READIN: A Chinese Multi-Task Benchmark with Realistic and Diverse Input Noises

For many real-world applications, the user-generated inputs usually contain various noises due to speech recognition errors caused by linguistic variations1 or typographical errors (typos). Thus, it is crucial to test model performance on data with realistic input noises to ensure robustness and fairness. However, little study has been done to construct such benchmarks for Chinese, where various language-specific input noises happen in the real world. In order to fill this important gap, we construct READIN: a Chinese multi-task benchmark with REalistic And Diverse Input Noises. READIN contains four diverse tasks and requests annotators to re-enter the original test data with two commonly used Chinese input methods: Pinyin input and speech input. We designed our annotation pipeline to maximize diversity, for example by instructing the annotators to use diverse input method editors (IMEs) for keyboard noises and recruiting speakers from diverse dialectical groups for speech noises. We experiment with a series of strong pretrained language models as well as robust training methods, we find that these models often suffer significant performance drops on READIN even with robustness methods like data augmentation. As the first large-scale attempt in creating a benchmark with noises geared towards user-generated inputs, we believe that READIN serves as an important complement to existing Chinese NLP benchmarks. The source code and dataset can be obtained from https://github.com/thunlp/READIN.Comment: Preprin

CT-based Subchondral Bone Microstructural Analysis in Knee Osteoarthritis via MR-Guided Distillation Learning

Background: MR-based subchondral bone effectively predicts knee osteoarthritis. However, its clinical application is limited by the cost and time of MR. Purpose: We aim to develop a novel distillation-learning-based method named SRRD for subchondral bone microstructural analysis using easily-acquired CT images, which leverages paired MR images to enhance the CT-based analysis model during training. Materials and Methods: Knee joint images of both CT and MR modalities were collected from October 2020 to May 2021. Firstly, we developed a GAN-based generative model to transform MR images into CT images, which was used to establish the anatomical correspondence between the two modalities. Next, we obtained numerous patches of subchondral bone regions of MR images, together with their trabecular parameters (BV / TV, Tb. Th, Tb. Sp, Tb. N) from the corresponding CT image patches via regression. The distillation-learning technique was used to train the regression model and transfer MR structural information to the CT-based model. The regressed trabecular parameters were further used for knee osteoarthritis classification. Results: A total of 80 participants were evaluated. CT-based regression results of trabecular parameters achieved intra-class correlation coefficients (ICCs) of 0.804, 0.773, 0.711, and 0.622 for BV / TV, Tb. Th, Tb. Sp, and Tb. N, respectively. The use of distillation learning significantly improved the performance of the CT-based knee osteoarthritis classification method using the CNN approach, yielding an AUC score of 0.767 (95% CI, 0.681-0.853) instead of 0.658 (95% CI, 0.574-0.742) (p<.001). Conclusions: The proposed SRRD method showed high reliability and validity in MR-CT registration, regression, and knee osteoarthritis classification, indicating the feasibility of subchondral bone microstructural analysis based on CT images.Comment: 5 figures, 4 table

Sub-Character Tokenization for Chinese Pretrained Language Models

Tokenization is fundamental to pretrained language models (PLMs). Existing tokenization methods for Chinese PLMs typically treat each character as an indivisible token. However, they ignore the unique feature of the Chinese writing system where additional linguistic information exists below the character level, i.e., at the sub-character level. To utilize such information, we propose sub-character (SubChar for short) tokenization. Specifically, we first encode the input text by converting each Chinese character into a short sequence based on its glyph or pronunciation, and then construct the vocabulary based on the encoded text with sub-word tokenization. Experimental results show that SubChar tokenizers have two main advantages over existing tokenizers: 1) They can tokenize inputs into much shorter sequences, thus improving the computational efficiency. 2) Pronunciation-based SubChar tokenizers can encode Chinese homophones into the same transliteration sequences and produce the same tokenization output, hence being robust to all homophone typos. At the same time, models trained with SubChar tokenizers perform competitively on downstream tasks. We release our code at https://github.com/thunlp/SubCharTokenization to facilitate future work.Comment: This draft supersedes the previous version named "SHUOWEN-JIEZI: Linguistically Informed Tokenizers For Chinese Language Model Pretraining

Simulation of tumor ablation in hyperthermia cancer treatment: A parametric study

A holistic simulation framework is established on magnetic hyperthermia modeling to solve the treatment process of tumor, which is surrounded by a healthy tissue block. The interstitial tissue fluid, MNP distribution, temperature profile, and nanofluids are involved in the simulation. Study evaluates the cancer treatment efficacy by cumulative-equivalent-minutes-at-43 centigrade (CEM43), a widely accepted thermal dose coming from the cell death curve. Results are separated into the conditions of with or without gravity effect in the computational domain, where two baseline case are investigated and compared. An optimal treatment time 46.55 min happens in the baseline case without gravity, but the situation deteriorates with gravity effect where the time for totally killing tumor cells prolongs 36.11% and meanwhile causing 21.32% ablation in healthy tissue. For the cases without gravity, parameter study of Lewis number and Heat source number are conducted and the variation of optimal treatment time are both fitting to the inverse functions. For the case considering the gravity, parameters Buoyancy ratio and Darcy ratio are investigated and their influence on totally killing tumor cells and the injury on healthy tissue are matching with the parabolic functions. The results are beneficial to the prediction of various conditions, and provides useful guide to the magnetic hyperthermia treatment