Study on induction hardening performance of 34CrNi3MoA steel crankshaft

The evolution of the temperature field, microstructure field, and residual stress field of a 34CrNi3MoA steel marine diesel engine crankshaft during medium-frequency induction hardening was studied based on an electromagnetic-thermal-transformation-stress coupled numerical model, which considers the effect of internal stress induced by transformation induced plasticity on residual stress. Using the equal conversion rate method, the austenitizing region of the crankshaft was determined during the induction heating stage. In the quenching stage, the parameters of the phase transformation model are derived from the continuous heating expansion curve and the continuous cooling transformation curve, and the phase transformation kinetics equation is used to analyze the phase transformation process of the crankshaft. The results indicate that extending the heating time can enhance the uniformity of the surface temperature of the crankshaft and the thickness of the hardened layer. The simulation results are validated by measurements of hardened layer, hardness and residual stress, and the simulation results are in good agreement with the experimental results

Oxidative balance score reflects vascular endothelial function of Chinese community dwellers

Background: The oxidative balance score (OBS) is a composite estimate of the overall pro- and antioxidant risk status in an individual. The aim of this study is to explore the association between the OBS and vascular endothelial function in Chinese community dwellers.Methods: In total, 339 community dwelling adults (aged 20–75 years) were recruited in this study. The overall OBS was calculated on the basis of 16 pro- and antioxidant factors related to diet (measured by fasting blood samples) and lifestyle (evaluated by questionnaires). The dietary OBS and lifestyle OBS were calculated on the basis of the corresponding components. Serum iso-prostaglandin F2α (FIP) was measured to evaluate the oxidative stress degree, and brachial artery blood flow-mediated dilation (FMD) was measured for vascular endothelial function. The FIP and FMD levels were dichotomized as “low” or “high” using the corresponding median values (low FIP, n = 159; high FIP, n = 180; low FMD, n = 192; and high FMD, n = 147). The components of the OBS were compared between the stratified FIP and FMD groups. Logistic regression was used to analyze the OBS associations with FIP and FMD.Results: The higher overall OBS and dietary OBS were associated with lower FIP (p < 0.001), whereas the higher overall OBS (p < 0.01) and dietary OBS (p < 0.05) were associated with higher FMD. The lifestyle OBS was not associated with FIP and FMD (p > 0.05). Except for the body mass index (BMI) and low physical activity, all other OBS components were significantly different between the low FIP and high FIP groups (p < 0.05). Four diet-related antioxidants (α-carotene, zeaxanthin, α-tocopherol, and γ-tocopherol) showed significant differences between the high and low FMD groups (p < 0.05).Conclusion: The decreasing OBS level was associated with low endothelial function and high oxidative stress. The dietary OBS, rather than the lifestyle OBS, was more closely associated with endothelial function

Suitability Assessment of Small Dams’ Location as Nature-Based Solutions to Reduce Flood Risk in Mataniko Catchment, Honiara, Solomon Islands

As global temperatures rise, flooding and storm surges caused by extreme weather threaten people’s safety and nations’ development. Nature-based Solutions (NBS) are practical actions to support resilience to reduce flood risk and are applied in many countries. As the NBS approach mentions, small check dams made of gabion and wood can retain runoff and temporarily create detention basins to reduce the magnitude of floods and provide additional water resources. However, previous dam suitability research emphasized the criteria selection and decision method evolution, which costs time on the complex calculation and does not fit the NBS small dams. This research aims to optimize the site selection workflow of small dams in vulnerable informal settlements by utilizing Remote Sensing (RS), Geographic Information Systems (GIS), and Multi-Criteria Evaluation (MCE). Several thematic layers, such as land use, river density, building distance, vegetation cover index, slope, and elevation factors, were chosen to identify the suitable area in Mataniko catchment, Honiara. More importantly, it provides a more efficient model builder that can be replicated in ArcGIS 10.8, which contributes to visualizing scenarios of the inundation area of small dams at different heights. As a result, this study tested up to 35 potential small dams with 2.5 and 5 m wall height in the flood-prone Vara Creek and selected nine small dams with 5 m height and 15 small dams at 2.5 m as the best locations according to the volume and area. Overall, it is an efficient tool for designers to communicate with different stakeholders and applies to other developing countries facing frequent floods. Moreover, it provides a prototype and evidence of NBS action to address the flood issue

Improved short-term speed prediction using spatiotemporal-vision-based deep neural network for intelligent fuel cell vehicles

