FIELD MEASUREMENT AND NUMERICAL STUDY OF EXTERNAL WIND PRESSURE OF RIBBED COOLING TOWER

The hyperbolic thin-shell cooling tower is a typical wind-sensitive structure. The full-size measurement is the most direct and important way to study the distribution of wind pressure on the surface of the cooling tower. Due to the limitations of engineering conditions and meteorological conditions, the field measured data are relatively lacking, and the field test data of ribbed cooling towers are less. In order to analyze the wind pressure distribution on the surface of the cooling tower, we chose a ribbed cooling tower in Toksun County, Xinjiang, China, where there are strong winds all year round, and field measurements were carried out to understand the wind load characteristics of the tower under the perennial dominant wind direction and the maximum wind direction. It was found that the absolute value of the negative pressure on the leeward side was larger than that in the code and the fluctuating wind pressure coefficient fluctuates greatly when the field measured wind speed was greater than 10m/s (15 meters above the ground). For circular section cooling tower, the Reynolds number (Re) has great influence on wind pressure. With the increase of Re, the absolute value of the average negative pressure of the tail wind pressure coefficient increases, which should be paid attention to in design. The regression curves of the average wind pressure coefficients measured on site under several typical working conditions are given by using the least square method, and its form is consistent with the standard (but the coefficients are different). In addition, Fluent software was used to calculate the external wind pressure of the cooling tower, and the field measured results were compared with the Chinese code, German code and numerical calculation, and the results were consistent

GPUSCAN++^{++}:Efficient Structural Graph Clustering on GPUs

Structural clustering is one of the most popular graph clustering methods, which has achieved great performance improvement by utilizing GPUs. Even though, the state-of-the-art GPU-based structural clustering algorithm, GPUSCAN, still suffers from efficiency issues since lots of extra costs are introduced for parallelization. Moreover, GPUSCAN assumes that the graph is resident in the GPU memory. However, the GPU memory capacity is limited currently while many real-world graphs are big and cannot fit in the GPU memory, which makes GPUSCAN unable to handle large graphs. Motivated by this, we present a new GPU-based structural clustering algorithm, GPUSCAN++, in this paper. To address the efficiency issue, we propose a new progressive clustering method tailored for GPUs that not only avoid high parallelization costs but also fully exploits the computing resources of GPUs. To address the GPU memory limitation issue, we propose a partition-based algorithm for structural clustering that can process large graphs with limited GPU memory. We conduct experiments on real graphs, and the experimental results demonstrate that our algorithm can achieve up to 168 times speedup compared with the state-of-the-art GPU-based algorithm when the graph can be resident in the GPU memory. Moreover, our algorithm is scalable to handle large graphs. As an example, our algorithm can finish the structural clustering on a graph with 1.8 billion edges using less than 2 GB GPU memory

Doxycycline Regulated Induction of AKT in Murine Prostate Drives Proliferation Independently of p27 Cyclin Dependent Kinase Inhibitor Downregulation

The PI3 kinase/AKT pathway has been shown to increase degradation of the p27 cyclin dependent kinase inhibitor through phosphorylation of consensus AKT sites on p27 and SKP2, and AKT driven proliferation may be checked by feedback mechanisms that increase p27 expression and induce senescence. However, these AKT sites are not conserved in mouse, and it has not been clear whether AKT negatively regulates murine p27. Transgenic mice with a probasin promoter controlled prostate specific reverse tetracycline transactivator (ARR2Pb-rtTA) were generated and used to achieve doxycycline inducible expression of a tetracycline operon regulated constitutively active myristoylated AKT1 transgene (tetO-myrAKT). Doxycycline induction of myrAKT occurred within 1 day and rapidly induced proliferation (within 4 days) and the development of prostatic intraepithelial neoplasia (PIN) lesions in ventral prostate, which did not progress to prostate cancer. Cells in these lesions expressed high levels of p27, had increased proliferation, and there was apoptosis of centrally located cells. Doxycycline withdrawal resulted in apoptosis of cells throughout the lesions and rapid clearing of hyperplastic glands, confirming in vivo the critical antiapoptotic functions of AKT. Significantly, analyses of prostates immediately after initiating doxycycline treatment further showed that p27 expression was rapidly increased, coincident with the induction of myrAKT and prior to the development of hyperplasia and PIN. These findings establish in vivo that murine p27 is not negatively regulated by AKT and indicate that proliferation in PI3 kinase/AKT pathway driven mouse models is mediated by p27 independent mechanisms that may be distinct from those in human. Further studies using prostate specific doxycycline regulated transgene expression may be useful to assess the acute effects of inducing additional transgenes in adult murine prostate epithelium, and to assess the requirements for continued transgene expression in transgene induced tumors