1,730 research outputs found
Nominal Logic Programming
Nominal logic is an extension of first-order logic which provides a simple
foundation for formalizing and reasoning about abstract syntax modulo
consistent renaming of bound names (that is, alpha-equivalence). This article
investigates logic programming based on nominal logic. We describe some typical
nominal logic programs, and develop the model-theoretic, proof-theoretic, and
operational semantics of such programs. Besides being of interest for ensuring
the correct behavior of implementations, these results provide a rigorous
foundation for techniques for analysis and reasoning about nominal logic
programs, as we illustrate via examples.Comment: 46 pages; 19 page appendix; 13 figures. Revised journal submission as
of July 23, 200
Negative thermal expansion of MgB in the superconducting state and anomalous behavior of the bulk Gr\"uneisen function
The thermal expansion coefficient of MgB is revealed to change
from positive to negative on cooling through the superconducting transition
temperature . The Gr\"uneisen function also becomes negative at
followed by a dramatic increase to large positive values at low temperature.
The results suggest anomalous coupling between superconducting electrons and
low-energy phonons.Comment: 5 figures. submitted to Phys. Rev. Let
A dependent nominal type theory
Nominal abstract syntax is an approach to representing names and binding
pioneered by Gabbay and Pitts. So far nominal techniques have mostly been
studied using classical logic or model theory, not type theory. Nominal
extensions to simple, dependent and ML-like polymorphic languages have been
studied, but decidability and normalization results have only been established
for simple nominal type theories. We present a LF-style dependent type theory
extended with name-abstraction types, prove soundness and decidability of
beta-eta-equivalence checking, discuss adequacy and canonical forms via an
example, and discuss extensions such as dependently-typed recursion and
induction principles
Quantum process tomography of molecular dimers from two-dimensional electronic spectroscopy I: General theory and application to homodimers
Is it possible to infer the time evolving quantum state of a
multichromophoric system from a sequence of two-dimensional electronic spectra
(2D-ES) as a function of waiting time? Here we provide a positive answer for a
tractable model system: a coupled dimer. After exhaustively enumerating the
Liouville pathways associated to each peak in the 2D-ES, we argue that by
judiciously combining the information from a series of experiments varying the
polarization and frequency components of the pulses, detailed information at
the amplitude level about the input and output quantum states at the waiting
time can be obtained. This possibility yields a quantum process tomography
(QPT) of the single-exciton manifold, which completely characterizes the open
quantum system dynamics through the reconstruction of the process matrix. This
is the first of a series of two articles. In this manuscript, we specialize our
results to the case of a homodimer, where we prove that signals stemming from
coherence to population transfer and viceversa vanish upon isotropic averaging,
and therefore, only a partial QPT is possible in this case. However, this fact
simplifies the spectra, and it follows that only two polarization controlled
experiments (and no pulse-shaping requirements) suffice to yield the elements
of the process matrix which survive under isotropic averaging. The angle
between the two site transition dipole moments is self-consistently obtained
from the 2D-ES. Model calculations are presented, as well as an error analysis
in terms of the angle between the dipoles and peak overlap. In the second
article accompanying this study, we numerically exemplify the theory for
heterodimers and carry out a detailed error analysis for such case. This
investigation provides an important benchmark for more complex proposals of
quantum process tomography (QPT) via multidimensional spectroscopic
experiments
Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated neuronal dysfunction.
