Mapping topology-disorder phase diagram with a quantum simulator

We explore the topology-disorder phase diagram by simulating one-dimensional Su-Schrieffer-Heeger (SSH) model with quasiperiodic disorder using a programmable superconducting simulator. We experimentally map out and identify various trivial and topological phases with extended and localized bulk states. We find that in the topological phase the bulk states can be critically localized without mobility edge or contain both critically and completely localized states. In addition, there exist trivial and topological intermediate phases with mobility edge and coexistence of extended and completely localized states. The presence of the surprisingly rich phases in the simple SSH model with quasiperiodic disorder sheds new light on the investigation of the topological and localization phenomena in condensed-matter physics.Comment: 5 pages, 4 figure

The Polypyrrole/Multiwalled Carbon Nanotube Modified Au Microelectrode for Sensitive Electrochemical Detection of Trace Levels of Pb2+

The sensitive detection of trace levels of heavy metal ions such as Pb2+ is of significant importance due to the health hazard they pose. In this paper, we present a polypyrrole (PPy)/multiwalled carbon nanotube (MWCNT)-modified Au microelectrode. The PPy/MWCNT composite film was electrochemically deposited on the microelectrode by cyclic voltammetry (CV). The composite film was investigated by scanning electron microscope (SEM), CV, and electrochemical impedance spectroscopy (EIS), and the results show that this film presents a uniformly distributed and web-like entangled structure and good conductivity. Differential pulse stripping voltammetry (DPSV) was applied to determine trace levels of Pb2+. Experimental conditions including accumulation time and deposition potential were optimized. In optimal conditions, the PPy/MWCNT-modified microelectrode performed sensitive detection of Pb2+ within a concentration range from 1 to 100 μg·L−1, and the limit of detection was 0.65 μg·L−1 at the signal-to-noise ratio of three

Heparanase contributes to psoriatic lesions through crosstalk with IL-17 pathway

Psoriasis is a chronic inflammatory disease that is considered by a network of immunocytes and cytokines. Among all, Th17 cells–derived IL-17 is a critical driving factor in the pathogenesis of psoriasis. Recently, disruption of the extracellular matrix was found to be related to psoriasis progression. In the present study, we aimed to investigate the role of heparanase (HPSE) in psoriasis and the crosstalk with the IL-17 signalling pathway. Skin tissues from non-affected areas and psoriatic lesion areas before and after 12 weeks of IL-17 monoclonal antibody treatment of 30 psoriasis patients were collected. HaCaT cells were treated with different concentrations of IL-17 antibody, and HPSE in cells and medium were measured with Western blotting assay as well as enzyme-linked immunosorbent assay (ELISA). In the imiquimod (IMQ)-induced psoriasis model, IL-17 protein and mRNA expression levels were measured, and changes in the proportion of Th17 cells were detected via flow cytometry. Our data showed that HPSE is upregulated in lesion tissues isolated from psoriasis patients, and was inhibited by anti-IL-17 treatment. In cutaneous cells and IMQ-induced psoriasis model, IL-17 promoted the synthesis of HPSE. Inversely, HPSE was also found to increase the percentage of Th17 cells derived from CD4+ T cells. Finally, we found that the combined treatments of HPSE inhibitor and IL-17 monoclonal antibody produced therapeutic effects on IMQ-induced psoriasis model. Our findings revealed the new role of HPSE in the pathogenesis of psoriasis and also provided a target for combined treatment of psoriasis

Numerical and experimental study on monitoring coal cracks with PZT sensor

Abstract The rupture of coal pillar can lead to spontaneous combustion or collapse of goaf, which endangers the safety of workers. To explore the relationship between the crack depth of the coal structure and the signal received by the piezoelectric ceramic sensor, the output data of coal samples were analyzed by using the piezoelectric effect, combined with the experiment and ABAQUS simulation. Based on the signal amplitude, the output signal characteristics of the coal model with different crack depths were analyzed, and the evaluation index of coal crack cracking degree (D c ) was defined. The results show that the piezoelectric fluctuation method can effectively identify the local cracks of coal. When the distance between the lead Piezoelectric Transducer (PZT) patch and crack position is constant, the amplitude of the PZT patch output signal will decay with the deepening of the crack depth, while the value of increases with the increase of crack depth. This study provides a theoretical basis for mine disaster prevention and control

Study of the Fire Behavior of Multilayer Cables in a Mine Tunnel

Fires caused by cables occur frequently in mines, which endanger the safety of workers. To explore the characteristics of a multilayer cable fire in a mine tunnel, multilayer cable fire simulations were carried out using the Fire Dynamics Simulator (FDS). The influence of cable tray spacing, ignition position, and tunnel ventilation speed on the characteristics of the fire were studied. The results showed that these factors change the amount of contact between the cable and air, the heat accumulation, and the heat transfer by the flame interaction between the cables. It was also noted that increasing the spacing or wind speed both made the peak of heat release rate (PHRR) initially increase and then decrease. The influence of wind speed on the cable burnout rate in the upstream and downstream sides of the fire source was not consistent, and the wind speed had a sensitive effect on the cable burn out rate in the upstream side of the fire source. The higher the ignition position was, the longer the arrival time of PHRR was and the slower the fire developed. There was a higher burn velocity close to the ceiling. The cable hooks obstructed the cable fire. This study provides a theoretical basis for cable fire prevention and control in mine tunnels

Study of the Fire Behavior of Multilayer Cables in a Mine Tunnel

Fires caused by cables occur frequently in mines, which endanger the safety of workers. To explore the characteristics of a multilayer cable fire in a mine tunnel, multilayer cable fire simulations were carried out using the Fire Dynamics Simulator (FDS). The influence of cable tray spacing, ignition position, and tunnel ventilation speed on the characteristics of the fire were studied. The results showed that these factors change the amount of contact between the cable and air, the heat accumulation, and the heat transfer by the flame interaction between the cables. It was also noted that increasing the spacing or wind speed both made the peak of heat release rate (PHRR) initially increase and then decrease. The influence of wind speed on the cable burnout rate in the upstream and downstream sides of the fire source was not consistent, and the wind speed had a sensitive effect on the cable burn out rate in the upstream side of the fire source. The higher the ignition position was, the longer the arrival time of PHRR was and the slower the fire developed. There was a higher burn velocity close to the ceiling. The cable hooks obstructed the cable fire. This study provides a theoretical basis for cable fire prevention and control in mine tunnels

Determination of Norfloxacin and Ciprofloxacin in Chicken Meat Based on Matrix Solid-Phase Dispersion Extraction and Capillary Zone Electrophoresis

This study describes an effective matrix solid-phase dispersion (MSPD) extraction method for determining norfloxacin (NOR) and ciprofloxacin (CIP) in chicken meat by capillary zone electrophoresis (CZE). The optimum conditions for separating NOR and CIP were as follows: 60 cm×75 μm i.d. capillary, 40 mmol L−1 borate buffer solution (pH 8.5), separation voltage at 16 kV, and detection wavelength at 280 nm. Before CZE determination, the chicken meat samples were purified and enriched by using an MSPD extraction step with a preconditioned C18 cartridge and by eluting the compound with 3.0 mL of acetonitrile. A good linear fit curve with the concentration range of 0.10 μg g−1 to 500 μg g−1 for NOR and CIP was obtained, with regression coefficients of 0.9994 and 0.9986, respectively. The limits of detection of NOR and CIP were 0.04 and 0.03 μg g−1, respectively. The proposed method was successfully applied to determine NOR and CIP in chicken meat