Electroacupuncture for psychogenic erectile dysfunction: A resting-state functional magnetic resonance imaging study exploring the alteration of fractional amplitude of low frequency fluctuation

BackgroundPsychogenic erectile dysfunction (PED) can seriously affect emotional and marital wellbeing. Electroacupuncture (EA) seems an effective method for treating PED. However, the central mechanisms underlying PED and the beneficial effects of EA treatment are unclear. The purpose of this study was to explore the central mechanisms of PED and to examine the impact of EA on erectile function.MethodsWe recruited 14 PED patients and 14 matched normal controls (NCs). PED patients underwent twice rs-fMRI scans, respectively, pre- and post-treatment. The NCs only completed one rs-fMRI scan. We used the fractional amplitude of low frequency fluctuation (fALFF) to compare spontaneous neural activity between the PED patients and NCs, and to examine the differences between the pre- and post-EA treatment scans in the PED patients.ResultsScores on the IIEF5, QEQ, and SEAR improved after EA treatment. Compared with the NCs, PED patients showed increased fALFF in the right posterior cingulate cortex (PCC), right dorsolateral prefrontal cortex (DLPFC), right supplementary motor area (SMA), and left middle occipital gyrus. Most of these regions are closely implicated in sexual inhibition. The results of the correlation analysis results indicated that the fALFF of the right PCC was negatively correlated with IIEF5 scores. After treatment, fALFF values were substantially lower in the left triangular part of the inferior frontal gyrus, right DLPFC, right SMA, bilateral PCC and the orbital part of the middle frontal gyrus, and higher in the left middle temporal gyrus and left caudate nucleus. These regions mainly belong to the default mode network (DMN), executive control network and primary sensory motor network. The results of the correlation analysis indicated a positive association between the changes in IIEF5 score and changes in the fALFF value in the right PCC after EA treatment.ConclusionIn conclusion, our study highlights that PED patients have abnormal patterns of activity in the right PCC, right DLPFC, and right SMA mainly involved in the DMN, executive central network, and sensory motor network which could lead to a higher levels of sexual inhibition. EA might regulate the process of sexual inhibition to improve erection function in PED patients probably by modulating spontaneous brain activity in the DMN, executive central network, and sensory motor network

Assessing the causal relationship between genetically determined inflammatory biomarkers and low back pain risk: a bidirectional two-sample Mendelian randomization study

BackgroundObservational studies have suggested an association between inflammatory markers and low back pain (LBP), but the causal relationship between these factors remains uncertain.MethodsWe conducted a bidirectional two-sample Mendelian randomization analysis (MR) study to investigate whether there is a causal relationship between inflammatory markers and low back pain. We obtained genetic data for CRP, along with its upstream inflammatory markers IL-6, IL-8, and IL-10, as well as low back pain from publicly available genome-wide association studies (GWAS). We applied several MR methods, including inverse variance weighting, weighted median, MR-Egger, Wald Ratio, and MR-PRESSO, to test for causal relationships. Sensitivity analyses were also conducted to assess the robustness of the results.ResultsOur analyses utilizing the Inverse Variance Weighted (IVW) method, the MR-Egger method, and the weighted median method indicated that IL-6 may be associated with an increased risk of LBP (Effect Size: -0.009, 95% Confidence Interval: -0.013–0.006, p = 9.16e-08); however, in the reverse direction, there was no significant causal effect of LBP on inflammatory markers.ConclusionOur study used a Mendelian randomization approach and found that elevated IL-6 levels may reduce the risk of LBP

Prediction of Future Spatial and Temporal Evolution Trends of Reference Evapotranspiration in the Yellow River Basin, China

