Research on the Assessment Method of Bilingual Management Accounting Course for the Development Strategy of “New Economic Management”

The proposed strategic goal of “new economic management” is the inevitable trend of higher financial education to conform to the development of education reform. In recent years, many domestic institutions of higher learning have signed cooperative education agreements with foreign institutions. The courses of Chinese-foreign cooperative education are generally bilingual teaching mode. Bilingual course teaching under the mode of Chinese-foreign cooperative education is an important way to train high-quality international professionals, and bilingual course assessment is an essential part of the teaching process. It is the main method to evaluate teaching objectives, implement teaching evaluation and obtain teaching feedback information. At present, bilingual courses in Chinese-foreign cooperative education lack eff ective assessment methods, assessment objectives are not clear, and assessment evaluation is just a formality. Therefore, this paper takes bilingual courses in management accounting as an example to explore and think about the assessment reform of professional courses in Chinese-foreign cooperative education mode under the development strategy of “new economic management

Gapped spin liquid with Z2\mathbb{Z}_2-topological order for kagome Heisenberg model

We apply symmetric tensor network state (TNS) to study the nearest neighbor spin-1/2 antiferromagnetic Heisenberg model on Kagome lattice. Our method keeps track of the global and gauge symmetries in TNS update procedure and in tensor renormalization group (TRG) calculation. We also introduce a very sensitive probe for the gap of the ground state -- the modular matrices, which can also determine the topological order if the ground state is gapped. We find that the ground state of Heisenberg model on Kagome lattice is a gapped spin liquid with the $\mathbb{Z}_2$-topological order (or toric code type), which has a long correlation length $\xi\sim 10$ unit cell length. We justify that the TRG method can handle very large systems with over thousands of spins. Such a long $\xi$ explains the gapless behaviors observed in simulations on smaller systems with less than 300 spins or shorter than 10 unit cell length. We also discuss experimental implications of the topological excitations encoded in our symmetric tensors.Comment: 10 pages, 7 figure

Isolation and Identification of Acholeplasma sp. from the Mud Crab, Scylla serrata

For the first time, a mollicute-like organism (MLO) was cultured from moribund mud crabs (Scylla serrata) during an outbreak of clearwater disease in Zhejiang Province, China. The MLO displayed a fried-egg colony morphology in culture, did not possess a cell wall, and was not retained by 0.45 μm and 0.2 μm filters. It was able to ferment glucose, sucrose, lactose, and maltose, but it did not utilize arginine and urea. The MLO grew in the absence of bovine serum and was not susceptible to digitonin. Sequence analysis of the 16S rRNA gene revealed that this MLO had 99% identity with Acholeplasma laidlawii PG-8A, which indicates that the organism isolated from mud crabs is a member of the genus Acholeplasma

SR140333 counteracts NK-1 mediated cell proliferation in human breast cancer cell line T47D

<p>Abstract</p> <p>Background</p> <p>It has been demonstrated that certain NK-1 antagonists could reduce proliferation of several cancer cell lines, however, it is unknown whether SR140333 exerts proliferation inhibition in breast cancer cell line.</p> <p>Methods</p> <p>Immunohistochemical staining was carried out to investigate the immunolocation of NK-1 in breast cancer tissues and T47D cell line, thereafter, various concentrations of [Sar9, Met(O2)11]substance P and SR140333 were applied alone or combined. MTT assay was applied to detect cytoactivation and coulter counter was to detect growth curve. The Hoechst33258 staining was performed to detect apoptosis.</p> <p>Results</p> <p>We found that breast cancer and T47D cells bear positive expression of NK-1. SR140333 inhibited cell growth in a dose dependent manner. Furthermore, SR140333 could counteract [Sar9, Met(O2)11]substance P induced proliferation. Hoechst33258 staining revealed the presence of apoptosis after SR140333 treatment.</p> <p>Conclusions</p> <p>Our study demonstrated SR140333 exert proliferation inhibition in breast cancer cell line T47D and indicates NK-1 play a central role in the substance P related cell proliferation in breast cancer.</p

Cytoplasmic p21 induced by p65 prevents doxorubicin-induced cell death in pancreatic carcinoma cell line

<p>Abstract</p> <p>Background</p> <p>Studies have shown the existence of p21 induction in a p53-dependent and -independent pathway. Our previous study indicates that DOX-induced p65 is able to bind the p21 promoter to activate its transactivation in the cells.</p> <p>Methods</p> <p>Over-expression and knock-down experiments were performed in Human Pancreatic Carcinoma (PANC1) cells. Cell cycle and cell death related proteins were assessed by Western Blotting. Cytotoxicity assay was checked by CCK-8 kit. Cell growth was analyzed by flow cytometers.</p> <p>Results</p> <p>Here we showed that over-expression of p65 decreased the cytotoxic effect of DOX on PANC1 cells, correlating with increased induction of cytoplasmic p21. We observed that pro-caspase-3 physically associated with cytoplasmic p21, which may be contribution to prevent p21 translocation into the nucleus. Our data also suggested that no clear elevation of nuclear p21 by p65 provides a survival advantage by progression cell cycle after treatment of DOX. Likewise, down-regulation of p65 expression enhanced the cytotoxic effect of DOX, due to a significant decrease of mRNA levels of anti-apoptotic genes, such as the cellular inhibitor of apoptosis-1 (c-IAP1), and the long isoform of B cell leukemia/lymphoma-2 (Bcl-2), leading to efficient induction of caspase-3 cleavage in the cells. More, we present evidence that over-expression of p53 or p53/p65 in the PANC1 cells were more sensitive to DOX treatment, correlated with activation of caspase-3 and clear elevation of nuclear p21 level. Our previous data suggested that expression of p21 increases Gefitinib-induced cell death by blocking the cell cycle at the G1 and G2 phases. The present findings here reinforced this idea by showing p21's ability of potentiality of DOX-induced cell death correlated with its inhibition of cell cycle progression after over-expression of p53 or p53/p65.</p> <p>Conclusion</p> <p>Our data suggested p65 could increase p53-mediated cell death in response to DOX in PANC1 cells. Thus, it is worth noting that in p53 null or defective tumors, targeting in down-regulation of p65 may well be useful, leading to the potentiality of chemotherapeutic drugs.</p