97 research outputs found
Comprehensive analysis of PSME3: from pan-cancer analysis to experimental validation
PSME3 plays a significant role in tumor progression. However, the prognostic value of PSME3 in pan-cancer and its involvement in tumor immunity remain unclear. We conducted a comprehensive study utilizing extensive RNA sequencing data from the TCGA (The Cancer Genome Atlas) and GTEx (Genotype-Tissue Expression) databases. Our research revealed abnormal expression levels of PSME3 in various cancer types and unveiled a correlation between high PSME3 expression and adverse clinical outcomes, especially in cancers like liver cancer (LIHC) and lung adenocarcinoma (LUAD). Functional enrichment analysis highlighted multiple biological functions of PSME3, including its involvement in protein degradation, immune responses, and stem cell regulation. Moreover, PSME3 showed associations with immune infiltration and immune cells in the tumor microenvironment, indicating its potential role in shaping the cancer immune landscape. The study also unveiled connections between PSME3 and immune checkpoint expression, with experimental validation demonstrating that PSME3 positively regulates CD276. This suggests that PSME3 could be a potential therapeutic target in immunotherapy. Additionally, we predicted sensitive drugs targeting PSME3. Finally, we confirmed in both single-factor Cox and multiple-factor Cox regression analyses that PSME3 is an independent prognostic factor. We also conducted preliminary validations of the impact of PSME3 on cell proliferation and wound healing in liver cancer. In summary, our study reveals the multifaceted role of PSME3 in cancer biology, immune regulation, and clinical outcomes, providing crucial insights for personalized cancer treatment strategies and the development of immunotherapy
(Methoxo-κO)oxidobis(quinolin-8-olato-κ2 N,O)vanadium(V)
In the title complex, [V(C9H6NO)2(CH3O)O], the central VV atom is coordinated by the O atoms from the oxido and methoxo ligands and the N and O atoms of two bis-chelating quinolin-8-olate ligands, forming a distorted octaÂhedral environment. In the crystal structure, weak interÂmolecular C—H⋯O hydrogen bonds connect molÂecules into centrosymmetric dimers which are, in turn, linked by weak C—H⋯π interÂactions into chains along the b axis
The influence of the China GLIM standards on the diagnosis of malnutrition in patients with hematopoietic stem cell transplant
BackgroundThe muscle-related indicator is removed from Global Leadership Initiative on Malnutrition (GLIM) criteria implemented in China for many reasons. Patients with hematopoietic stem cell transplants are at nutrition risk and can enter into the second step of GLIM; thus, they are suitable for learning the diagnosing malnutrition significance between primary GLIM and GLIM-China criteria. This article aims to explore the role of muscle mass in the diagnostic criteria of malnutrition and the effects of GLIM-China for diagnosing malnutrition.MethodsA total of 98 inpatients with hematopoietic stem cell transplants (HSCT) were recruited. Nutrition risk was assessed by using the Nutritional Risk Screening 2002 (NRS-2002). Appendicular skeletal muscle mass (ASMI) and fat-free mass index (FFMI) were determined using the bioelectrical impedance analysis (BIA) method. Malnutrition is defined by GLIM-China, GLIM, and PG-SGA. We use erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) to assess inflammation in GLIM and GLIM-China. The correlation or consistency among ASMI, FFMI, ESR, CRP, GLIM-China, GLIM, and PG-SGA was evaluated, respectively.ResultsOne hundred percent instead of the patients had nutritional risk. The magnitude of malnutrition using PG-SGA, GLIM, and GLIM-China was 75.5, 80.6, and 64.3%, respectively. GLIM-China and PG-SGA showed the same performance (p = 0.052 vs. 1.00) and agreement (kappa = 0.404 vs. 0.433, p < 0.0001) with the FFMI. Consistency was noted between ASMI and PG-SGA in the assessment of malnutrition (p = 0.664) with a good agreement (kappa = 0.562, p = 0.084). ASMI and FFMI could determine muscle mass reduction, which could not be determined by BMI, albumin (ALB), and pre-albumin (pre-ALB); 34% of GLIM-China (–) patients were with low ASMI, and 40% with low FFMI; 30.0% of patients with PG-SGA (<4) still have low ASMI, and 38.2% have low FFMI.ConclusionIf only the PG-SGA scale is used as a diagnostic criterion for evaluating malnutrition, a large proportion of patients with reduced muscle mass will be missed, but more patients with muscle loss will be missed via GLIM-China. Muscle-related indicators will help diagnose malnutrition
