in PTEN mutant cancer cells. This study provides a novel mechanism of TAZ regulation and suggests a role of TAZ in modulating tissue growth and tumor development in response to PI3K signaling

Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC

Homoharringtonine, a plant alkaloid, has been reported to suppress protein synthesis and has been approved by the US Food and Drug Administration for the treatment of chronic myeloid leukemia. Here we show that in acute myeloid leukemia (AML), homoharringtonine potently inhibits cell growth/viability and induces cell cycle arrest and apoptosis, significantly inhibits disease progression in vivo, and substantially prolongs survival of mice bearing murine or human AML. Strikingly, homoharringtonine treatment dramatically decreases global DNA 5-hydroxymethylcytosine abundance through targeting the SP1/TET1 axis, and TET1 depletion mimics homoharringtonine’s therapeutic effects in AML. Our further 5hmC-seq and RNA-seq analyses, followed by a series of validation and functional studies, suggest that FLT3 is a critical down-stream target of homoharringtonine/SP1/TET1/5hmC signaling, and suppression of FLT3 and its downstream targets (e.g. MYC) contributes to the high sensitivity of FLT3-mutated AML cells to homoharringtonine. Collectively, our studies uncover a previously unappreciated DNA epigenome-related mechanism underlying the potent antileukemic effect of homoharringtonine, which involves suppression of the SP1/TET1/5hmC/FLT3/MYC signaling pathways in AML. Our work also highlights the particular promise of clinical application of homoharringtonine to treat human AML with FLT3 mutations, which accounts for more than 30% of total cases of AML

Sustainability of Bamboo-steel Composite Structures

Seven billion people living on the earth face a challenge of sustainability development. Construction sector, a huge source of carbon emission and energy consumption, should be handled responsively to the natural environment and human society. Sustainable construction material and intelligent design are required to achieve sustainable development. Bamboo is renewable, biodegradable, and available locally in many parts of the world. It grows fast and has a high strength to weight ratio. Bamboo has a great potential to be used as a sustainable construction material. The bamboo plywood fabricated through the process of crushing, hot-pressing, adhesive spreading and gluing, cold-pressing, and curing, has stable dimensions and it is hydrophobic, and resistant to fungi and bacteria attack. It can be bonded with thin-walled steel sheet by structural adhesive and strengthened by screws to form various composite structural members e.g. slabs, walls, columns, and beams. This study evaluates sustainability of these bamboo-steel composite structures. Lab testing has revealed excellent performances of the structural members. The case study performed in this study indicates the composite structures have lower cost, lower greenhouse gas emissions and energy consumptions than other traditional construction materials.</p

Incidence and risk factors of isolated calf muscular venous thrombosis after tibial plateau fractures surgery

Abstract Background The risks associated with deep vein thrombosis (DVT) have gained significant recognition over time. A prevalent form of distal DVT is isolated calf muscular venous thrombosis (ICMVT). Despite its common clinical occurrence, data on ICMVT subsequent to tibial plateau fracture (TPF) surgery are scarce. This study aimed to examine the epidemiological characteristics and associated risk factors (RFs) of ICMVT following TPF surgery. Methods For this retrospective analysis, we included patients from our hospital, who underwent TPF surgery between March 2017 and March 2021. Patients’ electronic medical records were reviewed, including admission details, fracture classification, surgical procedures, and laboratory biomarkers. The HSS (The American Hospital for Special Surgery) and Rasmussen scores were employed to evaluate the clinical effect. A Color Duplex Flow Imager (CDFI) was regularly used to detect pre- and postoperative venous thrombosis in the lower limbs. Finally, uni- and multivariate logistic regression analyses were used to identify independent RFs associated with ICMVT. Results Overall, 481 participants were recruited for analysis. Postoperative ICMVT occurred in 47 patients. All ICMVTs occurred on the affected side. Four of the 47 ICMVT patients exhibited sudden postoperative swelling in the affected limb. The HSS and Rasmussen scores in the non-ICMVT cohort (87.6 ± 8.2, 16.0 ± 1.7) were markedly different from the ICMVT cohort (84.8 ± 8.2, 15.5 ± 1.6) (p = 0.014, p = 0.031). This study finally identified five postoperative ICMVT-related RFs, which were age (> 55 years old) (OR 3.06; 95% CI 1.47–6.37; p = 0.003), gender (female) (OR 2.67; 95% CI 1.37–5.22; p = 0.004), surgical duration (> 114 min) (OR 3.14; 95% CI 1.44–6.85; p = 0.004), elevated white blood cell content (OR 2.85; 95% CI 1.47–5.51; p = 0.002), and hyponatremia (OR 2.31; 95% CI 1.04–5.12; p = 0.040). Conclusion The epidemiological findings of this study may help predict ICMVT risk after surgery thus facilitating the development of individualized clinical assessments and targeted prevention programs

Effect of Vacancies on Dynamic Response and Spallation in Single-Crystal Magnesium by Molecular Dynamic Simulation

