The Crural Interosseous Membrane Re-visited: a Histological and Microscopic Study

The aim of this study was to characterize the microscopic structure and sensory nerve endings of the crural interosseous membrane (IM). 13 IMs from 7 cadavers were used to analyze the organization of the collagen fibers, IM’s thickness, distribution of elastic fibers and nerve elements. The IM is mainly a two-layer collagen fascicle structure with the collagen fibers of adjacent layers orientated along different directions, forming angles of 30.5 +/- 1.7° at proximal and 26.6 +/- 2.1° at distal part (P>0.05). The percentage of elastic fibers between the two layers and inside the collagen fascicle layer is 10.1 +/- 0.5% and 2.2 +/- 0.1% (P<0.001). The IM’s thickness at proximal, middle, and distal parts is 268.5 +/- 18.6μm; 293.2 +/- 12.5μm; 365.3 +/- 19.3 μm, respectively (Proximal vs Distal: P<0.001; Middle vs Distal: P<0.05). Nerve elements were present and located both inside and on the surface of the IM, whereas the mechanoreceptors are mainly located on the surface of the IM. Free nerve endings (33.3 +/- 5.0/cm2) and Ruffini corpuscles (3.4 +/- 0.6/cm2) were the predominant sensory elements, while Pacinian corpuscles (1.3 +/- 0.7/cm2) were rarely found. The type of mechanoreceptors found suggests that the IM may play a role in proprioception.https://doi.org/10.4081/ejtm.2019.834

T cell-derived exosomes in tumor immune modulation and immunotherapy

Exosomes are nanoscale vesicles secreted by most cells and have a phospholipid bilayer structure. Exosomes contain DNA, small RNA, proteins, and other substances that can carry proteins and nucleic acids and participate in communication between cells. T cells are an indispensable part of adaptive immunity, and the functions of T cell-derived exosomes have been widely studied. In the more than three decades since the discovery of exosomes, several studies have revealed that T cell-derived exosomes play a novel role in cell-to-cell signaling, especially in the tumor immune response. In this review, we discuss the function of exosomes derived from different T cell subsets, explore applications in tumor immunotherapy, and consider the associated challenges

BLOOM: A 176B-Parameter Open-Access Multilingual Language Model

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License

Research of a Novel Non-Axisymmetric Side-Compressed Variable Polarity Plasma Arc and Its Pressure Distribution Characteristics

In the keyhole variable polarity plasma arc weldng (VPPAW) process at horizontal position, the metal driven by gravity gathered on one side of the molten pool, and the weld formation is difficult, especially for thick workpiece welding. A specially designed experiment to analyze the influence of gravity on weld formation and a novel nozzle structure with side holes was proposed to generate a novel non-axisymmetric side-compressed plasma arc and redistribute arc pressure. The arc shape and pressure distribution were studied, and the ratio of difference for arc pressure in different directions Rp was introduced to evaluate the effects of non-axisymmetric side compression for the plasma arc. The results indicate that the non-axisymmetric distributed side holes reshape the plasma arc both in the EN and EP phases. The pressure of the non-axisymmetric side-compressed plasma arc decreases relatively strongly in one direction (direction b) and relatively weakly in the other direction (direction a). Rp is significant at 1 mm to 5 mm from the arc center, with a relatively large Rp within this range. The compression effect is enhanced with an increase in welding current or plasma gas flow rate, and Rp increases from 24% to 49% as the plasma gas flow rate increases from 2 L/min to 4.5 L/min. Specially designed validation experiments confirm that the new plasma arc significantly affects the weld formation in keyhole VPPAW process. An aluminum alloy workpiece with 8 mm thickness and no groove preparation was welded by the novel plasma arc in a horizontal welding position, and the weld is well formed