Neuronal damage is a hallmark feature of HIV-associated neurological disorders (HANDs). Opiate drug abuse accelerates the incidence and progression of HAND; however, the mechanisms underlying the potentiation of neuropathogenesis by these drugs remain elusive. Opiates such as morphine have been shown to enhance HIV transactivation protein Tat-mediated toxicity in both human neurons and neuroblastoma cells. In the present study, we demonstrate reduced expression of the tropic factor platelet-derived growth factor (PDGF)-B with a concomitant increase in miR-29b in the basal ganglia region of the brains of morphine-dependent simian immunodeficiency virus (SIV)-infected macaques compared with the SIV-infected controls. In vitro relevance of these findings was corroborated in cultures of astrocytes exposed to morphine and HIV Tat that led to increased release of miR-29b in exosomes. Subsequent treatment of neuronal SH-SY5Y cell line with exosomes from treated astrocytes resulted in decreased expression of PDGF-B, with a concomitant decrease in viability of neurons. Furthermore, it was shown that PDGF-B was a target for miR-29b as evidenced by the fact that binding of miR-29 to the 3\u27-untranslated region of PDGF-B mRNA resulted in its translational repression in SH-SY5Y cells. Understanding the regulation of PDGF-B expression may provide insights into the development of potential therapeutic targets for neuronal loss in HIV-1-infected opiate abusers
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Mathematical practice, crowdsourcing, and social machines
The highest level of mathematics has traditionally been seen as a solitary
endeavour, to produce a proof for review and acceptance by research peers.
Mathematics is now at a remarkable inflexion point, with new technology
radically extending the power and limits of individuals. Crowdsourcing pulls
together diverse experts to solve problems; symbolic computation tackles huge
routine calculations; and computers check proofs too long and complicated for
humans to comprehend.
Mathematical practice is an emerging interdisciplinary field which draws on
philosophy and social science to understand how mathematics is produced. Online
mathematical activity provides a novel and rich source of data for empirical
investigation of mathematical practice - for example the community question
answering system {\it mathoverflow} contains around 40,000 mathematical
conversations, and {\it polymath} collaborations provide transcripts of the
process of discovering proofs. Our preliminary investigations have demonstrated
the importance of "soft" aspects such as analogy and creativity, alongside
deduction and proof, in the production of mathematics, and have given us new
ways to think about the roles of people and machines in creating new
mathematical knowledge. We discuss further investigation of these resources and
what it might reveal.
Crowdsourced mathematical activity is an example of a "social machine", a new
paradigm, identified by Berners-Lee, for viewing a combination of people and
computers as a single problem-solving entity, and the subject of major
international research endeavours. We outline a future research agenda for
mathematics social machines, a combination of people, computers, and
mathematical archives to create and apply mathematics, with the potential to
change the way people do mathematics, and to transform the reach, pace, and
impact of mathematics research.Comment: To appear, Springer LNCS, Proceedings of Conferences on Intelligent
Computer Mathematics, CICM 2013, July 2013 Bath, U
Forward electromagnetic scattering models for sea ice
Journal ArticleRecent advances in forward modeling of the electromagnetic scattering properties of sea ice are presented. In particular, the principal results include the following: 1) approximate calculations of electromagnetic scattering from multilayer random media with rough interfaces, based on the distorted Born approximation and radiative transfer (RT) theory; 2) comprehensive theory of the effective complex permittivity of sea ice based on rigorous bounds in the quasi-static case and strong fluctuation theory in the weakly scattering regime; 3) rigorous analysis of the Helmholtz equation and its solutions for idealized sea ice models, which has led in the one dimensional (1-D) case to nonlinear generalizations of classical theorems in Fourier analysis
Orbital Symmetry of Ba(Fe1-xCox)2As2 Superconductors Probed with X-ray Absorption Spectroscopy
The orbital symmetries of electron doped iron-arsenide superconductors
Ba(Fe1-xCox)2As2 have been measured with x-ray absorption spectroscopy. The
data reveal signatures of Fe d electron itinerancy, weak electronic
correlations, and a high degree of Fe-As hybridization related to the bonding
topology of the Fe dxz+yz states, which are found to contribute substantially
at the Fermi level. The energies and detailed orbital character of Fe and As
derived unoccupied s and d states are found to be in remarkably good agreement
with the predictions of standard density functional theory.Comment: Accepted for publication in Phys. Rev. B, 3 figures. Minor
corrections adde
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