INFLUENCE OF ARCH SUPPORT INSOLE ON PEOPLE WITH FLATFOOT DURING UPHILL AND DOWNHILL WALKING

The purpose of this study was to investigate the effect of the arch support insole for people with flatfoot during uphill and downhill walking. Sixteen healthy collegiate students with flatfoot were recruited in this study. The heart rate, V02max, and median frequency of surface EMG were recorded and analyzed in this study. Non-parametric Wilcoxon signed-rank test was used for statistics. The derived main results were outlined as follows: (a) V02max had significantly decreased in arch support insole compare to flat foot insole during uphill and downhill walking; (b) arch support insole could reduce the fatigue of rectus femoris muscle during downhill walking which might be associated with the decreased V02max. The integrated research results could effectively be applied to the measurement of muscle fatigue

THE INFLUENCE OF ARCH SUPPORT INSOLE ON BASKETBALL JUMP SHOT

The purpose of this investigation was to examine the effects of arch support insole on jump shot scored percentage and kinetics. Eleven females Division I basketball participated in this study. They performed the jump shots until 5 shots were scored in arch support insoles and flat insoles. Kinematic data were collected with a motion analysis system (Motion Analysis Corporation, Santa Rosa, CA, USA) at 200-Hz sampling rate. Kinetic data were collected with two AMTl force platforms (AMTI Inc., Watertown, MA, USA) at 2000-Hz sampling rate. Non-parametric Wilcoxon signed-rank test was used to compare differences between arch support insole and flat insole on variables. No difference was found on jump shot scored percentage, jump height, peak ground reaction force, time to peak force and rate of force development. Wearing arch supporting insole did not influence the jump shot scored percentage and kinetics during jump shot

EFFECT OF ARCH SUPPORT FOOT ORTHOSIS ON LOWER WTREMIN LOADING AND KINEMATICS DURING THE REBOUND

The purpose of this study was to determine whether arch support foot orthosis was capable of altering lower extremity loading and kinematics during the rebound. Nineteen female Division I basketball players participated in this study. Utilizing a repeated measures design, participants completed two rebound tasks with and without the arch support foot orthosis. Results showed that the selected arch support foot orthosis significantly decreased the peak impact force, knee internal rotation and foot inversion angle at the initial contact of the ground compared to those of the flat insole. It suggested that the use of the arch support foot orthosis can decrease the lower extremity loading and further decrease the risk of ACL injury in female basketball players

A new approach to cure and reinforce cold-cured acrylics

Purpose: The low degree of polymerization of cold-cured acrylics has resulted in inferior mechanical properties and fracture vulnerability in orthodontics removable appliances. Methods: In this study, the effect of reinforcement by various concentrations of chopped E-glass fibers (0%, 1%, 2%, 3% and 5% by weight of resin powder) and post-curing microwave irradiation (800 W for 3 min) on the flexural strength of cold-cured acrylics was evaluated at various storage conditions (at room temperature for 1 day and 7 days; at water storage for 7, 14 and 30 days). Results: The data was analyzed by using 1-way and 2-way ANOVA, and a Tukey post hoc test (α = .05). The specimens with chopped E-glass fibers treated with post-curing microwave irradiation significantly increased the flexural strength of cold-cured PMMA. The optimal concentration might be 2% fibers under irradiation. Conclusions: The exhibited reinforcement effect lasted in a consistent trend for 14 days in water storage. A new fiber-acrylic mixing method was also developed. © 2012 The Author(s).published_or_final_versio

How Arch Support Insoles Help Persons with Flatfoot on Uphill and Downhill Walking

