Space Net Optimization

Most metaheuristic algorithms rely on a few searched solutions to guide later searches during the convergence process for a simple reason: the limited computing resource of a computer makes it impossible to retain all the searched solutions. This also reveals that each search of most metaheuristic algorithms is just like a ballpark guess. To help address this issue, we present a novel metaheuristic algorithm called space net optimization (SNO). It is equipped with a new mechanism called space net; thus, making it possible for a metaheuristic algorithm to use most information provided by all searched solutions to depict the landscape of the solution space. With the space net, a metaheuristic algorithm is kind of like having a ``vision'' on the solution space. Simulation results show that SNO outperforms all the other metaheuristic algorithms compared in this study for a set of well-known single objective bound constrained problems in most cases.Comment: 12 pages, 6 figure

On the Momentum Dependence of the Flavor Structure of the Nucleon Sea

Difference between the $\bar u$ and $\bar d$ sea quark distributions in the proton was first observed in the violation of the Gottfried sum rule in deep-inelastic scattering (DIS) experiments. The parton momentum fraction $x$ dependence of this difference has been measured over the region $0.02 < x < 0.35$ from Drell-Yan and semi-inclusive DIS experiments. The Drell-Yan data suggested a possible sign-change for $\bar d(x)-\bar u(x)$ near $x \sim 0.3$, which has not yet been explained by existing theoretical models. We present an independent evidence for the $\bar d(x)-\bar u(x)$ sign-change at $x \sim 0.3$ from an analysis of the DIS data. We further discuss the $x$-dependence of $\bar d(x)-\bar u(x)$ in the context of meson cloud model and the lattice QCD formulation.Comment: 5 pages, 5 figures, final versio

Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice

<p>Abstract</p> <p>Background</p> <p>Mice lacking the preproenkephalin (<it>ppENK</it>) gene are hyperalgesic and show more anxiety and aggression than wild-type (WT) mice. The marked behavioral changes in <it>ppENK </it>knock-out (KO) mice appeared to occur in supraspinal response to painful stimuli. However the functional role of enkephalins in the supraspinal nociceptive processing and their underlying mechanism is not clear. The aim of present study was to compare supraspinal nociceptive and morphine antinociceptive responses between WT and <it>ppENK </it>KO mice.</p> <p>Results</p> <p>The genotypes of bred KO mice were confirmed by PCR. Met-enkephalin immunoreactive neurons were labeled in the caudate-putamen, intermediated part of lateral septum, lateral globus pallidus, intermediated part of lateral septum, hypothalamus, and amygdala of WT mice. Met-enkephalin immunoreactive neurons were not found in the same brain areas in KO mice. Tail withdrawal and von Frey test results did not differ between WT and KO mice. KO mice had shorter latency to start paw licking than WT mice in the hot plate test. The maximal percent effect of morphine treatments (5 mg/kg and 10 mg/kg, i.p.) differed between WT and KO mice in hot plate test. The current source density (CSD) profiles evoked by peripheral noxious stimuli in the primary somatosenstory cortex (S1) and anterior cingulate cortex (ACC) were similar in WT and KO mice. After morphine injection, the amplitude of the laser-evoked sink currents was decreased in S1 while the amplitude of electrical-evoked sink currents was increased in the ACC. These differential morphine effects in S1 and ACC were enhanced in KO mice. Facilitation of synaptic currents in the ACC is mediated by GABA inhibitory interneurons in the local circuitry. Percent increases in opioid receptor binding in S1 and ACC were 5.1% and 5.8%, respectively.</p> <p>Conclusion</p> <p>The present results indicate that the endogenous enkephalin system is not involved in acute nociceptive transmission in the spinal cord, S1, and ACC. However, morphine preferentially suppressed supraspinal related nociceptive behavior in KO mice. This effect was reflected in the potentiated differential effects of morphine in the S1 and ACC in KO mice. This potentiation may be due to an up-regulation of opioid receptors. Thus these findings strongly suggest an antagonistic interaction between the endogenous enkephalinergic system and exogenous opioid analgesic actions in the supraspinal brain structures.</p

The Impacts Of Presentation Modes And Product Involvements On “Line” Short Message Service (SMS) Advertising Effectiveness

In today’s ubiquitous commerce (UC) era, short message service (SMS) advertisement has played an important role in the world of marketing. Convenience and economical reasons influence SMS usage frequency along with social involvement to influence attitudes towards SMS advertising. SMS advertising creates numerous opportunities for the marketers in promoting their products effectively. Adopting the competition for attention theory as the theoretical framework, we developed hypotheses to investigate the influences of presentation mode and involvement on SMS advertising performance (recall of advertising information). An experiment was conducted to examine the effects of three types of information presentation modes (text-only, image-text, and emoji-text) in the contexts of two product types (high- versus low-involvement products) in the “LINE” SMS environment. Specifically, in this current study, we allocate participants to six experimental environments (text-only for high-involvement products, text-only for low-involvement products, image-text for high-involvement products, image-text for low-involvement products, emoji-text for high-involvement products and emoji-text for low-involvement products) randomly to collected empirical data to examine the proposed hypotheses. The research findings are expected to provide instrumental guidelines for the practitioners to better achieve the goals of ads in the “LINE” SMS environment. Also, the empirical results may provide insights into the research of advertising interface design of SMS and integrating efforts from cognitive science and vision research to understand users’ involvement of SMS advertising processes

Seismic analysis of the condensate storage tank in a nuclear power plant

Following the nuclear power plant accident in Fukushima Japan, seismic capacity evaluation has become a crucial issue in combination building safety. Condensate storage tanks are designed to supplies water to the condensate transfer pumps, the control rod drive hydraulic system pumps, and the condenser makeup. A separate connection to the condensate storage tank is used to supply water for the high pressure coolant injection system, reactor core isolation cooling system, and core spray system pumps. A condensate storage tank is defined as a seismic class I structure, playing the important role of providing flow to the operational system and the required static head for the suction of the condensate transfer pumps and the normal supply pump. According to the latest nuclear safety requirements, soil structure interaction must be considered in all seismic analyses. This study aims to rebuild the computer model of condensate storage tanks in Taiwan using the SAP 2000 program in conjunction with the lumped mass stick model and to evaluate the soil structure interaction by employing the SASSI 2000 program. The differences between the results with the soil structure interaction and spring model are compared via natural frequency and response spectrum curves. This computer model enables engineers to rapidly evaluate the safety margin of condensate storage tank following the occurrence of earthquakes or tsunamis