In this article, an improved short-term speed prediction method is proposed to predict short-term future speed and analyze future energy consumption of intelligent fuel cell vehicles. The short-term future speed is predicted by the proposed Inflated 3-D Inception long short-term memory (LSTM) network, which takes the spatiotemporal-vision information and vehicle motion states. Specifically, the spatiotemporal-vision-based deep neural network utilizes image sequences captured by a front-facing camera as environmental information and historical speed series as motion information to improve the prediction accuracy. Then, a case study of the proposed speed prediction method, with rule-based energy management strategy to calculate future energy consumption, is presented. The simulation results show that short-term speed prediction based on the Inflated 3-D Inception LSTM network can achieve high accuracy of speed prediction in various traffic densities, as well as low prediction errors of future energy consumption including the hydrogen consumption and state-of-charge attenuation.This work was supported in part by the National Key Research and Development Program under Grant 2018YFB0105402 and Grant 2018YFB0105703, in part by the Fundamental Research Funds for the Central Universities under Grant 2019CDXYQC0003, Grant 244005202014, 2019, and Grant 2018CDXYTW0031, in part by the National Natural Science Foundation of China under Grant 51806024, in part by the Chongqing Research Program of Foundation and Advanced Technology under Grant cstc2017jcyjAX0276, and in part by the Venture and Innovation Support Program for Chongqing Overseas Returnees under Grant cx2018051

Beneficial Effects of Theaflavins on Metabolic Syndrome: From Molecular Evidence to Gut Microbiome

In recent years, many natural foods and herbs rich in phytochemicals have been proposed as health supplements for patients with metabolic syndrome (MetS). Theaflavins (TFs) are a polyphenol hydroxyl substance with the structure of diphenol ketone, and they have the potential to prevent and treat a wide range of MetS. However, the stability and bioavailability of TFs are poor. TFs have the marvelous ability to alleviate MetS through antiobesity and lipid-lowering (AMPK-FoxO3A-MnSOD, PPAR, AMPK, PI3K/Akt), hypoglycemic (IRS-1/Akt/GLUT4, Ca2+/CaMKK2-AMPK, SGLT1), and uric-acid-lowering (XO, GLUT9, OAT) effects, and the modulation of the gut microbiota (increasing beneficial gut microbiota such as Akkermansia and Prevotella). This paper summarizes and updates the bioavailability of TFs, and the available signaling pathways and molecular evidence on the functionalities of TFs against metabolic abnormalities in vitro and in vivo, representing a promising opportunity to prevent MetS in the future with the utilization of TFs

Phytochemical activators of Nrf2: a review of therapeutic strategies in diabetes

Insulin resistance (IR) is fundamental to the development of type 2 diabetes (T2D), and altered mitochondrial function and abnormal lipid distribution are closely associated with IR or T2D. Excess oxidative stress-induced mitochondrial damage leads to an imbalance in redox homeostasis, which is considered the major contributor to the progression of diabetes. A key cellular defense mechanism, namely, the nuclear factor-E2 p45-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway, plays an essential protective role in combating excess oxidative stress. A series of phytochemicals are reported to improve IR and restore mitochondrial function against excess oxidative stress by activating the Nrf2-ARE signaling pathway to maintain cellular reactive oxygen species (ROS) homeostasis. The present review focuses on key knowledge gaps in the Nrf2-ARE system targeted by phytochemicals and its correlation to diabetes both in the in vitro and in vivo models and recent achievements in human clinical trials to evaluate its efficiency and safety. In addition, we provide an overview of recent research progress in nutrigenomics, precision nutrition and the interactions occurring in gut microbiota associated with the Nrf2-ARE signaling pathway and diabetes chemoprevention by phytochemicals and finally propose a future research strategy for regulating redox and microbiota balance via the Nrf2-ARE pathway. The present review aims to help us comprehensively understand the critical chemopreventive role of the Nrf2-ARE pathway targeted by phytochemicals in diabetes

Growth and Thermal Conductivity Study of CuCr₂Se₄-CuCrSe₂ Hetero-Composite Crystals

The CuCrSe2 shows attractive physical properties, such as thermoelectric and multiferroic properties, but pure-phase CuCrSe2 crystal is still quite challenging to obtain because CuCr2Se4 can be easily precipitated from a CuCrSe2 matrix. Here, taking the advantage of this precipitation reaction, we grew a series of CuCrSe2-CuCr2Se4 hetero-composites by adjusting growth parameters and explored their thermal conductivity property. Determined by electron-diffraction, the orientation relationship between these two compounds is [001] (100) CuCrSe2‖[111] (220) CuCr2Se4. The out-of-plane thermal conductivity κ of these hetero-composites was measured by a time-domain thermo-reflectance method. Fitting experimental κ by the Boltzmann-Callaway model, we verify that interface scattering plays significant role to κ in CuCrSe2-CuCr2Se4 hetero-composites, while in a CuCrSe2-dominated hetero-composite, both interface scattering and anharmonic three-phonon interaction lead to the lowest κ therein. Our results reveal the thermal conductivity evolution in CuCr2Se4-CuCrSe2 hetero-composites

