Risk factors for subsidence in anterior cervical fusion with stand-alone polyetheretherketone (PEEK) cages: a review of 82 cases and 182 levels

INTRODUCTION: To determine risk factors for subsidence in patients treated with anterior cervical discectomy and fusion (ACDF) and stand-alone polyetheretherketone (PEEK) cages. MATERIALS AND METHODS: Records of patients with degenerative spondylosis or traumatic disc herniation resulting in radiculopathy or myelopathy between C2 and C7 who underwent ACDF with stand-alone PEEK cages were retrospectively reviewed. Cages were filled with autogenous cancellous bone harvested from iliac crest or hydroxyapatite. Subsidence was defined as a decrease of 3 mm or more of anterior or posterior disc height from that measured on the postoperative radiograph. Eighty-two patients (32 males, 50 females; 182 treatment levels) were included in the analysis. RESULTS: Most patients had 1–2 treatment levels (62.2 %), and 37.8 % had 3–4 treatment levels. Treatment levels were from C2–7. Of the 82 patients, cage subsidence occurred in 31 patients, and at 39 treatment levels. Multivariable analysis showed that subsidence was more likely to occur in patients with more than two treatment levels, and more likely to occur at treatment levels C5–7 than at levels C2–5. Subsidence was not associated with postoperative alignment change but associated with more disc height change (relatively oversized cage). CONCLUSION: Subsidence is associated with a greater number of treatment levels, treatment at C5–7 and relatively oversized cage use

INFLUENCE OF ARCH SUPPORT INSOLE ON PEOPLE WITH FLATFOOT DURING UPHILL AND DOWNHILL WALKING

The purpose of this study was to investigate the effect of the arch support insole for people with flatfoot during uphill and downhill walking. Sixteen healthy collegiate students with flatfoot were recruited in this study. The heart rate, V02max, and median frequency of surface EMG were recorded and analyzed in this study. Non-parametric Wilcoxon signed-rank test was used for statistics. The derived main results were outlined as follows: (a) V02max had significantly decreased in arch support insole compare to flat foot insole during uphill and downhill walking; (b) arch support insole could reduce the fatigue of rectus femoris muscle during downhill walking which might be associated with the decreased V02max. The integrated research results could effectively be applied to the measurement of muscle fatigue

INFLUENCE OF APPROACH SPEED AND DISTANCE ON BIOMECHANICS DURING SINGLE-LEGGED RUNNING VERTICAL JUMP

The purpose of this study was to look into the kinematics, kinetics and EMG of the single legged running vertical jumps in different approach speed and distance. 12 basketball player performed single-legged running vertical jumps with 2 approach speed and 3 distance randomly. Kinematic and Kinetic data were collected by a force and 11 infrared high speed cameras. EMG data were recorded by Delsys surface EMG system. Two-way repeated measures AMOVA (2 speeds x 3 distance) was used for establishing differences (significance level p< .05). The jump height, jumt moment of lower extremity, knee power and the activation of tibialis anterior and gastrocnemius were found significantly larger in fast approach speed. We suggested using fast approach speed and 9m approach distance to enhance the single-legged running vertical jump ability

EFFECT OF ARCH SUPPORT FOOT ORTHOSIS ON LOWER WTREMIN LOADING AND KINEMATICS DURING THE REBOUND

The purpose of this study was to determine whether arch support foot orthosis was capable of altering lower extremity loading and kinematics during the rebound. Nineteen female Division I basketball players participated in this study. Utilizing a repeated measures design, participants completed two rebound tasks with and without the arch support foot orthosis. Results showed that the selected arch support foot orthosis significantly decreased the peak impact force, knee internal rotation and foot inversion angle at the initial contact of the ground compared to those of the flat insole. It suggested that the use of the arch support foot orthosis can decrease the lower extremity loading and further decrease the risk of ACL injury in female basketball players