The main purpose of this study was to investigate the effect of arch support insoles on uphill and downhill walking of persons with flatfoot. Sixteen healthy college students with flatfoot were recruited in this study. Their heart rate, peak oxygen uptake (VO2), and median frequency (MDF) of surface electromyogram were recorded and analyzed. Nonparametric Wilcoxon signed-rank test was used for statistical analysis. The main results were as follows: (a) peak VO2 significantly decreased with arch support insoles compared with flat insoles during uphill and downhill walking (arch support insole versus flat insole: uphill walking, 20.7 ± 3.6 versus 31.6 ± 5.5; downhill walking, 10.9 ± 2.3 versus 16.9 ± 4.2); (b) arch support insoles could reduce the fatigue of the rectus femoris muscle during downhill walking (MDF slope of arch support insole: 0.03 ± 1.17, flat insole: −6.56 ± 23.07); (c) insole hardness would increase not only the physical sensory input but also the fatigue of lower-limb muscles particularly for the rectus femoris muscle (MDF slope of arch support insole: −1.90 ± 1.60, flat insole: −0.83 ± 1.10) in persons with flatfoot during uphill walking. The research results show that arch support insoles could effectively be applied to persons with flatfoot to aid them during uphill and downhill walking

How arch support insoles help persons with flatfoot on uphill and downhill walking

[[abstract]]The main purpose of this study was to investigate the effect of arch support insoles on uphill and downhill walking of persons with flatfoot. Sixteen healthy college students with flatfoot were recruited in this study. Their heart rate, peak oxygen uptake (VO2), and median frequency (MDF) of surface electromyogram were recorded and analyzed. Nonparametric Wilcoxon signed-rank test was used for statistical analysis. The main results were as follows: (a) peak VO2 significantly decreased with arch support insoles compared with flat insoles during uphill and downhill walking (arch support insole versus flat insole: uphill walking, 20.7 ± 3.6 versus 31.6 ± 5.5; downhill walking, 10.9 ± 2.3 versus 16.9 ± 4.2); (b) arch support insoles could reduce the fatigue of the rectus femoris muscle during downhill walking (MDF slope of arch support insole: 0.03 ± 1.17, flat insole: −6.56 ± 23.07); (c) insole hardness would increase not only the physical sensory input but also the fatigue of lower-limb muscles particularly for the rectus femoris muscle (MDF slope of arch support insole: −1.90 ± 1.60, flat insole: −0.83 ± 1.10) in persons with flatfoot during uphill walking. The research results show that arch support insoles could effectively be applied to persons with flatfoot to aid them during uphill and downhill walking

SaeR as a Novel Target for Antivirulence Therapy against Staphylococcus aureus

ABSTRACT:Staphylococcus aureus is a major human pathogen responsible for a wide range of clinical infections. SaeRS is one of the two-component systems in S. aureus that modulate multiple virulence factors. Although SaeR is required for S. aureus to develop an infection, inhibitors have not been reported. Using an in vivo knockdown method, we demonstrated that SaeR is targetable for the discovery of antivirulence agent. HR3744 was discovered through a high-throughput screening utilising a GFP-Lux dual reporter system driven by saeP1 promoter. ,. The antivirulence efficacy of HR3744 was tested using Western blot, Quantitative Polymerase Chain Reaction, leucotoxicity, and hemolysis tests. In electrophoresis mobility shift assay, HR3744 inhibited SaeR-DNA probe binding. WaterLOGSY-NMR test showed HR3744 directly interacted with SaeR's DNA-binding domain When saeR was deleted, HR3744 lost its antivirulence property, validating the target specificity. Virtual docking and mutagenesis were used to confirm the target's specificity. When Glu159 was changed to Asn, the bacteria developed resistance to HR3744. A structure-activity relationship study revealed that a molecule with a slight modification did not inhibit SaeR, indicating the selectivity of HR3744. Interestingly, we found that SAV13, an analogue of HR3744, was four-times more potent than the HR3744 and demonstrated identical antivirulence property and target specificity. In a mouse bacteraemia model, both HR3744 and SAV13 exhibited in vivo effectiveness. Collectively, we identified the first SaeR inhibitor, which exhibited in vitro and in vivo antivirulence property, and proved that SaeR could be a novel target for developing antivirulence drugs against S. aureus infections