Growth and Thermal Conductivity Study of CuCr2Se4-CuCrSe2 Hetero-Composite Crystals

The CuCrSe2 shows attractive physical properties, such as thermoelectric and multiferroic properties, but pure-phase CuCrSe2 crystal is still quite challenging to obtain because CuCr2Se4 can be easily precipitated from a CuCrSe2 matrix. Here, taking the advantage of this precipitation reaction, we grew a series of CuCrSe2-CuCr2Se4 hetero-composites by adjusting growth parameters and explored their thermal conductivity property. Determined by electron-diffraction, the orientation relationship between these two compounds is [001] (100) CuCrSe2‖[111] (220) CuCr2Se4. The out-of-plane thermal conductivity κ of these hetero-composites was measured by a time-domain thermo-reflectance method. Fitting experimental κ by the Boltzmann-Callaway model, we verify that interface scattering plays significant role to κ in CuCrSe2-CuCr2Se4 hetero-composites, while in a CuCrSe2-dominated hetero-composite, both interface scattering and anharmonic three-phonon interaction lead to the lowest κ therein. Our results reveal the thermal conductivity evolution in CuCr2Se4-CuCrSe2 hetero-composites

Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention

Dihydromyricetin (DHM) is a flavonoid extracted from the leaves and stems of the edible plant Ampelopsis grossedentata that has been used for Chinese Traditional Medicine. It has attracted considerable attention from consumers due to its beneficial properties including anticancer, antioxidative, and anti-inflammatory activities. Continuous oxidative stress caused by intracellular redox imbalance can lead to chronic inflammation, which is intimately associated with the initiation, promotion, and progression of cancer. DHM is considered a potential redox regulator for chronic disease prevention, and its biological activities are abundantly evaluated by using diverse cell and animal models. However, clinical investigations are still scanty. This review summarizes the current potential chemopreventive effects of DHM, including its properties such as anticancer, antioxidative, and anti-inflammatory activities, and further discusses the underlying molecular mechanisms of DHM in cancer chemoprevention by targeting redox balance and influencing the gut microbiota

Discovery of New Triterpenoids Extracted from <i>Camellia oleifera</i> Seed Cake and the Molecular Mechanism Underlying Their Antitumor Activity

Theasaponin derivatives, which are reported to exert antitumor activity, have been widely reported to exist in edible plants, including in the seed cake of Camellia oleifera (C.), which is extensively grown in south of China. The purpose of this study was to isolate new theasaponin derivatives from C. seed cake and explore their potential antitumor activity and their underlying molecular mechanism. In the present study, we first isolated and identified four theasaponin derivatives (compounds 1, 2, 3, and 4) from the total aglycone extract of the seed cake of Camellia oleifera by utilizing a combination of pre-acid-hydrolysis treatment and activity-guided isolation. Among them, compound 1 (C1) and compound 4 (C4) are newly discovered theasaponins that have not been reported before. The structures of these two new compounds were characterized based on comprehensive 1D and 2D NMR spectroscopy and high-resolution mass spectrometry, as well as data reported in the literature. Secondly, the cytotoxicity and antitumor property of the above four purified compounds were evaluated in selected typical tumor cell lines, Huh-7, HepG2, Hela, A549, and SGC7901, and the results showed that the ED50 value of C4 ranges from 1.5 to 11.3 µM, which is comparable to that of cisplatinum (CDDP) in these five cell lines, indicating that C4 has the most powerful antitumor activity among them. Finally, a preliminary mechanistic investigation was performed to uncover the molecular mechanism underlying the antitumor property of C4, and the results suggested that C4 may trigger apoptosis through the Bcl-2/Caspase-3 and JAK2/STAT3 pathways, and stimulate cell proliferation via the NF-κB/iNOS/COX-2 pathway. Moreover, it was surprising to find that C4 can inhibit the Nrf2/HO-1 pathway, which indicates that C4 has the potency to overcome the resistance to cancer drugs. Therefore, C1 and C4 are two newly identified theasaponin derivatives with antitumor activity from the seed cake of Camellia oleifera, and C4 is a promising antitumor candidate not only for its powerful antitumor activity, but also for its ability to function as an Nrf2 inhibitor to enhance the anticancer drug sensitivity