Association of opioid dose reduction with opioid overdose and opioid use disorder among patients on high-dose long-term opioid therapy in North Carolina

Presentation at the 38th International Conference on Pharmacoepidemiology [ICPE]. Objective: to characterize the association between rapid reduction or abrupt discontinuation of opioid therapy* and incidence of opioid overdose and OUD among patients receiving high-dose long-term opioid therapy (HDLTOT). [* vs maintained or gradual reduction