Comparative Analysis of Clinical Epidemiology and Pathological Characteristics of 908 Patients with Primary Lung Cancer of Hunan Province in 1997 and 2007

Background and objective Epidemiology of lung cancer will be changed along with time and region. The aim of this study is to acknowledge the tendency of primary lung cancer in hunan province in recent years by comparing and analyzing the distribution of gender, age, area, smoking and pathology of patients who were initial diagnosed lung cancer and ancestral or permanent residence of hunan province in 1997 and 2007. Methods Clinical data of 908 patients with primary lung cancer hospitalized in Xiangya hospital were collected and evaluated. Results Compared patients in 2007 with those in 1997, ratio between male and female dropped from 3.8:1 to 2.98:1, while the proportion of young patients who were under 40 years old raised from 4.4% to 8.6% (χ2=4.465, P=0.035), patients living in the county raised from 19.9% to 40.1% (χ2=30.670, P < 0.001), smoking rate of patients from county raised from 16.9% to 39.9% (χ2= 24.939, P < 0.01). In addition, the proportion of rare histological types of lung cancer were also increased from 1.3% to 4.5% (χ2= 5.142, P=0.023). Conclusion Female patients, young patients, rural patients and rare histological types of lung cancer may have a tendency of increase in hunan province in recent years, whereas smoking cessation education should be strengthened

Pressure induced color change and evolution of metallic behavior in nitrogen-doped lutetium hydride

By applying pressures up to 42 GPa on the nitrogen-doped lutetium hydride (LuH$_{2\pm\text{x}}$N$_y$), we have found a gradual change of color from dark-blue to pink-violet in the pressure region of about 12 GPa to 21 GPa. The temperature dependence of resistivity under pressures up to 50.5 GPa shows progressively optimized metallic behavior with pressure. Interestingly, in the pressure region for the color change, a clear decrease of resistivity is observed with the increase of pressure, which is accompanied by a clear increase of the residual resistivity ratio (RRR). Fitting to the low temperature resistivity gives exponents of about 2, suggesting a Fermi liquid behavior in low temperature region. The general behavior in wide temperature region suggests that the electron-phonon scattering is still the dominant one. The magnetoresistance up to 9 tesla in the state under a pressure of 50.5 GPa shows an almost negligible effect, which suggests that the electric conduction in the pink-violet state is dominated by a single band. It is highly desired to have theoretical efforts in understanding the evolution of color and resistivity in this interesting system.Comment: 15 pages, 4 figure

Absence of near-ambient superconductivity in LuH2±x_{2\pm\text{x}}Ny_y

Recently near-ambient superconductivity was claimed in N-doped lutetium hydride (ref. 1). This induces a worldwide fanaticism about the dream of room temperature superconductivity under low pressures. By using a high pressure and high temperature synthesis technique, we have successfully obtained the nitrogen doped lutetium hydride (LuH$_{2\pm\text{x}}$N$_y$) with a dark-bluish color and a structure with the space group of $Fm\bar{3}m$ evidenced by x-ray diffraction. This structure is the same as that reported in ref. 1. The energy dispersive X-ray spectroscopy (EDS) confirmed the existence of nitrogen in some areas of the samples. At ambient pressure, we witness a kink of resistivity and magnetization at about 300 K, which may correspond to a rearrangement of hydrogen/nitrogen atoms, namely a structural transition. However, by applying a pressure from 1 GPa to 6 GPa, we have seen a progressively optimized metallic behavior without showing superconductivity down to 10 K. Temperature dependence of magnetization shows a roughly flat feature between 100 and 320 K, and the magnetization increases with magnetic field at 100 K, all these are not expected for superconductivity at 100 K. Thus, we conclude the absence of near-ambient superconductivity in this nitrogen-doped lutetium hydride under pressures below 6 GPa.Comment: An updated version with more data was published in Nature online on 11th May 2023 as an Accelerated Article Preview for

Clinical implications of trichomonads detected in bronchoalveolar fluid by metagenomic next-generation sequencing: a multicenter retrospective study

BackgroundPulmonary trichomoniasis is considered a neglected disease due to failures in recognizing it, stemming from insensitive microbial methods and a lack of specific clinical features. This study aims to analyze the clinical implications of trichomonads detected in bronchoalveolar lavage fluid (BALF) by metagenomic next-generation sequencing (mNGS).MethodsThis multicenter retrospective study included patients diagnosed with pneumonia, admitted to three tertiary hospitals in China from July 2018 to September 2022, with trichomonads detected in BALF through mNGS. The analysis covered demographics, comorbidities, symptoms, laboratory findings, mNGS results, clinical treatment, and outcomes of these patients.ResultsA total of 17 patients were enrolled, comprising 14 males and 3 females. Trichomonas tenax and Trichomonas vaginalis were detected by mNGS in BALF samples of 15 and 2 patients, respectively. Patients were categorized into two groups based on the presence of risk factors for trichomonad infection, including immunocompromised conditions, uncontrolled diabetes mellitus, oral/periodontal diseases, and aspiration. Among 11 patients with risk factors (Case 1-11), 4 received nitromidazoles as part of comprehensive treatment, achieving a 100% treatment success rate. The remaining 7 patients, who did not receive nitromidazoles, had only one achieving relief after broad-spectrum antimicrobial therapy, resulting in a 14.3% treatment success rate. For the 6 patients without any risk factors for trichomonad infection (Case 12-17), none received nitromidazoles during hospitalization. However, 4 out of these 6 patients (66.7%) eventually recovered.ConclusionmNGS proves to be an efficient tool for detecting trichomonads in BALF samples. Comprehensive analysis of clinical features and laboratory indicators is essential to distinguish between infection and colonization of trichomonads. Pulmonary trichomoniasis should not be overlooked when trichomonads are detected in BALF from patients with risk factors