The effect of vacancies on dynamic response and spallation in single-crystal magnesium (Mg) is investigated by nonequilibrium molecular dynamics simulations. The initial vacancy concentration (Cv) ranges from 0% to 2.0%, and the shock loading is applied along [0001] and [10&ndash;10] directions. The simulation results show that the effects of vacancy defects are strongly dependent on the shock directions. For shock along the [0001] direction, vacancy defects have a negligible effect on compression-induced plasticity, but play a role in increasing spall damage. In contrast, for shock along the [10&ndash;10] orientation, vacancy defects not only provide the nucleation sites for compression-induced plasticity, which mainly involves crystallographic reorientation, phase transition, and stacking faults, but also significantly reduce spall damage. The degree of spall damage is probably determined by a competitive mechanism between energy absorption and stress attenuation induced by plastic deformation. Void evolution during spallation is mainly based on the emission mechanism of dislocations. The {11&ndash;22} &lt;11&ndash;23&gt; pyramidal dislocation facilitates the nucleation of void in the [0001] shock, as well as the {1&ndash;100} &lt;11&ndash;20&gt; prismatic dislocation in the [10&ndash;10] shock. We also investigated the variation of spall strength between perfect and defective Mg at different shock velocities. The relevant results can provide a reference for future investigations on spall damage

High-Efficiency and Reliable Value Geometric Standard: Integrated Periodic Structure Reference Materials

Integrated periodic structure reference materials are crucial for calibration in optical instruments and micro-computed tomography (micro-CT), yet they face limitations concerning a restricted measurement range, a single pattern type, and a single calibration parameter. In this study, we address these challenges by developing integrated periodic structure reference materials with an expanded measurement range, diverse pattern types, and multiple calibration parameters through a combination of photolithography and inductively coupled plasma (ICP) etching process. These reference materials facilitate high-efficiency and multi-value calibration, finding applications in the calibration of optical instruments and micro-CT systems. The simulations were conducted using MATLAB (R2022b) to examine the structure-morphology changes during the single-step ICP etching process. The variation rules governing line widths, periods, etching depths, and side wall verticality in integrated periodic structure reference materials were thoroughly evaluated. Linewidths were accurately extracted utilizing an advanced image processing algorithm, while average period values were determined through the precise Fast Fourier Transform method. The experimental results demonstrate that the relative errors of line widths do not exceed 17.5%, and the relative errors of periods do not exceed 1.5%. Furthermore, precise control of the etching depth was achieved, ranging from 30 to 60 μm for grids with line widths 2–20 μm. The side wall verticality exhibited remarkable consistency with an angle of 90° ± 0.8°, and its relative error was found to be less than 0.9%

Unraveling the nature of thermally induced spin reorientation in NdFe1-xCrxO3

Understanding spin control mechanisms is an important part of condensed matter physics and the theoretical basis for designing spintronic devices. In this letter, based on four-sublattices molecular field theory, we propose that the underlying NdFe1-xCrxO3 magnetic mechanism is driven by spin reorientation sensitive to temperature. The actual coupling angular momentum, angle between the Nd3+ and Cr3+/Fe3+ moments at the given temperature is realized via the Nd3+ magnetic moment projection onto the Cr3+/Fe3+ plane. As the temperature increases, the angle between the moment of Nd3+ and the moment of Cr3+/Fe3+ decreases monotonically. In this work, the magnetic mechanism of NdFe1-xCrxO3 (x=0.1, 0.9), the close relationship between A/B angle and temperature are presented, which laid a theoretical foundation for the design of new multifunctional magnetic materials

Correlation between fat-to-muscle mass ratio and cognitive impairment in elderly patients with type 2 diabetes mellitus: a cross-sectional study

Abstract Background Fat to muscle mass ratio (FMR), a novel index integrating fat and muscle composition, has garnered attention in age-related conditions such as type 2 diabetes mellitus (T2DM) and neurodegenerative diseases. Despite this research on the relationship between FMR and cognitive impairment (CI) in T2DM remains scarce. This study aimed to investigate the sex-specific association between FMR and CI in elderly T2DM patients. Methods A total of 768 elderly (> 60 years) T2DM in-patients (356 men and 412 women) were recruited from the Department of Endocrinology at Tianjin Nankai University affiliated hospital. Bioelectrical Impedance Analysis (BIA) was used to assess body composition, and Montreal Cognitive Assessment (MoCA) was used to evaluate cognitive performance. T2DM patients were categorized into normal cognitive function (NC) and cognitive impairment (CI) groups based on MoCA scores and stratified by sex. Binary logistic regression was employed to examine the association between FMR and CI. Results Among the participants, 42.7% of men and 56.3% of women experienced cognitive deterioration. Women with CI exhibited lower body mass index (BMI) and skeletal muscle mass index (SMI), while men with cognitive disorders showed lower SMI, FMR, and higher fat mass index (FMI). FMR was consistently unrelated to cognition in females, irrespective of adjustment made. However, in males, FMR was significantly associated with an increasing risk of cognitive dysfunction after adjusting for demographic and clinical variables (OR: 1.175, 95% CI: 1.045–1.320, p = 0.007). Furthermore, for each 0.1 increase in FMR, the incidence of CI rose by 31.1% after additional adjustment for BMI. In males, the prevalence of CI increased sequentially across FMR quartiles (p < 0.05). Conclusion Elderly T2DM men with high FMR had unfavorable cognitive function. FMR is independently associated with an increased risk of CI in male T2DM patients regardless of BMI