Study on Pores in Ultrasonic‐Assisted TIG Weld of Aluminum Alloy

Ultrasonic‐assisted tungsten inert gas welding was carried out on a thin plate of 2195 Al‐Li alloy, and the characteristics of the weld pores were analyzed in terms of their size and porosity. The effects of welding speed and ultrasonic power on the porosity and size of the pores were investigated. The pores were found to occur primarily adjacent to the surface of the weld. The porosity decreased and the size increased with a decrease in welding speed. The effect of ultrasonic power on the characteristics of the pores was different from that of the welding speed. The porosity and size of the pores decreased and then increased with an increase in ultrasonic power. A relationship was found between the transient cavitation intensity and the characteristics of pores. An increasing transient cavitation intensity results in a decrease in the porosity and size of pores when the transient cavitation intensity is lower. However, it can result in an increase in the porosity and pore size when the transient cavitation intensity further increases. Finally, the influencing mechanism of cavitation on welding pores was discussed

Characteristics of Periodic Ultrasonic Assisted TIG Welding for 2219 Aluminum Alloys

Tungsten inert gas (TIG) arc welding of 2219 aluminum alloy was assisted with a trailing periodic ultrasonic vibration, which was output from a trailing roller behind the welding torch. It was found that the weld appearance was periodically convex due to the periodic input of ultrasonic vibration. With the addition of ultrasonic vibration, the columnar grains in the weld zone transformed to equiaxed grains, so along the longitudinal direction, the equiaxed grains and the columnar grains were alternately distributed due to the periodic ultrasonic vibration. The effects of different ultrasonic powers were investigated. The penetration depth and the amount of the melting metal both increased as the ultrasonic power increased. The coarse precipitated phases in the weld zone tended to disperse uniformly under ultrasonic vibration. Compared with conventional TIG welded joints, the hardness of the weld zone of the ultrasonic assisted TIG welding increased by 8.43%, and the tensile strength increased by 29.02%. The ultrasonic cavitation could decrease the nucleation radius and break the dendrites, which led to the grains&rsquo; refinement and the final mechanical properties&rsquo; improvement

Influence of heat input on the appearance, microstructure and microhardness of pulsed gas metal arc welded Al alloy weldment

In order to achieve high-quality welding of aluminum alloys, reasonable control of welding heat input is critical. Different combinations of welding parameters can achieve the same heat input, however, the relevant research results has not been reported. In this paper, the pulsed-gas metal arc welding (P-GMAW) of 4047 Al–Si alloy was used as the research object. Combining design of welding current, welding voltage and welding speed, three sets of welding parameters with the same heat input were obtained, and welding experiments were carried out on them. The formation, microstructure and mechanical properties of weld bead were analyzed. The results show that under the same heat input, the effect of the welding current and voltage on the weld bead is remarkable. With the increase of the two, the penetration, width and spreadability of the weld bead increased, and the low melting point precipitates became more aggregated. At the same time, the average hardness of the weld increased from 98.27 HV to 104.4 HV, i.e., 6.2%

Numerical Analysis of Physical Characteristics and Heat Transfer Decoupling Behavior in Bypass Coupling Variable Polarity Plasma Arc

A novel bypass coupling variable polarity plasma arc was proposed to achieve the accurate adjusting of heat and mass transfer in the welding and additive manufacturing of aluminum alloy. However, the physical characteristics and decoupled transfer behavior remain unclear, restricting its application and development. A three-dimensional model of the bypass coupling variable polarity plasma arc was built based on Kirchhoff’s law, the main arc and the bypass arc are coupled by an electromagnetic field. The model of current attachment on the tungsten electrode surface is included for simulating different heating processes of the EP and EN phases in the coupling arc. The distribution of temperature field, flow field, and current density of the bypass coupling variable polarity plasma arc was studied by the three-dimensional numerical model. The heat input on the base metal under different current conditions is quantified. To verify the model, the arc voltages are compared and the results in simulation and experiment agree with each other well. The results show that the radius of the bypass coupling arc with or without bypass current action on the base metal is different, and the flow vector of the bypass coupling arc plasma with bypass current is larger than the arc without bypass current. By comparing the heat transfer on the electrodes’ boundary under different current conditions, it is found that increasing the bypass current results in the rise in heat input on the base metal. Therefore, it is concluded that using bypass current is unable to completely decouple the wire melting and the heat input of the base metal. The decoupled degree of heat transfer is one of the important factors for accurate control in the manufacturing process with this coupling arc