Systemic similarity analysis of compatibility drug-induced multiple pathway patterns _in vivo_

A major challenge in post-genomic research is to understand how physiological and pathological phenotypes arise from the networks of expressed genes and to develop powerful tools for translating the information exchanged between gene and the organ system networks. Although different expression modules may contribute independently to different phenotypes, it is difficult to interpret microarray experimental results at the level of single gene associations. The global effects and response pathways of small molecules in cells have been investigated, but the quantitative details of the activation mechanisms of multiple pathways _in vivo_ are not well understood. Similar response networks indicate similar modes of action, and gene networks may appear to be similar despite differences in the behaviour of individual gene groups. Here we establish the method for assessing global effect spectra of the complex signaling forms using Global Similarity Index (GSI) in cosines vector included angle. Our approach provides quantitative multidimensional measures of genes expression profile based on drug-dependent phenotypic alteration _in vivo_. These results make a starting point for identifying relationships between GSI at the molecular level and a step toward phenotypic outcomes at a system level to predict action of unknown compounds and any combination therapy

Application of Knowledge-based Short Videos in University Students’ Learning: Examination and Enhancement of Motivation, Goals, Strategies, and Achievements

In today’s world of accessible knowledge education, knowledge-based short videos have become a favored learning tool for many learners. However, the effectiveness of this learning method remains unclear, and research in the field of short video learning is still in its early stages and needs further exploration. This study surveyed 202 university students and conducted case analyses on 4 students to investigate the effects of self-determined motivation, goal orientation, self-regulated learning strategies, and cognitive academic achievements in the context of learning through knowledge-based short videos. The results indicate that students who use short videos for learning demonstrate a moderate level of self-determined motivation, while their goal orientation, self-regulated learning strategies, and cognitive academic achievements require improvement. Senior students exhibited better self-determined motivation and cognitive academic achievements compared to junior students. Additionally, an increase in self-determined motivation, self-regulated learning strategies, and cognitive academic achievements was observed with increased time spent watching short videos. It was found that a moderate viewing time of about 2 hours per day is associated with certain learning benefits, while excessive viewing time may result in the opposite effect. Based on these findings, the study concludes with learning recommendations aimed at optimizing the application of short video learning tools and providing insights for future research in this area

Broad bandwidth waveguide polarizer via grating mediated mode conversion

A polarization beam splitter (PBS) based on a four-layer slab waveguide is proposed, where a sub-wavelength grating is embedded between the waveguide core and the cladding. This grating not only affords Bragg momentum to tune the propagation constant of guiding modes but also converts the forward zero-order waveguide mode to the backward first one for a specific polarization. Thus, the incident light with polarization that satisfies the phase-matching condition is highly reflected in the waveguide, while other light with orthogonal polarization keeps intact and passes through it efficiently. Numerical simulations show that one can make the compact PBS for both polarizations with an extinction ratio higher than 35 dB, a waveband larger than 80 nm, a grating period tolerance of 20 nm, and a waveguide height tolerance of 80 nm. The revealed mode conversion mechanism via the sub-wavelength grating enriches the design of PBSs for integrated silicon waveguide chips

A General Procedure for the Regioselective Synthesis of Aryl Thioethers and Aryl Selenides Through C–H Activation of Arenes

A general procedure for the synthesis of aryl thioethers and aryl selenides in one-pot through sequential iridium-catalyzed C–H borylation and copper-promoted C–S and C–Se bond formation is described. Functional groups including chloro, nitro, fluoro, trifluoromethyl, and nitrogen-containing heterocycles were all tolerated under the reaction conditions. Importantly, not only aryl thiols and selenides but also their alkyl analogs were suitable coupling partners, and the products were obtained in good yields with high meta regioselectivity

Impact of combinations of time-delay interferometry channels on stochastic gravitational wave background detection

The method of time delay interferometry (TDI) is proposed to cancel the laser noise in space-borne gravitational-wave detectors. Among all different TDI combinations, the most commonly used ones are the orthogonal channels A, E and T, where A and E are signal-sensitive and T is signal-insensitive. Meanwhile, for the detection of stochastic gravitational-wave background, one needs to introduce the overlap reduction function to characterize the correlation between channels. For the calculation of overlap reduction function, it is often convenient to work in the low-frequency approximation, and assuming the equal-arm Michelson channels. However, if one wishes to work on the overlap reduction function of $\rm A/E$ channels, then the low-frequency approximation fails. We derive the exact form of overlap reduction function for $\rm A/E$ channels. Based on the overlap reduction function, we calculate the sensitivity curves of TianQin, TianQin I+II and TianQin + LISA. We conclude that the detection sensitivity calculated with $\rm A/E$ channels is mostly consistent with that obtained from the equal-arm Michelson channels.Comment: 18 pages,10 figure