An 18.9-minute Blue Large-Amplitude Pulsator Crossing the 'Hertzsprung Gap' of Hot Subdwarfs
Blue large-amplitude pulsators (BLAPs) represent a new and rare class of hot
pulsating stars with unusually large amplitudes and short periods. Up to now,
only 24 confirmed BLAPs have been identified from more than one billion
monitored stars, including a group with pulsation period longer than
min (classical BLAPs, hereafter) and the other group with pulsation period
below min. The evolutionary path that could give rise to such kinds of
stellar configurations is unclear. Here we report on a comprehensive study of
the peculiar BLAP discovered by the Tsinghua University - Ma Huateng Telescopes
for Survey (TMTS), TMTS J035143.63+584504.2 (TMTS-BLAP-1). This new BLAP has an
18.9 min pulsation period and is similar to the BLAPs with a low surface
gravity and an extended helium-enriched envelope, suggesting that it is a
low-gravity BLAP at the shortest-period end. In particular, the long-term
monitoring data reveal that this pulsating star has an unusually large rate of
period change, P_dot/P=2.2e-6/yr. Such a significant and positive value
challenges its origins from both helium-core pre-white-dwarfs and core
helium-burning subdwarfs, but is consistent with that derived from shell
helium-burning subdwarfs. The particular pulsation period and unusual rate of
period change indicate that TMTS-BLAP-1 is at a short-lived (~10^6 yr) phase of
shell-helium ignition before the stable shell-helium burning; in other words,
TMTS-BLAP-1 is going through a "Hertzsprung gap" of hot subdwarfs.Comment: 26 pages, 12 figures, 4 tables, published on Nature Astronomy, URL:
https://www.nature.com/articles/s41550-022-01783-
Anatomical and Physiological Plasticity in Leymus chinensis (Poaceae) along Large-Scale Longitudinal Gradient in Northeast China
Although it has been widely accepted that global changes will pose the most important constrains to plant survival and distribution, our knowledge of the adaptive mechanism for plant with large-scale environmental changes (e.g. drought and high temperature) remains limited.An experiment was conducted to examine anatomical and physiological plasticity in Leymus chinensis along a large-scale geographical gradient from 115° to 124°E in northeast China. Ten sites selected for plant sampling at the gradient have approximately theoretical radiation, but differ in precipitation and elevation. The significantly increasing in leaf thickness, leaf mass per area, vessel and vascular diameters, and decreasing in stoma density and stoma index exhibited more obvious xerophil-liked traits for the species from the moist meadow grassland sites in contrast to that from the dry steppe and desert sites. Significant increase in proline and soluble sugar accumulation, K(+)/Na(+) for the species with the increasing of stresses along the gradient showed that osmotic adjustment was enhanced.Obvious xerophytic anatomical traits and stronger osmotic adjustment in stress conditions suggested that the plants have much more anatomical and physiological flexibilities than those in non-stress habitats along the large-scale gradient
Mixing fraction in classical novae
Context. Classical novae are powered by thermonuclear runaways occurring on
the surface of accreting white dwarfs (WDs). In the observations, the
enrichments of heavy elements in nova ejecta have been detected, indicating a
mixing process between the accreted matter and the matter from the outer layers
of the underlying WDs prior to nova outbursts. However, the mixing fraction in
classical novae is still uncertain.
Aims. The purpose of this article is to investigate some elemental abundance
ratios during nova outbursts that can be used to estimate the WD mixing
fraction in classical novae.
Methods. By considering different WD mixing fractions with the stellar
evolution code Modules for Experiments in Stellar Astrophysics (MESA), we
carried out a series of simulations of nova outbursts, in which the initial CO
WD masses range from .
Results. We identified four elemental abundance ratios (i.e. , , and ) that satisfy
the conditions for determining the WD mixing fraction, in which is the most suitable mixing meter. We also estimated the WD
mixing fraction in some representative classical novae. Additionally, we found
that a higher metallicity (i.e. higher WD mixing fraction) is preferentially
accompanied by a longer (the time of decline by two magnitudes from
peak luminosity) during nova outbursts. Our results can be used to constrain
the mixing process in classical novae.Comment: 14 pages, 6 figures, 2 tables, accepted for publication in A&
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