Reference evapotranspiration (ET0) is an integral part of the regional hydrological cycle and energy balance and is extremely sensitive to climate change. Based on temperature data from 24 global climate models (GCMs) in the Coupled Model Intercomparison Project Phase 6 (CMIP6), this study developed a multi-model ensemble based on delta statistical downscaling with multiple interpolation methods and evaluation indicators to predict the spatial and temporal evolution trends of ET0 in the Yellow River Basin (YRB) under four emission scenarios (SSP126, SSP245, SSP370, and SSP585) for the near- (2022–2040), mid- (2041–2060), and long- (2081–2100) term future. Results demonstrate that regional data generated based on delta statistical downscaling had good simulation performance for the monthly mean, maximum, and minimum temperatures in the YRB, and the developed multi-model ensemble had better simulation capability than any single model. Compared to the historical period (1901–2014), the annual ET0 showed a highly significant increase for different future emission scenarios, and the increase is faster with increasing radiative forcing. The first main cycle of ET0 change was 52, 53, 60, and 48 years for the SSP126, SSP245, SSP370, and SSP585, respectively. ET0 in the YRB had positive values for EOF1 under all four emission scenarios, responding to a spatially consistent trend across the region. Compared to the historical period, the spatial distribution of ET0 under different future emission scenarios was characterized by being larger in the west and smaller in the east. As the radiative forcing scenario increased and time extended, ET0 significantly increased, with a maximum variation of 112.91% occurring in the western part of the YRB in the long-term future under the SSP585 scenario. This study can provide insight into the water cycle patterns of watersheds and scientific decision support for relevant departments to address the challenges of climate change

Experimental Study on the Fracture Evolution Processof Rock-like Specimens Containing a Closed RoughJoint Based on 3D-Printing Technology

In order to overcome the disadvantage of traditional joint fabrication method—inability to reproduce the rough surfaces of practical rock joints—3D-printing technology was applied to restructure five kinds of rough joint according to the failure surface formed by the triaxial prepeak unloading test in this study. And uniaxial compression test was carried out on the rock-like specimens containing closed 3D-printing rough joint to study the effects of joint inclination and joint length on the mechanical properties (peak strength, peak strain, elastic modulus, and secant modulus), cracking process, and failure modes. Besides, digital image correlation (DIC) method and acoustic emission (AE) system are used to investigate the whole evolution process of strain fields and crack propagation during loading. It is found that the mechanical parameters decrease first and then go up as the joint inclination increases, while presenting a continuous downward trend with the increase of joint length. Inclination of 45° and the larger joint length bring more extensive reduction to mechanical properties of specimens. Specimens exhibit typical brittle failure characteristics. The failure mode of specimens affected by different joint inclination is tension-shear failure. And the joint scale rises; the failure mode of specimens changes from tensile failure to shear failure. Larger joint scale results in the longer prepeak fluctuation phase on axial stress-strain curves and more dispersed distribution of high-value AE counts

Study of Neutron Radiation Field at the First Radioactive ion Beam Line in Lanzhou

International audienceThe first Radioactive Ion Beam Line in Lanzhou was a projectile fragment separator located in the HIRFL. The process of production and separation of radioactive ion beams can induce a strong and complex radiation field. The neutron dose equivalent rates were measured in four positions with a 70 MeV/u ^40Ar^18+ beam. The results were compared with that simulated by the FLUKA code. New shielding walls were installed to reduce the neutron background for spectroscopy measurement in the experimental terminal. In addition, the induced radioactivity of accelerator components and corresponding residual dose rates were analyzed for the radiation safety of accelerator workers. The airborne radioactivity as well as occupational exposure due to immersion in and inhalation of activated air were also estimated. This work aims to provide a valuable experience for the radiation study in the future fragment separator HFRS at HIAF

A Multi-Timescale Integrated Operation Model for Balancing Power Generation, Ecology, and Water Supply of Reservoir Operation

In traditional ecological scheduling, a single monthly or daily model will lead to the incomplete transmission of ecological information or increase the complexity of solving problems. Therefore, a multi-timescale nested model (MTNM) is proposed. Although the MTNM can express the daily flow process of environmental flow, the quadratic nested calculation method cannot obtain the optimal solution for the daily scheduling scheme. Targeting the problem that long and short-term objectives cannot obtain the optimal solution at the same time, this paper proposes a multi-timescale integrated model (MTIM) which considers the monthly, 10-day, and daily scale. The model is applied to the Liujiaxia reservoir. The scheduling results show that, compared with the MTNM, the MTIM can better meet the multi-objective demand. In a wet year, when both models can guarantee water supply and ecological demand, the MTIM increases electricity generation by 0.91%. In a dry year, electricity generation can still be increased by 4.35% without sacrificing the ecological and water supply benefits of the lower reaches. In different typical years, the MTIM can improve the contradictory relationship between multi-objective by improving the utilization efficiency of water. The results can improve the decision support for the operation process of other reservoirs with ecological needs