Two-dimensional non-Hermitian skin effect in an ultracold Fermi gas

The concept of non-Hermiticity has expanded the understanding of band topology leading to the emergence of counter-intuitive phenomena. One example is the non-Hermitian skin effect (NHSE), which involves the concentration of eigenstates at the boundary. However, despite the potential insights that can be gained from high-dimensional non-Hermitian quantum systems in areas like curved space, high-order topological phases, and black holes, the realization of this effect in high dimensions remains unexplored. Here, we create a two-dimensional (2D) non-Hermitian topological band for ultracold fermions in spin-orbit-coupled optical lattices with tunable dissipation, and experimentally examine the spectral topology in the complex eigenenergy plane. We experimentally demonstrate pronounced nonzero spectral winding numbers when the dissipation is added to the system, which establishes the existence of 2D skin effect. We also demonstrate that a pair of exceptional points (EPs) are created in the momentum space, connected by an open-ended bulk Fermi arc, in contrast to closed loops found in Hermitian systems. The associated EPs emerge and shift with increasing dissipation, leading to the formation of the Fermi arc. Our work sets the stage for further investigation into simulating non-Hermitian physics in high dimensions and paves the way for understanding the interplay of quantum statistics with NHSE.Comment: 10 pages, 4 figures with supplementary informatio

Characterization of Bioactive Recombinant Human Lysozyme Expressed in Milk of Cloned Transgenic Cattle

BACKGROUND: There is great potential for using transgenic technology to improve the quality of cow milk and to produce biopharmaceuticals within the mammary gland. Lysozyme, a bactericidal protein that protects human infants from microbial infections, is highly expressed in human milk but is found in only trace amounts in cow milk. METHODOLOGY/PRINCIPAL FINDINGS: We have produced 17 healthy cloned cattle expressing recombinant human lysozyme using somatic cell nuclear transfer. In this study, we just focus on four transgenic cattle which were natural lactation. The expression level of the recombinant lysozyme was up to 25.96 mg/L, as measured by radioimmunoassay. Purified recombinant human lysozyme showed the same physicochemical properties, such as molecular mass and bacterial lysis, as its natural counterpart. Moreover, both recombinant and natural lysozyme had similar conditions for reactivity as well as for pH and temperature stability during in vitro simulations. The gross composition of transgenic and non-transgenic milk, including levels of lactose, total protein, total fat, and total solids were not found significant differences. CONCLUSIONS/SIGNIFICANCE: Thus, our study not only describes transgenic cattle whose milk offers the similar nutritional benefits as human milk but also reports techniques that could be further refined for production of active human lysozyme on a large scale

Preparation and biological properties of a novel composite scaffold of nano-hydroxyapatite/chitosan/carboxymethyl cellulose for bone tissue engineering

Abstract In this study, we report the physico-chemical and biological properties of a novel biodegradable composite scaffold made of nano-hydroxyapatite and natural derived polymers of chitosan and carboxymethyl cellulose, namely, n-HA/CS/CMC, which was prepared by freeze-drying method. The physico-chemical properties of n-HA/CS/CMC scaffold were tested by infrared absorption spectra (IR), transmission electron microscope(TEM), scanning electron microscope(SEM), universal material testing machine and phosphate buffer solution (PBS) soaking experiment. Besides, the biological properties were evaluated by MG63 cells and Mesenchymal stem cells (MSCs) culture experiment in vitro and a short period implantation study in vivo. The results show that the composite scaffold is mainly formed through the ionic crossing-linking of the two polyions between CS and CMC, and n-HA is incorporated into the polyelectrolyte matrix of CS-CMC without agglomeration, which endows the scaffold with good physico-chemical properties such as highly interconnected porous structure, high compressive strength and good structural stability and degradation. More important, the results of cells attached, proliferated on the scaffold indicate that the scaffold is non-toxic and has good cell biocompatibility, and the results of implantation experiment in vivo further confirm that the scaffold has good tissue biocompatibility. All the above results suggest that the novel degradable n-HA/CS/CMC composite scaffold has a great potential to be used as bone tissue engineering material.</p