THE INFLUENCE OF ARCH SUPPORT INSOLE ON BASKETBALL JUMP SHOT

The purpose of this investigation was to examine the effects of arch support insole on jump shot scored percentage and kinetics. Eleven females Division I basketball participated in this study. They performed the jump shots until 5 shots were scored in arch support insoles and flat insoles. Kinematic data were collected with a motion analysis system (Motion Analysis Corporation, Santa Rosa, CA, USA) at 200-Hz sampling rate. Kinetic data were collected with two AMTl force platforms (AMTI Inc., Watertown, MA, USA) at 2000-Hz sampling rate. Non-parametric Wilcoxon signed-rank test was used to compare differences between arch support insole and flat insole on variables. No difference was found on jump shot scored percentage, jump height, peak ground reaction force, time to peak force and rate of force development. Wearing arch supporting insole did not influence the jump shot scored percentage and kinetics during jump shot

Early Detection of Tumor Response by FLT/MicroPET Imaging in a C26 Murine Colon Carcinoma Solid Tumor Animal Model

Fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) imaging demonstrated the change of glucose consumption of tumor cells, but problems with specificity and difficulties in early detection of tumor response to chemotherapy have led to the development of new PET tracers. Fluorine-18-fluorothymidine (18F-FLT) images cellular proliferation by entering the salvage pathway of DNA synthesis. In this study, we evaluate the early response of colon carcinoma to the chemotherapeutic drug, lipo-Dox, in C26 murine colorectal carcinoma-bearing mice by 18F-FDG and 18F-FLT. The male BALB/c mice were bilaterally inoculated with 1 × 105 and 1 × 106 C26 tumor cells per flank. Mice were intravenously treated with 10 mg/kg lipo-Dox at day 8 after 18F-FDG and 18F-FLT imaging. The biodistribution of 18F-FDG and 18F-FLT were followed by the microPET imaging at day 9. For the quantitative measurement of microPET imaging at day 9, 18F-FLT was superior to 18F-FDG for early detection of tumor response to Lipo-DOX at various tumor sizes (P < 0.05). The data of biodistribution showed similar results with those from the quantification of SUV (standard uptake value) by microPET imaging. The study indicates that 18F-FLT/microPET is a useful imaging modality for early detection of chemotherapy in the colorectal mouse model

EFFECT OF SHORT MEDIALSIDE STUDS OM FOOT BIOMECHANICS IN COLLEGIATE SOCCER PLAYERS

The purpose of this study was to examine the effect of modified stud on ankle and foot kinematics, ground reaction force and forefoot force and pressure during sidestep cut (SC) and change direction (CD) movement 6 male collegiate soccer players wore original and medial-side 2mm cut stud shoes and performed SC and CD on the artificial grass. Non-parametric Wilcoxon signed-rank test was used to compare difference between the original and modified studs. The modified stud of non-dominant leg show less inversion than the original stud in SC and CD. The modified stud of non-dominant leg show more force peak form and pressure and that of nondominant legs show more pressure an the original stud during SC and CD. The short medial-side studs with 2mm length can decrease the force inversion of the nondmiiant leg during SC and CD movement and increase the force production of the lower extremities in recreational soccer players

Long-Term Prediction of Emergency Department Revenue and Visitor Volume Using Autoregressive Integrated Moving Average Model

This study analyzed meteorological, clinical and economic factors in terms of their effects on monthly ED revenue and visitor volume. Monthly data from January 1, 2005 to September 30, 2009 were analyzed. Spearman correlation and cross-correlation analyses were performed to identify the correlation between each independent variable, ED revenue, and visitor volume. Autoregressive integrated moving average (ARIMA) model was used to quantify the relationship between each independent variable, ED revenue, and visitor volume. The accuracies were evaluated by comparing model forecasts to actual values with mean absolute percentage of error. Sensitivity of prediction errors to model training time was also evaluated. The ARIMA models indicated that mean maximum temperature, relative humidity, rainfall, non-trauma, and trauma visits may correlate positively with ED revenue, but mean minimum temperature may correlate negatively with ED revenue. Moreover, mean minimum temperature and stock market index fluctuation may correlate positively with trauma visitor volume. Mean maximum temperature, relative humidity and stock market index fluctuation may correlate positively with non-trauma visitor volume. Mean maximum temperature and relative humidity may correlate positively with pediatric visitor volume, but mean minimum temperature may correlate negatively with pediatric visitor volume. The model also performed well in forecasting revenue and visitor volume

Rhodiola crenulata extract for prevention of acute mountain sickness: a randomized, double-blind, placebo-controlled, crossover trial

