Simplified topological invariants for interacting insulators

We propose general topological order parameters for interacting insulators in terms of the Green's function at zero frequency. They provide an unified description of various interacting topological insulators including the quantum anomalous Hall insulators and the time reversal invariant insulators in four, three and two dimensions. Since only Green's function at zero frequency is used, these topological order parameters can be evaluated efficiently by most numerical and analytical algorithms for strongly interacting systems.Comment: Published versio

Nucleation of membrane adhesions

Recent experimental and theoretical studies of biomimetic membrane adhesions [Bruinsma et al., Phys. Rev. E 61, 4253 (2000); Boulbitch et al., Biophys. J. 81, 2743 (2001)] suggested that adhesion mediated by receptor interactions is due to the interplay between membrane undulations and a double-well adhesion potential, and should be a first-order transition. We study the nucleation of membrane adhesion by finding the minimum-energy path on the free energy surface constructed from the bending free energy of the membrane and the double-well adhesion potential. We find a nucleation free energy barrier around 20kBT for adhesion of flexible membranes, which corresponds to fast nucleation kinetics with a time scale of the order of seconds. For cell membranes with a larger bending rigidity due to the actin network, the nucleation barrier is higher and may require active processes such as the reorganization of the cortex network to overcome this barrier. Our scaling analysis suggests that the geometry of the membrane shapes of the adhesion contact is controlled by the adhesion length that is determined by the membrane rigidity, the barrier height, and the length scale of the double-well potential, while the energetics of adhesion is determined by the depths of the adhesion potential. These results are verified by numerical calculations

Systemic similarity analysis of compatibility drug-induced multiple pathway patterns _in vivo_

A major challenge in post-genomic research is to understand how physiological and pathological phenotypes arise from the networks of expressed genes and to develop powerful tools for translating the information exchanged between gene and the organ system networks. Although different expression modules may contribute independently to different phenotypes, it is difficult to interpret microarray experimental results at the level of single gene associations. The global effects and response pathways of small molecules in cells have been investigated, but the quantitative details of the activation mechanisms of multiple pathways _in vivo_ are not well understood. Similar response networks indicate similar modes of action, and gene networks may appear to be similar despite differences in the behaviour of individual gene groups. Here we establish the method for assessing global effect spectra of the complex signaling forms using Global Similarity Index (GSI) in cosines vector included angle. Our approach provides quantitative multidimensional measures of genes expression profile based on drug-dependent phenotypic alteration _in vivo_. These results make a starting point for identifying relationships between GSI at the molecular level and a step toward phenotypic outcomes at a system level to predict action of unknown compounds and any combination therapy

Waiting time distribution of solar energetic particle events modeled with a non-stationary Poisson process

We present a study of the waiting time distributions (WTDs) of solar energetic particle (SEP) events observed with the spacecraft $WIND$ and $GOES$. Both the WTDs of solar electron events (SEEs) and solar proton events (SPEs) display a power-law tail $\sim \Delta t^{-\gamma}$. The SEEs display a broken power-law WTD. The power-law index is $\gamma_{1} =$ 0.99 for the short waiting times ($$100 hours). The break of the WTD of SEEs is probably due to the modulation of the corotating interaction regions (CIRs). The power-law index $\gamma \sim$ 1.82 is derived for the WTD of SPEs that is consistent with the WTD of type II radio bursts, indicating a close relationship between the shock wave and the production of energetic protons. The WTDs of SEP events can be modeled with a non-stationary Poisson process which was proposed to understand the waiting time statistics of solar flares (Wheatland 2000; Aschwanden $\&$ McTiernan 2010). We generalize the method and find that, if the SEP event rate $\lambda = 1/\Delta t$ varies as the time distribution of event rate $f(\lambda) = A \lambda^{-\alpha}exp(-\beta \lambda)$, the time-dependent Poisson distribution can produce a power-law tail WTD $\sim \Delta t^{\alpha - 3}$, where $0 \leq \alpha < 2$.Comment: 10 pages, 4 figures, accepted for publication in ApJ Letter

Multiple scattering effects on heavy meson production in p+A collisions at backward rapidity

We study the incoherent multiple scattering effects on heavy meson production in the backward rapidity region of p+A collisions within the generalized high-twist factorization formalism. We calculate explicitly the double scattering contributions to the heavy meson differential cross sections by taking into account both initial-state and final-state interactions, and find that these corrections are positive. We further evaluate the nuclear modification factor for muons that come form the semi-leptonic decays of heavy flavor mesons. Phenomenological applications in d+Au collisions at a center-of-mass energy $\sqrt{s}=200$ GeV at RHIC and in p+Pb collisions at $\sqrt{s}=5.02$ TeV at the LHC are presented. We find that incoherent multiple scattering can describe rather well the observed nuclear enhancement in the intermediate $p_T$ region for such reactions.Comment: 10 pages, 6 figures, published version in PL