Physical modelling of amorphous thermoplastic polymer and numerical simulation of micro hot embossing process

Micro hot embossing process is considered as one of the most promising micro replication processes for manufacturing of polymeric components, especially for the high aspect ratio components and large surface structural components. A large number of hot embossing experimental results have been published, the material modelling and processes simulation to improve the quality of micro replication by hot embossing process are still lacking. This paper consists to 3D modelling of micro hot embossing process with amorphous thermoplastic polymers, including the mechanical characterisation of polymers properties, identification of the viscoelastic behaviour law of the polymers, numerical simulation and experimental investigation of micro hot embossing process. Static compression creep tests have been carried out to investigate the selected polymers’ viscoelastic properties. The Generalized Maxwell model has been proposed to describe the relaxation modulus of the polymers and good agreement has been observed. The numerical simulation of the hot embossing process in 3D has been achieved by taking into account the viscoelastic behaviour of the polymers. The microfluidic devices with the thickness of 2 mm have been elaborated by hot embossing process. The hot embossing process has been carried out using horizontal injection/compression moulding equipment, especially developed for this study. A complete compression mould tool, equipped with the heating system, the cooling system, the ejection system and the vacuum system, has been designed and elaborated in our research. Polymer-based microfluidic devices have been successfully replicated by the hot embossing process using the compression system developed. Proper agreement between the numerical simulation and the experimental elaboration has been observed. It shows strong possibility for the development of the 3D numerical model to optimize the micro hot embossing process in the future

Classification of finite irreducible modules over the Lie conformal superalgebra CK6

We classify all continuous degenerate irreducible modules over the exceptional linearly compact Lie superalgebra E(1, 6), and all finite degenerate irreducible modules over the exceptional Lie conformal superalgebra CK6, for which E(1, 6) is the annihilation algebra

Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice

Failure to express or expression of dysfunctional low-density lipoprotein receptors (LDLR) causes familial hypercholesterolemia in humans, a disease characterized by elevated blood cholesterol concentrations, xanthomas, and coronary heart disease, providing compelling evidence that high blood cholesterol concentrations cause atherosclerosis. In this study, we used 1H nuclear magnetic resonance spectroscopy to examine the metabolic profiles of plasma and urine from the LDLR knockout mice. Consistent with previous studies, these mice developed hypercholesterolemia and atherosclerosis when fed a high-fat/cholesterol/cholate-containing diet. In addition, multivariate statistical analysis of the metabolomic data highlighted significant differences in tricarboxylic acid cycle and fatty acid metabolism, as a result of high-fat/cholesterol diet feeding. Our metabolomic study also demonstrates that the effect of high-fat/cholesterol/cholate diet, LDLR gene deficiency, and the diet-genotype interaction caused a significant perturbation in choline metabolism, notably the choline oxidation pathway. Specifically, the loss in the LDLR caused a marked reduction in the urinary excretion of betaine and dimethylglycine, especially when the mice are fed a high-fat/cholesterol/cholate diet. Furthermore, as we demonstrate that these metabolic changes are comparable with those detected in ApoE knockout mice fed the same high-fat/cholesterol/cholate diet they may be useful for monitoring the onset of atherosclerosis across animal models

The Effect of Retro-Cueing on an ERP Marker of VSTM Maintenance

Previous research has found that Contralateral Delay Activity (CDA) is correlated with the number of items maintained in Visual Short Term Memory from one visual field (VF) (Vogel & Machizawa, 2004). CDA is usually elicited by a to-be-remembered array after a prospective cue (pro-cue) signalling the relevant side of the visual display, and is interpreted as a putative electrophysiological signature of WM maintenance. Attention can also be directed to the contents of VSTM, after the presentation of a visual array, using a retroactive cue (retro-cue) (Nobre, Griffin, & Rao, 2008). Because retro-cueing directs attention within a memory trace, potentially reducing the load of items to be maintained, we hypothesised that this would significantly attenuate the CDA. Participants were initially presented with a spatial pro-cue which reduced the number of to-be-remembered items to one side. After a delay, a memory array of either four (low load) or eight (high load) items was displayed. A retro-cue then cued participants to one location within the relevant VF, further reducing the load of to-be-remembered items; or provided no information, requiring participants to hold all items in the relevant VF. At the end of the trial, participants performed a same/different judgement on a test stimulus. Retro-cues significantly improved VSTM performance. Unexpectedly, the CDA was found to be abolished by the presentation of both spatially predictive and neutral cues, independently of the VSTM load participants had to maintain