7,302 research outputs found
Ion-mediated RNA structural collapse: effect of spatial confinement
RNAs are negatively charged molecules residing in macromolecular crowding
cellular environments. Macromolecular confinement can influence the ion effects
in RNA folding. In this work, using the recently developed tightly bound ion
model for ion fluctuation and correlation, we investigate the confinement
effect on the ion-mediated RNA structural collapse for a simple model system.
We found that, for both Na and Mg, ion efficiencies in mediating
structural collapse/folding are significantly enhanced by the structural
confinement. Such an enhancement in the ion efficiency is attributed to the
decreased electrostatic free energy difference between the compact conformation
ensemble and the (restricted) extended conformation ensemble due to the spatial
restriction.Comment: 22 pages, 5 figure
Hyperspectral and Multispectral Image Fusion Using the Conditional Denoising Diffusion Probabilistic Model
Hyperspectral images (HSI) have a large amount of spectral information
reflecting the characteristics of matter, while their spatial resolution is low
due to the limitations of imaging technology. Complementary to this are
multispectral images (MSI), e.g., RGB images, with high spatial resolution but
insufficient spectral bands. Hyperspectral and multispectral image fusion is a
technique for acquiring ideal images that have both high spatial and high
spectral resolution cost-effectively. Many existing HSI and MSI fusion
algorithms rely on known imaging degradation models, which are often not
available in practice. In this paper, we propose a deep fusion method based on
the conditional denoising diffusion probabilistic model, called DDPM-Fus.
Specifically, the DDPM-Fus contains the forward diffusion process which
gradually adds Gaussian noise to the high spatial resolution HSI (HrHSI) and
another reverse denoising process which learns to predict the desired HrHSI
from its noisy version conditioning on the corresponding high spatial
resolution MSI (HrMSI) and low spatial resolution HSI (LrHSI). Once the
training is completes, the proposed DDPM-Fus implements the reverse process on
the test HrMSI and LrHSI to generate the fused HrHSI. Experiments conducted on
one indoor and two remote sensing datasets show the superiority of the proposed
model when compared with other advanced deep learningbased fusion methods. The
codes of this work will be opensourced at this address:
https://github.com/shuaikaishi/DDPMFus for reproducibility
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