BACKGROUND: Rhodiola crenulata (R. crenulata) is widely used to prevent acute mountain sickness in the Himalayan areas and in Tibet, but no scientific studies have previously examined its effectiveness. We conducted a randomized, double-blind, placebo-controlled crossover study to investigate its efficacy in acute mountain sickness prevention. METHODS: Healthy adult volunteers were randomized to 2 treatment sequences, receiving either 800 mg R. crenulata extract or placebo daily for 7 days before ascent and 2 days during mountaineering, before crossing over to the alternate treatment after a 3-month wash-out period. Participants ascended rapidly from 250 m to 3421 m on two separate occasions: December 2010 and April 2011. The primary outcome measure was the incidence of acute mountain sickness, as defined by a Lake Louise score ≥ 3, with headache and at least one of the symptoms of nausea or vomiting, fatigue, dizziness, or difficulty sleeping. RESULTS: One hundred and two participants completed the trial. There were no demographic differences between individuals taking Rhodiola-placebo and those taking placebo-Rhodiola. No significant differences in the incidence of acute mountain sickness were found between R. crenulata extract and placebo groups (all 60.8%; adjusted odds ratio (AOR) = 1.02, 95% confidence interval (CI) = 0.69–1.52). The incidence of severe acute mountain sickness in Rhodiola extract vs. placebo groups was 35.3% vs. 29.4% (AOR = 1.42, 95% CI = 0.90–2.25). CONCLUSIONS: R. crenulata extract was not effective in reducing the incidence or severity of acute mountain sickness as compared to placebo. TRIAL REGISTRATION: ClinicalTrials.gov NCT01536288

Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio

<p>Abstract</p> <p>Background</p> <p>Hesperetin was reported to selectively inhibit phosphodiesterase 4 (PDE4). While hesperetin-7,3'-<it>O</it>-dimethylether (HDME) is a synthetic liposoluble hesperetin. Therefore, we were interested in investigating its selectivity on PDE4 and binding ability on high-affinity rolipram-binding sites (HARBs) <it>in vitro</it>, and its effects on ovalbumin-induced airway hyperresponsiveness <it>in vivo</it>, and clarifying its potential for treating asthma and chronic obstructive pulmonary disease (COPD).</p> <p>Methods</p> <p>PDE1~5 activities were measured using a two-step procedure. The binding of HDME on high-affinity rolipram-binding sites was determined by replacing 2 nM [³<it>H</it>]-rolipram. AHR was assessed using the FlexiVent system and barometric plethysmography. Inflammatory cells were counted using a hemocytometer. Cytokines were determined using mouse T helper (Th)1/Th2 cytokine CBA kits, and total immunoglobulin (Ig)E or IgG_2alevels were done using ELISA method. Xylazine (10 mg/kg)/ketamine (70 mg/kg)-induced anesthesia was performed.</p> <p>Results</p> <p>HDME revealed selective phosphodiesterase 4 (PDE4) inhibition with a therapeutic (PDE4_H/PDE4_L) ratio of 35.5 <it>in vitro</it>. <it>In vivo</it>, HDME (3~30 μmol/kg, orally (p.o.)) dose-dependently and significantly attenuated the airway resistance (R_L) and increased lung dynamic compliance (C_dyn), and decreased enhanced pause (P_enh) values induced by methacholine in sensitized and challenged mice. It also significantly suppressed the increases in the numbers of total inflammatory cells, macrophages, lymphocytes, neutrophils, and eosinophils, and levels of cytokines, including interleukin (IL)-2, IL-4, IL-5, interferon-γ, and tumor necrosis factor-α in bronchoalveolar lavage fluid (BALF) of these mice. In addition, HDME (3~30 μmol/kg, p.o.) dose-dependently and significantly suppressed total and ovalbumin-specific immunoglobulin (Ig)E levels in the BALF and serum, and enhanced IgG_2alevel in the serum of these mice.</p> <p>Conclusions</p> <p>HDME exerted anti-inflammatory effects, including suppression of AHR, and reduced expressions of inflammatory cells and cytokines in this murine model, which appears to be suitable for studying the effects of drugs on atypical asthma and COPD, and for screening those on typical asthma. However, HDME did not influnce xylazine/ketamine-induced anesthesia. Thus HDME may have the potential for use in treating typical and atypical asthma, and COPD.</p