The Preparation, Characterization, Mechanical and Antibacterial Properties of GO-ZnO Nanocomposites with a Poly(l-lactide)-Modified Surface

Graphene oxide (GO) was employed for the preparation of GO-zinc oxide (ZnO). The hydroxyl group on the surface was exploited to trigger the l-lactide ring-opening polymerization. A composite material with poly(l-lactide) (PLLA) chains grafted to the GO-ZnO surface, GO-ZnO-PLLA, was prepared. The results demonstrated that the employed method allowed one-step, rapid grafting of PLLA to the GO-ZnO surface. The chemical structure of the GO surface was altered by improved dispersion of GO-ZnO in organic solvents, thus enhancing the GO-ZnO dispersion in the PLLA matrix and the interface bonding with PLLA. Subsequently, composite films, GO-ZnO-PLLA and GO-ZnO-PLLA/PLLA, were prepared. The changes in interface properties and mechanical properties were studied. Furthermore, the antibacterial performance of nano-ZnO was investigated

Uniaxial Compression Creep Relaxation and Grading of Coal Samples via Tests on the Progressive Failure Characteristics

An RMT-150B electrohydraulic servo testing system was used to perform uniaxial compression and uniaxial grading relaxation (creep) tests. The deformation, strength, and failure characteristics of the progressive failure process of coal samples under three loading modes were analyzed. The analysis results show that the prepeak stress-strain curve of the coal samples and the load relationships are not clear and that the whole compression process of coal still showed compression, elastic, yielding, and failure stages. The local stress drop characteristics during our relaxation creep grading tests showed no clear peak value and showed a yield curve with the shape of a conventional single plateau. The values of the mechanical parameters of axial compression were significantly higher than those obtained in the grade relaxation (creep) tests, which showed the mechanical parameters of coal samples with aging characteristics. In the relaxation (creep) tests, when the stress ratio was less than 70%, the relaxation (creep) characteristics of the sample were not clear. When the ratio of stress relaxation (creep) was more than 70% in the relaxation (creep) tests during displacement (stress) with a constant relaxation (creep) over the duration of the test, the evolution, development, and convergence of microcracks in the coal samples were observed. Relaxation (creep) stress was higher, failure duration was shorter, and the duration of failure was longer. For fully mechanized coal faces, increasing the support resistance and timely moving the support after coal cutting may prevent rib spalling accidents by reducing coal stress and exposure time in the front of the working face. Additionally, routine uniaxial compressive failures showed a simple form, having a clear tension-shear dual rupture surface. The staged relaxation creep failure testing of coal is more complex. The entire coal samples were divided into many thin-sheet debris via gradual collapse and shedding, and the number of cracks increased significantly, showing evident lateral expansion characteristics that are similar to the rib spalling characteristics in high coal mining working faces

Experimental study on the effect of grouting reinforcement on the shear strength of a fractured rock mass.

To study the strengthening mechanism and effect underlying the reinforcement of a fractured rock mass with grouting, compressive shear tests were conducted with an RMT-150B rock mechanics test system. Prefabricated structural surfaces were strengthened with a new inorganic dual-liquid grouting material at five water-cement ratios (0.6-1.5). The effects of these water-cement ratios of the grouting on the deformation, strength, and failure characteristics of the prefabricated structural surface were analyzed. The results show that reinforcement with grouting significantly influenced the bearing capacity of the structural surface. The shear strength of the structure was significantly improved and the deformation resistance of the structural surface was enhanced. The shear stress-displacement curves, generated in compressive shear tests of the grouting-reinforced structures, were all nonlinear. The shearing process comprised three stages: elasticity, yield, and failure. Decreasing the water-cement ratio of the grouting material weakened the plasticity of the grouted structural surface and enhanced its brittleness. The deformation type changed from plastic slip to brittle shear. The shear strength, cohesion, and angle of internal friction of the grouting-reinforced structural surface increased with decreasing water-cement ratio