Can Electric Field Induced Energy Gaps In Metallic Carbon Nanotubes?

The low-energy electronic structure of metallic single-walled carbon nanotube (SWNT) in an external electric field perpendicular to the tube axis is investigated. Based on tight-binding approximation, a field-induced energy gap is found in all (n, n) SWNTs, and the gap shows strong dependence on the electric field and the size of the tubes. We numerically find a universal scaling that the gap is a function of the electric field and the radius of SWNTs, and the results are testified by the second-order perturbation theory in weak field limit. Our calculation shows the field required to induce a 0.1 ${\rm eV}$ gap in metallic SWNTs can be easily reached under the current experimental conditions. It indicates a kind of possibility to apply nanotubes to electric signal-controlled nanoscale switching devices

Analyzing Single-Molecule Protein Transportation Experiments via Hierarchical Hidden Markov Models

To maintain proper cellular functions, over 50% of proteins encoded in the genome need to be transported to cellular membranes. The molecular mechanism behind such a process, often referred to as protein targeting, is not well understood. Single-molecule experiments are designed to unveil the detailed mechanisms and reveal the functions of different molecular machineries involved in the process. The experimental data consist of hundreds of stochastic time traces from the fluorescence recordings of the experimental system. We introduce a Bayesian hierarchical model on top of hidden Markov models (HMMs) to analyze these data and use the statistical results to answer the biological questions. In addition to resolving the biological puzzles and delineating the regulating roles of different molecular complexes, our statistical results enable us to propose a more detailed mechanism for the late stages of the protein targeting process

Renovascular adaptive changes in chronic hypoxic polycythemia

Renovascular adaptive changes in chronic hypoxic polycythemia.BackgroundChronic hypoxia in rats produces polycythemia, and the plasma fraction falls, reducing renal plasma flow (RPF) relative to renal blood flow (RBF). Polycythemia also causes increased blood viscosity, which tends to reduce RBF and renal oxygen delivery. We studied how renal regulation of electrolyte balance and renal tissue oxygenation (which is crucial for erythropoietin regulation) are maintained in rats during hypoxic exposure.MethodsRats of two strains with differing polycythemic responses, with surgically implanted catheters in the urinary bladder, femoral artery, and left renal and right external jugular veins, were exposed to a simulated high altitude (0.5 atm) for 0, 1, 3, 14, and 30days, after which RPF (para-aminohippurate clearance), glomerular filtration rate (GFR, polyfructosan clearance), hematocrit and blood gases were measured, and RBF, renal vascular resistance and hindrance (resistance/viscosity), renal oxygen delivery, and renal oxygen consumption were calculated.ResultsDuring chronic hypoxia RBF increased, but RPF decreased because of the polycythemia. GFR remained normal because the filtration fraction (FF) increased. Renal vascular resistance decreased, and renal vascular hindrance decreased more markedly. Renal oxygen delivery and consumption both increased.ConclusionsDuring chronic hypoxia GFR homeostasis apparently took precedence over RBF autoregulation. The large decrease in renal vascular hindrance suggested that renal vascular remodeling contributes to GFR regulation. The reduced hindrance also prevented a vicious cycle of increasing polycythemia and blood viscosity, decreasing RBF, and increasing renal hypoxia and erythropoietin release

Analyzing Single-Molecule Protein Transportation Experiments via Hierarchical Hidden Markov Models

To maintain proper cellular functions, over 50% of proteins encoded in the genome need to be transported to cellular membranes. The molecular mechanism behind such a process, often referred to as protein targeting, is not well understood. Single-molecule experiments are designed to unveil the detailed mechanisms and reveal the functions of different molecular machineries involved in the process. The experimental data consist of hundreds of stochastic time traces from the fluorescence recordings of the experimental system. We introduce a Bayesian hierarchical model on top of hidden Markov models (HMMs) to analyze these data and use the statistical results to answer the biological questions. In addition to resolving the biological puzzles and delineating the regulating roles of different molecular complexes, our statistical results enable us to propose a more detailed mechanism for the late stages of the protein targeting process

The Development of a Skin Image Analysis Tool by Using Machine Learning Algorithms

We present our latest research work on the development of a skin image analysis tool by using machine-learning algorithms. Skin imaging is very import in skin research. Over the years, we have used and developed different types of skin imaging techniques. As the number of skin images and the type of skin images increase, there is a need of a dedicated skin image analysis tool. In this paper, we report the development of such software tool by using the latest MATLAB App Designer. It is simple, user friendly and yet powerful. We intend to make it available on GitHub, so that others can benefit from the software. This is an ongoing project; we are reporting here what we have achieved so far, and more functions will be added to the software in the future

Scaled outdoor experimental studies of urban thermal environment in street canyon models with various aspect ratios and thermal storage

Street aspect ratios and urban thermal storage largely determine the thermal environment in cities. By performing scaled outdoor measurements in summer of 2017 in Guangzhou, China, we investigate these impacts on spatial/temporal characteristics of urban thermal environment which are still unclear so far. Two types of street canyon models are investigated, i.e. the ‘hollow’ model resembling hollow concrete buildings and the ‘sand’ model consisting of buildings filled with sand attaining much greater thermal storage. For each model, three street aspect ratios (building height/street width, H/W = 1, 2, 3; H = 1.2 m) are considered. The diurnal variations of air-wall surface temperatures are observed and their characteristics are quantified for various cases. The daily average temperature and daily temperature range (DTR) of wall temperature vary significantly with different aspect ratios and thermal storage. During the daytime, wider street canyon (H/W = 1) with less shading area experiences higher temperature than narrower ones (H/W = 2, 3) as more solar radiation received by wall surfaces. At night, wider street canyon cools down quicker due to stronger upward longwave radiation and night ventilation. For hollow models, H/W = 1 attains DTR of 12.1 °C, which is 1.2 and 2.1 °C larger than that of H/W = 2, 3. Moreover, the sand models experience smaller DTR and a less changing rate of wall temperature than hollow models because larger thermal storage absorbs more heat in the daytime and releases more at night. DTR of hollow models with H/W = 1, 2, 3 is 4.5, 4.6 and 3.8 °C greater than sand models respectively. For both hollow and sand models, wider streets experience a little higher daily average temperature (0.3–0.6 °C) than narrower ones. Our study provides direct evidence in how man-made urban structures influence urban climate and also suggests the possibility to control outdoor thermal environment by optimize urban morphology and thermal storage

Coiling Instabilities in Multilamellar Tubes

Myelin figures are densely packed stacks of coaxial cylindrical bilayers that are unstable to the formation of coils or double helices. These myelin figures appear to have no intrinsic chirality. We show that such cylindrical membrane stacks can develop an instability when they acquire a spontaneous curvature or when the equilibrium distance between membranes is decreased. This instability breaks the chiral symmetry of the stack and may result in coiling. A unilamellar cylindrical vesicle, on the other hand, will develop an axisymmetric instability, possibly related to the pearling instability.Comment: 6 pages, 2 figure